folh1
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  • Official Full Name
  • folate hydrolase (prostate-specific membrane antigen) 1
  • Background
  • This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
  • Synonyms
  • FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;
Cat.#:FOLH1-2430HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLH1 Protein, MYC/DDK-tagged
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Cat.#:FOLH1-4417HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FOLH1 Protein, GST-tagged
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Cat.#:FOLH1-2415HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FOLH1, His-tagged
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Cat.#:FOLH1-2416HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLH1 protein, His-tagged
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Cat.#:FOLH1-31003THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOLH1
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Cat.#:FOLH1-7844HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOLH1 protein, His-tagged
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Cat.#:Folh1-7845MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Folh1 protein, His & T7-tagged
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Cat.#:Folh1-907MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folh1, His tagged
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Cat.#:FOLH1-2379RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FOLH1 Protein
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Cat.#:FOLH1-2414HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Folate Hydrolase, GST-tagged
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Cat.#:FOLH1-2452MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FOLH1 cell lysate
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Involved Pathway

FOLH1 involved in several pathways and played different roles in them. We selected most pathways FOLH1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOLH1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
GLUL; GLUD1; GLUD1B; AGXT2; GLSA; IL4I1; RIMKLB; GOT2B; ADSSL; PPAT
Metabolic pathways
CBR1L; GPT2; CKMT1; HSD3B7; MINPP1B; SAT2; DNMT3A; DCTPP1; DSE; PTGS1
Vitamin digestion and absorption
CUBN; TCN2; GIF; SLC19A3; BTD; MMACHC; ABCC1; SLC46A1; RBP2; SCARB1

Protein Function

FOLH1 has several biochemical functions, for example, Ac-Asp-Glu binding, dipeptidase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOLH1 itself. We selected most functions FOLH1 had, and list some proteins which have the same functions with FOLH1. You can find most of the proteins on our site.
Function
Related Protein
Function Ac-Asp-Glu binding
Related Protein FOLH1
Function dipeptidase activity
Related Protein CNDP2; CNDP1; SCRN3; DPEP3; FOLH1; PEPD; SCRN1; DPEP2; NAALAD2; SCRN2
Function metal ion binding
Related Protein AGAP1; HPDB; PNLIP; ZSCAN21; ZMIZ2; ZFP12; C6AST3; ZNF80; MORC2A; ERCC2
Function metallocarboxypeptidase activity
Related Protein CPDB; CPA5; CPM; AGBL2; PEPD; CPB1; CPA1; AGBL3; CPA3; CPE
Function peptidase activity
Related Protein PGCP; CTSSB.1; ZRANB1B; F2RL1.1; DESI2; THSD4; IHHA; ADAM1B; KLK1B8; CTSSB.2
Function tetrahydrofolyl-poly(glutamate) polymer binding
Related Protein FOLH1

Interacting Protein

FOLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOLH1.
Dlg4; RPS3; MTAP; MME

FOLH1 Related Articles

Haffner, MC; Laimer, J; et al. High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. MODERN PATHOLOGY 25:1079-1085(2012).
Haffner, MC; Kronberger, IE; et al. Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. HUMAN PATHOLOGY 40:1754-1761(2009).