gdi2
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  • Official Full Name
  • GDP dissociation inhibitor 2
  • Background
  • GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • GDI2; GDP dissociation inhibitor 2; rab GDP dissociation inhibitor beta; rab GDP dissociation; RABGDIB; GDI-2; GDIB_HUMAN; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta; rab GDP-dissociation inhibitor, beta
Cat.#:GDI2-2332HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GDI2 Protein (1-445 aa), His-tagged
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Cat.#:GDI2-4833HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDI2 Protein, GST-tagged
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Cat.#:GDI2-636HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDI2 Protein, MYC/DDK-tagged
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Cat.#:GDI2-13214HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDI2, His-tagged
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Cat.#:GDI2-161HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDI2, His-tagged
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Cat.#:GDI2-28229THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GDI2
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Cat.#:GDI2-2505RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GDI2 Protein
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Cat.#:GDI2-1826RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GDI2 Protein, His-tagged
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Cat.#:GDI2-6562CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GDI2
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Cat.#:GDI2-10054ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GDI2
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Cat.#:GDI2-2972HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDI2, T7-tagged
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Cat.#:GDI2-5964HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GDI2 293 Cell Lysate
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Involved Pathway

GDI2 involved in several pathways and played different roles in them. We selected most pathways GDI2 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rho GTPase cycle
ARHGAP17; ARHGAP29B; ARHGAP17B; TAGAPA; ARHGAP19; RALBP1; ARHGAP26; OBSCN; ARHGAP9; RHOT1
Signal Transduction
RHOT2; SOUL3; PDK3B; OTULINB; MOB1BA; SCT; ADAM12; PRDM4; GPR65; PRICKLE1
Signaling by Rho GTPases
DLC1; ABI1A; ARHGAP6; CHN1; RHOT1A; RHPN2; ARHGAP15; TAGAPA; FMNL1; TAX1BP3

Protein Function

GDI2 has several biochemical functions, for example, GTPase activator activity, Rab GDP-dissociation inhibitor activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI2 itself. We selected most functions GDI2 had, and list some proteins which have the same functions with GDI2. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein RAP1GAP2B; HTR2B; TBC1D10C; GAPVD1; ARHGAP4; TBC1D2B; TBC1D22B; OCRL; GRTP1; ARHGAP35
Function Rab GDP-dissociation inhibitor activity
Related Protein GDI2; GDI1
Function oxidoreductase activity
Related Protein GPD1C; GLUD1B; RYROXD1; HSD17B12B; CYP8B3; FAM84B; NDOR1; AKR1C6; SCCPDHA; CYP8B1
Function poly(A) RNA binding
Related Protein ASCC3; MRPS26; GSPT2; HIST1H1C; NPM3; SRP68; DZIP3; YTHDF3; RPF1; NOP58
Function protein binding
Related Protein IARS; FBXO2; NTRK1; OTUB1; CDC42EP1; TBC1D24; SPANXC; CCNB3; BIRC7; HIST1H4I
Function small GTPase binding
Related Protein ABCA1; FLNA; PEX5; RCC2; GDI2; FGD3; PEX5L; FGD4; ERRFI1; FGD2

Interacting Protein

GDI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI2.
Rab10; Rab5c; RAB4A; SGK1; EIF1B; GH1; Cdk1; VHL; EIF6; ARF6; PAK2; TNFRSF14; RAB24; ACTR6; ATG5; PRKAB1

GDI2 Related Articles

Guo, T; Zhang, LQ; et al. Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. SCIENTIFIC REPORTS 5:-(2015).
Hegglin, A; Mikkat, S; et al. Proteomic Study Points Towards Rho-GDI2-connected Signalling During Skin Graft Revascularization. TISSUE ENGINEERING PART A 20:S125-S125(2014).