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GDI2

  • Official Full Name

    GDP dissociation inhibitor 2

  • Overview

    GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms

    GDI2; GDP dissociation inhibitor 2; rab GDP dissociation inhibitor beta; rab GDP dissociation; RABGDIB; GDI-2; GDIB_HUMAN; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta; rab GDP-dissociation inhibitor, beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDI2-28229TH Recombinant Human GDI2 Wheat Germ N/A 100 amino acids
Human GDI2-636H Recombinant Human GDI2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GDI2-13214H Recombinant Human GDI2, His-tagged E.coli His 1-232a.a.
Human GDI2-161H Recombinant Human GDI2, His-tagged E.coli His 1-445aa
Human GDI2-2972H Recombinant Human GDI2, T7-tagged E.coli T7
Human GDI2-5964HCL Recombinant Human GDI2 293 Cell Lysate HEK293 N/A
Human GDI2-2603H Recombinant Human GDI2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GDI2-4833H Recombinant Human GDI2 Protein, GST-tagged Wheat Germ GST
Human GDI2-2954H Recombinant Human GDI2 protein, His-SUMO-tagged E.coli His-SUMO 1-445aa
Human GDI2-2332H Recombinant Human GDI2 Protein (1-445 aa), His-tagged Yeast His 1-445 aa
Human GDI2-5151H Recombinant Human GDI2 protein, GST-tagged E.coli GST 1-441aa
Human GDI2-5246HF Recombinant Full Length Human GDI2 Protein, GST-tagged In Vitro Cell Free System GST 445 amino acids
Mouse Gdi2-3183M Recombinant Mouse Gdi2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GDI2-2505R Recombinant Rat GDI2 Protein Mammalian Cell His
Rat GDI2-2161R-B Recombinant Rat GDI2 Protein Pre-coupled Magnetic Beads HEK293
Rat GDI2-2161R Recombinant Rat GDI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GDI2-1826R Recombinant Rhesus monkey GDI2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GDI2-1647R-B Recombinant Rhesus Macaque GDI2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GDI2-1647R Recombinant Rhesus Macaque GDI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GDI2-10054Z Recombinant Zebrafish GDI2 Mammalian Cell His
Chicken GDI2-6562C Recombinant Chicken GDI2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDI2 Related Articles

GDI2 involved in several pathways and played different roles in them. We selected most pathways GDI2 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rho GTPase cycleARHGAP4A;GDI2;RHOU;DEPDC7;ARHGAP29B;FAM13B1;DCLRE1B;RHOF;RALBP1
Signal TransductionPRICKLE1;INTU;OXGR1A.2;CD97;SAGB;ARHGAP29;ARHGAP19;ARAP2;HECW1
Signaling by Rho GTPasesLIN7B;PLEKHG2;FGD4;MYO9B;ARHGAP33;STARD8;STARD13;TAGAPB;RHOT1A

GDI2 has several biochemical functions, for example, GTPase activator activity, Rab GDP-dissociation inhibitor activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI2 itself. We selected most functions GDI2 had, and list some proteins which have the same functions with GDI2. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityTBC1D30;ARHGAP36;AGAP1;MURC;FAM13B;RGS9A;TBC1D1;ARHGAP26;ARHGAP6
Rab GDP-dissociation inhibitor activityGDI2;GDI1
oxidoreductase activityALDH2.1;C10orf33;CYP1A1;CYP4A12A;HADHAA;GPD1C;SRD5A3;DHRS7CA;TECRL
poly(A) RNA bindingPPAN;YTHDF2;HNRNPL;FUS;G3BP1;MRPS7;SUPT5H;HNRNPUL1;HNRNPDL
protein bindingVRK1;TMEM174;STXBP3A;GRB2;GRN;KLK4;GOPC;CXXC11;MICA
small GTPase bindingRNF152;RCC2;TSC2;ERRFI1;FGD4;FGD6;FLNA;FGD1;FGD3

GDI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI2.

Rab10; Rab5c; RAB4A; SGK1; EIF1B; GH1; Cdk1; VHL; EIF6; ARF6; PAK2; TNFRSF14; RAB24; ACTR6; ATG5; PRKAB1

Guo, T; Zhang, LQ; et al. Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. SCIENTIFIC REPORTS 5:-(2015).
Hegglin, A; Mikkat, S; et al. Proteomic Study Points Towards Rho-GDI2-connected Signalling During Skin Graft Revascularization. TISSUE ENGINEERING PART A 20:S125-S125(2014).
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