GGCX
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Official Full Name
gamma-glutamyl carboxylase
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Overview
This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GGCX; gamma-glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; vitamin K dependent gamma carboxylase; VKCFD1; FLJ26629; Gamma glutamyl carboxylase; GC; Peptidyl glutamate 4 carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase; VKCFD 1; VKGC_HUMAN; OTTHUMP00000160676; OTTHUMP00000203090;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Delphinapterus leucas (Beluga whale)
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- C
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | GGCX-29018TH | Recombinant Human GGCX | Wheat Germ | N/A | 97 amino acids |
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| Human | GGCX-13240H | Recombinant Human GGCX, GST-tagged | E.coli | GST | 383-758a.a. | |
| Human | GGCX-5949HCL | Recombinant Human GGCX 293 Cell Lysate | HEK293 | N/A |
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| Human | GGCX-0673H | Recombinant Human GGCX Protein (M1-F758), Flag tagged | Insect Cell | Flag | M1-F758 |
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| Human | GGCX-4870H | Recombinant Human GGCX Protein, GST-tagged | Wheat Germ | GST |
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| Human | GGCX-06H | Recombinant Human GGCX Protein (M1-F758 end, L573F), C-Flag-tagged | Insect Cell | C-Flag | M1-F758 end, L573F |
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| Rat | GGCX-2517R | Recombinant Rat GGCX Protein | Mammalian Cell | His |
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| Rat | GGCX-2173R | Recombinant Rat GGCX Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | GGCX-2173R-B | Recombinant Rat GGCX Protein Pre-coupled Magnetic Beads | HEK293 |
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| Delphinapterus leucas (Beluga whale) | RFL8124DF | Recombinant Full Length Delphinapterus Leucas Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-758) |
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| Homo sapiens (Human) | RFL10648HF | Recombinant Full Length Human Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-758) |
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| Mus musculus (Mouse) | RFL36284MF | Recombinant Full Length Mouse Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-757) |
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| Ovis aries (Sheep) | RFL4633OF | Recombinant Full Length Sheep Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-758) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL745PF | Recombinant Full Length Pongo Abelii Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-758) |
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| Rattus norvegicus (Rat) | RFL25508RF | Recombinant Full Length Rat Vitamin K-Dependent Gamma-Carboxylase(Ggcx) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-758) |
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| Rhesus Macaque | GGCX-1838R | Recombinant Rhesus monkey GGCX Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | GGCX-1659R-B | Recombinant Rhesus Macaque GGCX Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | GGCX-1659R | Recombinant Rhesus Macaque GGCX Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- GGCX Related Articles
GGCX involved in several pathways and played different roles in them. We selected most pathways GGCX participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGCX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquinone and other terpenoid-quinone biosynthesis | GGCX;HPDA;AMOTL1;COQ3;HPD;COQ7;VKORC1;COQ5;HPDB |
GGCX has several biochemical functions, for example, gamma-glutamyl carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGCX itself. We selected most functions GGCX had, and list some proteins which have the same functions with GGCX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gamma-glutamyl carboxylase activity | PDXDC1;GGCX |
GGCX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGCX here. Most of them are supplied by our site. Hope this information will be useful for your research of GGCX.
Mgp; AP1S2; Ncstn; Tubg1; Smn1; FGD1; Anapc2; Cdc16; FAM46A; Mad2l1bp; TERF2IP
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