Recombinant Human GGCX Protein (M1-F758 end, L573F), C-Flag-tagged

• Cat.No.: GGCX-06H
• Product Overview: Recombinant human P371(M1-F758 end) (L573F)-Flag was expressed in insect cells.

Specification

• Description: This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants.
• Source: Insect cell
• Species: Human
• Tag: C-Flag
• Form: Liquid
• Protein Length: M1-F758 end, L573F
• Endotoxin: < 0.01 EU/μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 150 mM NaCl, 20 mM HEPES (pH 7.5), 10 mM DTT, 10 mM CaCl2, 0.005% GDN
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: GGCX gamma-glutamyl carboxylase [ Homo sapiens (human) ]
• Official Symbol: GGCX
• Synonyms: GGCX; gamma-glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; vitamin K dependent gamma carboxylase; VKCFD1; peptidyl-glutamate 4-carboxylase; FLJ26629
• Gene ID: 2677
• mRNA Refseq: NM_000821
• Protein Refseq: NP_000812
• MIM: 137167
• UniProt ID: P38435