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GZMM

Official Full Name

granzyme M (lymphocyte met-ase 1)
Overview

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
Synonyms

GZMM; granzyme M (lymphocyte met-ase 1); granzyme M; LMET1; lymphocyte met ase 1; MET1; Granzyme M (lymphocyte met ase 1); GranzymeM; GZM M; HU Met 1; LMET 1; MET 1; Met 1 serine protease; Met ase; Met1 serine protease; Natural killer cell granular protease; met-ase; HU-Met-1; lymphocyte met-ase 1; Met-1 serine protease;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
His|GST
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GZMM-98H	Active Recombinant Human GZMM protein, His-tagged	E.coli	His	Ile26~Ala257	$298 / 10ug
Human	GZMM-4526H	Recombinant Human GZMM Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GZMM-97H	Recombinant Human GZMM, His-tagged	HEK293	His		Inquiry
Human	GZMM-5666HCL	Recombinant Human GZMM 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GZMM-3350H	Recombinant Human GZMM Protein (Ile26-Ala257), His tagged	E.coli	His	Ile26-Ala257	Inquiry
Human	GZMM-3394HF	Recombinant Full Length Human GZMM Protein, GST-tagged	In Vitro Cell Free System	GST	257 amino acids	Inquiry
Mouse	Gzmm-651M	Recombinant Mouse Gzmm Protein, His/GST-tagged	E.coli	His/GST	Arg31~Arg257	$198 / 5ug $398 / 10ug $1,398 / 50ug
Rat	Gzmm-652R	Recombinant Rat Gzmm Protein, His/GST-tagged	E.coli	His/GST	Ala19~Arg251	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GZMM Related Research Area

GZMM involved in several pathways and played different roles in them. We selected most pathways GZMM participated on our site, such as Alternative complement activation, Complement cascade, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Alternative complement activation	CFD;GZMM;BFB
Complement cascade	CFHL1;MASP2;FCN1;IGKC;FCN3;IGLC2;FCN2;CFHL4;IgG3
Immune System	WASF2;PELI2;TRIM63;TRIM11;AP1G1;CLEC6A;CYLD;AGER;IFIT2
Initial triggering of complement	FCN3;IgG3;BFB;GZMM;CRP;C1rb;FCN1;FCN2;CFD
Innate Immune System	PCBP2;DEFB4B;CLEC6A;TRIM56;WIPF3;BTR12;FCN1;NOD1;MASP2

GZMM has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMM itself. We selected most functions GZMM had, and list some proteins which have the same functions with GZMM. You can find most of the proteins on our site.

Function	Related Protein
protein binding	SYT4;EFNA4;CREBBP;KRTAP2-3;IRAK1BP1;TPM1;ZEB1;FAM124A;LIN7A
serine-type endopeptidase activity	PRSS28;HTRA1A;KEX2;C1RA;KLK1B9;KLK1B16;GZMK;KLK1B1;PLG
serine-type peptidase activity	DPP7;DPP8;PREP;TMPRSS4A;TMPRSS4B;KLK10;KEX2;TPSG1;PLG

GZMM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMM here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMM.

Cytotoxic T Cells (CTLs)