hexa
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  • Official Full Name
  • hexosaminidase A (alpha polypeptide)
  • Background
  • This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
  • Synonyms
  • HEXA; hexosaminidase A (alpha polypeptide); beta-hexosaminidase subunit alpha; GM2 gangliosidosis; Tay Sachs disease; Beta hexosaminidase alpha chain precursor; Beta hexosaminidase subunit alpha; Beta N acetylhexosaminidase; Beta N acetylhexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; HEXA_HUMAN; Hexosaminidase A alpha polypeptide; Hexosaminidase A; Hexosaminidase subunit A; MGC99608; N acetyl beta glucosaminidase; N acetyl beta glucosaminidase subunit alpha; N-acetyl-beta-glucosaminidase subunit alpha; TSD
Cat.#:HEXA-1087HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HEXA Protein, MYC/DDK-tagged
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Cat.#:HEXA-4710HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HEXA Protein, GST-tagged
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Cat.#:HEXA-178HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEXA Protein, His-tagged
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Cat.#:HEXA-2523HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HEXA, His tagged
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Cat.#:HEXA-26087THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HEXA
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Cat.#:HEXA-7241HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEXA, His-tagged
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Cat.#:HEXA-93HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HEXA, His-tagged
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Cat.#:Hexa-179MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hexa Protein, His-tagged
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Cat.#:HEXA-7593MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HEXA Protein
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Cat.#:HEXA-2833RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HEXA Protein
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Cat.#:HEXA-2069RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HEXA Protein, His-tagged
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Cat.#:HEXA-2247CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HEXA
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Cat.#:HEXA-6481ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HEXA
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Cat.#:HEXA-548HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HEXA cell lysate
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Involved Pathway

HEXA involved in several pathways and played different roles in them. We selected most pathways HEXA participated on our site, such as Other glycan degradation, Amino sugar and nucleotide sugar metabolism, Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEXA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Other glycan degradation
NEU2; GBA; FUCA1.1; NEU3; NEU3.2; NEU3.5; NEU3.1; MAN2C1; HEXB; NEU4
Amino sugar and nucleotide sugar metabolism
CYB5R2; HEXB; GMPPAA; GPIB; GALK1; GPIA; UAP1L1; CMAH; HEXA; FUK
Glycosaminoglycan degradation
HPSE; IDUA; HEXA; GUSB; HYAL2; SPAM1; IDS; HPSE2; HYAL3; GNS
Glycosphingolipid biosynthesis - globo series
ST3GAL1; HEXB; GBGT1; FUT1; FUT9A; FUT9; ST3GAL2; NAGA; A4GALT; ST8SIA1
Glycosphingolipid biosynthesis - ganglio series
ST6GALNAC4; GLB1; ST6GALNAC6; ST3GAL1; HEXB; SLC33A1; ST8SIA1; B3GALT4; ST3GAL2; HEXA
Metabolic pathways
GLCEA; DHODH; MTMR4; IDH1; SDS; SHMT2; COX6C; TYMP; CYP4F2; FLAD1
Lysosome
IGF2R; CTPS1B; TPP1; NAGA; CTSF; ATP6V0A2; CTSM; SLC11A2; ATP6V1H; CTSK

Protein Function

HEXA has several biochemical functions, for example, acetylglucosaminyltransferase activity, beta-N-acetylhexosaminidase activity, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEXA itself. We selected most functions HEXA had, and list some proteins which have the same functions with HEXA. You can find most of the proteins on our site.
Function
Related Protein
Function acetylglucosaminyltransferase activity
Related Protein XYLT1; EXT1; OGT; B3GNT9-PS; DPY19L1; MGAT1A; 4931440L10Rik; POMGNT2; GCNT4A; C3orf39
Function beta-N-acetylhexosaminidase activity
Related Protein HEXB; Chil3; HEXDC; HEXA
Function protein heterodimerization activity
Related Protein TP53; BMP2; SOX9; CEBPA; SDCBP2; TBX18; VAPA; SLC51B; BCL2L1; ITGB1A

Interacting Protein

HEXA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEXA here. Most of them are supplied by our site. Hope this information will be useful for your research of HEXA.
ABL1; FYN; CRK; USP22; SYNCRIP; cona_canen; Tuba3a; H2AFX; BAG6; Ypel5; HNRNPD; SGTB; CEP170P1; FAN1

HEXA Related Articles

Puhan, D; Bijwe, J; et al. Investigations on Performance Properties of Nano-Micro Composites Based on Polyetherketone, Short Carbon Fibers and Hexa-Boron Nitride. SCIENCE OF ADVANCED MATERIALS 7:1002-1011(2015).
Srinivas, K; Babu, CN; et al. Thermal, optical and structural properties of disulfide and diselenide salts with weakly associated anions. JOURNAL OF MOLECULAR STRUCTURE 1086:201-206(2015).