HLA-E
-
Official Full Name
major histocompatibility complex, class I, E
-
Overview
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. -
Synonyms
HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- SUMO
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | HLA-E-1746H | Recombinant Human HLA-E protein, His-tagged | E.coli | His | Gly22~Leu358 | |
Human | HLA-E-4847H | Recombinant Human HLA-E Protein, GST-tagged | Wheat Germ | GST | ||
Human | HLA-E-800HCL | Recombinant Human HLA-E cell lysate | N/A | |||
Human | HLA-E-039H | Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. | |
Human | HLA-E-038H | Recombinant Human HLA-E protein, His-Avi-tagged | HEK293 | His-Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. | |
Human | HLA-E-2276H | Recombinant Human HLA-E protein, His&Myc-tagged | Insect Cell | His&Myc | 22-305aa | |
Human | HLA-E-1076H | Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | HLA-E-3602HF | Recombinant Full Length Human HLA-E Protein, GST-tagged | In Vitro Cell Free System | GST | 358 amino acids | |
Human | HLA-E-1749H | Recombinant Human HLA-E Protein, MYC/DDK-tagged | HEK293T | Myc/DDK | ||
Human | HLA-E-3399H | Recombinant Human HLA-E protein, His-tagged | E.coli | His | 23-303 aa | |
Human | HLA-E-1076H-B | Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | HLA-E-268HFL | Recombinant Full Length Human HLA-E Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | HLA-E-3872H | Recombinant Human HLA-E protein, His-SUMO-tagged | E.coli | His-SUMO | 22-305aa | |
Human | HLA-E-040HP | Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | His-Avi | Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-E Related Articles
- HLA-E Related Research Area
HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Endocytosis | ZFYVE16;ARPC1A;ARPC5A;KIF5A;CHMP6B;PLD1A;SH3GL3;SNX12;RAB7A |
Phagosome | ATP6V1AA;ACTB;TUBB5;BMA2;Itgam&Itgb2;SEC22B;TFRC;MARCO;SEC22BB |
Cell adhesion molecules (CAMs) | ICAM1;CD58;ITGA6;CNTN1;CNTNAP2A;CD34;CLDN5A;CLDN3;CLDN15LB |
Antigen processing and presentation | PSME1;HLA-A;HLA-F;KLRD1;TNF;NFYB;HLA-DRB5;NFYA;HLA-DQA2 |
Natural killer cell mediated cytotoxicity | KIR2DS5;CD48;PRF1;KIR2DS2;PIK3CG;BRAF;KIR2DS3;MICB;FYN |
Type I diabetes mellitus | INS2;FAS;HLA-DPA1;HLA-F;Fasl;HLA-DQA1;HLA-DQA2;H2-AB1;IL1B |
HTLV-I infection | ICAM1;NFYB;TRP53INP1;TGFB1;PIK3R1;EGR1;HLA-DRB5;AKT1;HLA-B |
Herpes simplex infection | HLA-F;BF1;SRSF1A;SRSF7A;SRSF5B;OAS1A;EEF1DB;NXF1;HLA-DOB |
Epstein-Barr virus infection | TRAF3;MDM2;PIK3CD;PSMD13;PLCG2;HLA-DQA1;MAPK9;PRKACA;HSPB2 |
Viral carcinogenesis | TP53;HIST1H4L;PRKACG;HIST1H4N;YWHAE;RBPJL;HIST3H2BB-PS;HRAS;SRC |
Autoi | IL5;Ifna15;IFNA21;HLA-DRB4;CD80;HLA-DRB5;HLA-DQA2;HLA-DQA1;CD40LG |
ne thyroid disease | TG;IFNA16;IFNA21;IFNA17;IFNA8;HLA-F;HLA-C;PRF1;IFNA13 |
Allograft rejection | HLA-DPB1;HLA-DRB4;HLA-DRA;IL10;HLA-B;FASLG;CD40;HLA-DRB3;IL4 |
Graft-versus-host disease | HLA-DRB3;CD80;HLA-F;FAS;IL1A;IL6;HLA-DQB1;HLA-DRB1;KIR3DL2 |
Viral myocarditis | HLA-DQB1;CD80;CASP8;HLA-DRA;RAC1;ITGB2;CD86;ABL2;FYN |
HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
MHC class I protein binding | LILRB1;BCAP31;ATP5A1;TAPBP;ATP5B;LILRB2;DERL1;VCP;CD8A |
beta-2-microglobulin binding | CD1D;HLA-E;CD1E;HFE;CD1D2;FCGRT;CD1C;CD1A;CD1B |
natural killer cell lectin-like receptor binding | RAET1G;ULBP3;ULBP1;CLEC2H;RAET1E;RAET1L;Mill2;RAET1D;MICB |
peptide antigen binding | MHC1ZKA;MHC1UDA;HLA-DPA1;H2-AA;MHC1UEA;HLA-DRB4;HLA-DRA;MHC1UKA;HLA-A |
receptor binding | GFRA3;CTNND1;RAB8B;EDN3;ACOT8;PLAUR;HILPDA;DHRS4;AMACR |
HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All HLA-E Products
Required fields are marked with *
My Review for All HLA-E Products
Required fields are marked with *