Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

HLA-E

  • Official Full Name

    major histocompatibility complex, class I, E

  • Overview

    HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
  • Synonyms

    HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • SUMO
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-E-1746H Recombinant Human HLA-E protein, His-tagged E.coli His Gly22~Leu358
Human HLA-E-4847H Recombinant Human HLA-E Protein, GST-tagged Wheat Germ GST
Human HLA-E-800HCL Recombinant Human HLA-E cell lysate N/A
Human HLA-E-039H Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
Human HLA-E-038H Recombinant Human HLA-E protein, His-Avi-tagged HEK293 His-Avi It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
Human HLA-E-2276H Recombinant Human HLA-E protein, His&Myc-tagged Insect Cell His&Myc 22-305aa
Human HLA-E-1076H Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HLA-E-3602HF Recombinant Full Length Human HLA-E Protein, GST-tagged In Vitro Cell Free System GST 358 amino acids
Human HLA-E-1749H Recombinant Human HLA-E Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human HLA-E-3399H Recombinant Human HLA-E protein, His-tagged E.coli His 23-303 aa
Human HLA-E-1076H-B Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads HEK293
Human HLA-E-268HFL Recombinant Full Length Human HLA-E Protein, C-Flag-tagged Mammalian cells Flag
Human HLA-E-3872H Recombinant Human HLA-E protein, His-SUMO-tagged E.coli His-SUMO 22-305aa
Human HLA-E-040HP Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 His-Avi Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-E Related Articles
  • HLA-E Related Research Area

HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisZFYVE16;ARPC1A;ARPC5A;KIF5A;CHMP6B;PLD1A;SH3GL3;SNX12;RAB7A
PhagosomeATP6V1AA;ACTB;TUBB5;BMA2;Itgam&Itgb2;SEC22B;TFRC;MARCO;SEC22BB
Cell adhesion molecules (CAMs)ICAM1;CD58;ITGA6;CNTN1;CNTNAP2A;CD34;CLDN5A;CLDN3;CLDN15LB
Antigen processing and presentationPSME1;HLA-A;HLA-F;KLRD1;TNF;NFYB;HLA-DRB5;NFYA;HLA-DQA2
Natural killer cell mediated cytotoxicityKIR2DS5;CD48;PRF1;KIR2DS2;PIK3CG;BRAF;KIR2DS3;MICB;FYN
Type I diabetes mellitusINS2;FAS;HLA-DPA1;HLA-F;Fasl;HLA-DQA1;HLA-DQA2;H2-AB1;IL1B
HTLV-I infectionICAM1;NFYB;TRP53INP1;TGFB1;PIK3R1;EGR1;HLA-DRB5;AKT1;HLA-B
Herpes simplex infectionHLA-F;BF1;SRSF1A;SRSF7A;SRSF5B;OAS1A;EEF1DB;NXF1;HLA-DOB
Epstein-Barr virus infectionTRAF3;MDM2;PIK3CD;PSMD13;PLCG2;HLA-DQA1;MAPK9;PRKACA;HSPB2
Viral carcinogenesisTP53;HIST1H4L;PRKACG;HIST1H4N;YWHAE;RBPJL;HIST3H2BB-PS;HRAS;SRC
AutoiIL5;Ifna15;IFNA21;HLA-DRB4;CD80;HLA-DRB5;HLA-DQA2;HLA-DQA1;CD40LG
ne thyroid diseaseTG;IFNA16;IFNA21;IFNA17;IFNA8;HLA-F;HLA-C;PRF1;IFNA13
Allograft rejectionHLA-DPB1;HLA-DRB4;HLA-DRA;IL10;HLA-B;FASLG;CD40;HLA-DRB3;IL4
Graft-versus-host diseaseHLA-DRB3;CD80;HLA-F;FAS;IL1A;IL6;HLA-DQB1;HLA-DRB1;KIR3DL2
Viral myocarditisHLA-DQB1;CD80;CASP8;HLA-DRA;RAC1;ITGB2;CD86;ABL2;FYN

HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.

Function Related Protein
MHC class I protein bindingLILRB1;BCAP31;ATP5A1;TAPBP;ATP5B;LILRB2;DERL1;VCP;CD8A
beta-2-microglobulin bindingCD1D;HLA-E;CD1E;HFE;CD1D2;FCGRT;CD1C;CD1A;CD1B
natural killer cell lectin-like receptor bindingRAET1G;ULBP3;ULBP1;CLEC2H;RAET1E;RAET1L;Mill2;RAET1D;MICB
peptide antigen bindingMHC1ZKA;MHC1UDA;HLA-DPA1;H2-AA;MHC1UEA;HLA-DRB4;HLA-DRA;MHC1UKA;HLA-A
receptor bindingGFRA3;CTNND1;RAB8B;EDN3;ACOT8;PLAUR;HILPDA;DHRS4;AMACR

HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.

YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A

Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HLA-E Products

Required fields are marked with *

My Review for All HLA-E Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends