hla-e
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  • Official Full Name
  • major histocompatibility complex, class I, E
  • Background
  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
  • Synonyms
  • HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218
Cat.#:HLA-E-4847HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HLA-E Protein, GST-tagged
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Cat.#:HLA-E-1746HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-E protein, His-tagged
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Cat.#:HLA-E-800HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HLA-E cell lysate
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Involved Pathway

HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
ZFYVE9; D6WSU116E; DNM3; KDR; RNF41; CHMP2A; RLN1; TSG101A; SMURF2; FGFR2
Phagosome
ACTG1; HBL4; HLA-DOA; MBL1; TUBA1C; EEA1; CD209; THBS4B; MHC1UXA2; TFRC
Cell adhesion molecules (CAMs)
CLDN11B; SDC2; ITGA8; JAM2; NRXN3; CNTNAP2; PTPRFB; ITGB2L; HLA-DQB1; CLDN17
Antigen processing and presentation
KIR3DL2; HLA-DQA2; CD74; TAPBP; KIR2DL4; HSPA8; Ctsl; NFYA; CALR; HLA-DPA1
Natural killer cell mediated cytotoxicity
SHC1; TNFRSF10D; ITGB2L; LAT; TNFRSF10A; Raet1c; ARAF; HCST; HLA-G; IFNA5
Type I diabetes mellitus
INS; PTPRN2; CD28; IL12A; H2-AA; Fasl; HLA-DQA1; HLA-DRB5; CD86; HLA-DPA1
HTLV-I infection
HLA-A; NFATC2; IKBKB; DVL3; KAT2B; RRAS2; HLA-DPB1; RAN; CDC26; TGFBR1
Herpes simplex infection
SRSF9; IRF3; SOCS3; CUL1; Ifna11; TLR3; UBE2R2; IFNB; EIF2AK2; SRPK1B
Epstein-Barr virus infection
MAPK10; PRKACG; YWHAE; GTF2E2; MAP2K3; POLR2D; NFKB2; STAT3; TBPL2; HLA-B
Viral carcinogenesis
HIST1H4E; HIST1H4D; BAD; C3; GTF2H3; MDM2; MAD1L1; HIST1H2BI; GTF2H4; HDAC1
Autoi
HLA-DMA; H2-Q10; HLA-DPB1; HLA-G; IL5; Fasl; IFNA17; IFNA8; IFNA12; IFNA10
ne thyroid disease
HLA-DRA; HLA-B; H2-AB1; TPO; HLA-DPB1; CD40LG; HLA-DOB; HLA-DOA; IFNA14; Ifna11
Allograft rejection
MICA; HLA-DRA; HLA-E; IL5; IL12A; IL12B; HLA-DPA1; H2-AB1; FASLG; CD40LG
Graft-versus-host disease
HLA-DRB4; IL1A; HLA-F; Il2; HLA-A; KIR3DL2; TNF; HLA-DMB; KLRD1; IFNG
Viral myocarditis
CAV1; ICAM1; ITGB2; SGCB; CXADR; CD28; HLA-C; CCND1; CD40LG; CD86

Protein Function

HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class I protein binding
Related Protein CD244; CD8B; HLA-E; CD8A; ATP5B; DERL1; TUBB4B; TAP1; VCP; BCAP31
Function beta-2-microglobulin binding
Related Protein CD1D2; HLA-A; CD1E; HFE; CD1d1; CD1A; CD1D; CD1C; HLA-E; H2-Q10
Function natural killer cell lectin-like receptor binding
Related Protein RAET1E; MICA; H60a; ULBP1; MICB; CLEC2H; HLA-E; ULBP2; Raet1a; RAET1D
Function peptide antigen binding
Related Protein H2-AA; MHC1UHA; TAPBP; HLA-DRB1; MHC1UJA; MHC1ZFA; MHC1UFA; HLA-DPA1; HLA-DRA; HLA-DRB3
Function receptor binding
Related Protein HFE2; CXCL10; PPP2R4; PSPN; SSTR3; RSPO1; ANGPTL2; CAT; ADM; BLK

Interacting Protein

HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A

HLA-E Related Articles

Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).