Recombinant Human HLA-E Protein, GST-tagged

• Cat.No.: HLA-E-4847H
• Product Overview: Human HLA-E full-length ORF (1 a.a. - 358 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 66.6 kDa
• AA Sequence: MVDGTLLLLLSEALALTQTWAGSHS LKYFHTSVSRPGRGEPRFISVGYVD DTQFVRFDNDAASPRMVPRAPWMEQ EGSEYWDRETRSARDTAQIFRVNLR TLRGYYNQSEAGSHTLQWMHGCELG PDRRFLRGYEQFAYDGKDYLTLNED LRSWTAVDTAAQISEQKSNDASEAE HQRAYLEDTCVEWLHKYLEKGKETL LHLEPPKTHVTHHPISDHEATLRCW ALGFYPAEITLTWQQDGEGHTQDTE LVETRPAGDGTFQKWAAVVVPSGEE QRYTCHVQHEGLPEPVTLRWKQASQ PTIPIVGIIAGLVLLGSVVSGAVVA AVIWRKKSSGGKGGSYSKAEWSDSA QGSESHSL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HLA-E major histocompatibility complex, class I, E [ Homo sapiens ]
• Official Symbol: HLA-E
• Synonyms: HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218
• Gene ID: 3133
• mRNA Refseq: NM_005516
• Protein Refseq: NP_005507
• MIM: 143010
• UniProt ID: P13747