il-8
Share
  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR3.1; TNFSF12; TNFRSF21; PLEKHO2; BMPR1A; IFNA3; IL24; CCL26; VEGFAB; CCR5
Chemokine signaling pathway
CCL21B; GNG5; CXCL10; BCAR1; CCR1; PREX1; RELA; CRK; RAF1; GNG7
NF-kappa B signaling pathway
LCK; GM10591; CCL19; TRAF1; NFKB2; BCL2L1; BCL2A1; ZAP70; LAT; SYK
Phospholipase D signaling pathway
AGTR1B; AGPAT5; MAPK1; LPAR2; PPAP2B; KIT; CXCR1; PTPN11; RALB; PIK3R1
Toll-like receptor signaling pathway
MAPK11; TBK1; MAPK10; AKT2L; CD86; IKBKB; MAPK12A; CASP8; NFKBIAB; LY96
NOD-like receptor signaling pathway
CASP5; NFKBIAB; BIRC3; PSTPIP1B; MAPK9; MAPK12; NAIP7; IL18; TNF; MAPK1
RIG-I-like receptor signaling pathway
IFNPHI1; IFNA8; IFNW1; TRAF6; IFNA21; AZI2; IFNE; ISG15; TRIM25; IFNB1
Non-alcoholic fatty liver disease (NAFLD)
IKBKB; SREBF1; INS1; GSK3B; NDUFC2-KCTD14; GSK3A; SDHA; NDUFS6; PRKAG1; PIK3CD
Epithelial cell signaling in Helicobacter pylori infection
MAPK8; ATP6V0C; ATP6V1G1; ATP6V0E1; ATP6V1E1; NOD1; IKBKG; MET; TJP1; ATP6V1F
Shigellosis
PFN1; HCLS1; RAC1; MAPK10; ELMO1; IKBKG; MAD2L2; MAPK3; ATG5; ROCK1
Salmonella infection
CCL4L2; NOS2B; CDC42L; RAB7; IFNGR2; TJP1; IL8L1; CCL4; RAC1B; IL1B
Pertussis
MAPK3; ITGB1; IRF3; CALML5; CALM3; GNAI1; MAPK8; ITGA5; IRF8; IL12B
Legionellosis
IL1B; VCP; IL-8; HSPA1L; RAB1A; RELA; TLR4; RAB1B; CASP8; HSPA2
Chagas disease (American trypanosomiasis)
TRAF6; MAPK3; CCL3; MAPK11; CXCL8; MAPK13; SMAD2; CD3E; TGFBR1; PIK3R5
Malaria
MYD88; HGF; GYPA; HBB; IL18; THBS4; SELE; CSF3; ITGB2L; GYPC
Amoebiasis
RAB5B; TGFB1; PRKCB; PIK3R1; TGFB2; COL4A6; PLCB1; MUC2; IL10; IL12A
Hepatitis C
IFNA10; PPP2R2C; TYK2; KRAS; NFKB1; IFNA5; NR1H3; CLDN14; PIK3R3; IFNA21
Hepatitis B
ELK1; PTEN; PIK3CA; OSTN; IFNA10; TLR2; MAVS; IRF7; CREB3L2; CCNA1
Influenza A
FURIN; PIK3R3; DDX39B; KPNA2; PLG; EIF2AK1; PRKCA; HLA-DMB; TNFRSF10C; PRSS3
Pathways in cancer
GNAI2; SPI1; PRKCA; PIK3R1; Casp3; PLCB3; RET; FGF14; FZD8; GNGT2
Transcriptional misregulation in cancer
MLF1; HMGA2; LYL1; IL2RB; LRP2BP; ERG; TSPAN7; PAX5; JMJD1C; PROM1
Bladder cancer
CDK4; RPS6KA5; RB1; MYC; TP53; RASSF1; MAP2K2; EGF; CXCL8; UPK3A
Rheumatoid arthritis
FLT1; TLR2; GM-CSF; TNFRSF11A; ATP6V1D; IL-8; VEGFA; CCL5; HLA-DQA1; FOS

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CCL24; CCL14; CCL34B.1; CXCL16; CCL19; CCL34B.9; CXCL10; CCL3L3; CCL19A.1; CXCL11.8
Function interleukin-8 receptor binding
Related Protein IL-8; MADD; YARS
Function protein binding
Related Protein BARD1; STX1A; LRRIQ3; SOX7; FBN2; FUCA2; FZD2; BCS1L; ZRANB2; GSPT2

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3