il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL28RA; MET; ACVR1B; FAS; GM10591; IL20RA; TNFRSF19; Ccl21a; CCL16; OSMR
Chemokine signaling pathway
STAT5B; GM1987; XCR1; GNGT1; Adcy4; CCR3; CCR1; CXCL6; PTK2; CXCL2
NF-kappa B signaling pathway
GM13304; CCL4; BCL2L1; PIDD1; NFKBIA; BTK; CARD11; BCL10; CXCL2; CD40
Phospholipase D signaling pathway
PDGFD; PDGFRA; PLCG1; PDGFA; PTGFR; INS; FCER1A; GRB2; RALB; RAF1
Toll-like receptor signaling pathway
TLR5; RAC1B; NFKBIA; IKBKB; IFNA5; TLR2-2; MAP2K4A; IFNA8; CCL3L3; MAPK8B
NOD-like receptor signaling pathway
PSTPIP1; CXCL1; PYDC1; SGUT1; TAB2; NLRP1; MAPK12A; MAPK11; MAPK13; TNF
RIG-I-like receptor signaling pathway
IFNA17; IFNA6; FADD; IFNA21; RIPK1; IL12A; IL12BA; TRAF2; IFNK; DAK
Non-alcoholic fatty liver disease (NAFLD)
UQCRFS1; PRKAB2; MAPK8; GSK3A; RELA; Casp3; IL-8; LEP; UQCR11; EIF2AK3
Epithelial cell signaling in Helicobacter pylori infection
SRC; IKBKB; PAK1; NOD1; JAM3; ATP6V0D2; ADAM17; CXCR1; IL-8; MAPK11
Shigellosis
UBE2D2; WASF1; MAPK10; ITGB1; U2AF1L4; ELMO2; PFN1; CTTN; FBXW11; NFKBIA
Salmonella infection
IL8L1; NLRC4; MAPK13; RAB7A; IFNGR2; FOS; NOS2; PLEKHM2; PYCARD; MAPK10
Pertussis
MAPK9; CALML3; ITGA5; FOS; Casp3; ITGB1; IL-8; MYD88; CD14; C1S
Legionellosis
EEF1G; HSF1; IL12B; HSPA2; ITGAM; HSPA8; SAR1B; EEF1A2; VCP; BCL2L13
Chagas disease (American trypanosomiasis)
PPP2R2D; MAPK10; MAPK1; PLCB3; NOS2; PPP2R2A; IKBKB; TGFB2; GNA15; FOS
Malaria
TLR4; LRP1; TGFB3; IL18; MET; HBB-B2; TLR9; COMP; HBB; VCAM1
Amoebiasis
PRKCG; GNA11; COL4A1; IL1R2; ACTN2; PLCB4; CXCL8; LAMB3; IL6; PIK3CD
Hepatitis C
EIF2AK3; MAPK10; IFNA12; RNASEL; AKT1; EIF2AK1; BAD; TNF; IL-8; MAPK3
Hepatitis B
EGR2; MAPK3; IFNA13; BAX; STAT4; KRAS; NFATC4; Ifna11; MAP2K1; SMAD3
Influenza A
TMPRSS4; NFKBIB; EIF2AK4; MAP2K6; OAS1B; EIF2AK3; NUP98; MAPK11; HLA-DQA2; HLA-DPB1
Pathways in cancer
FGF2; RAF1; BIRC8; STK36; FGF3; TRAF3; NKX3; FGF10; XIAP; PML
Transcriptional misregulation in cancer
PPARG; FCGR1A; SFPI1; SPINT1; Pdgfa&Pdgfb; WNT16; GOLPH3L; KDM6A; ETV1; IL6
Bladder cancer
MAPK3; THBS1; FGFR3; DAPK3; MYC; DAPK1; RPS6KA5; EGF; HBEGF; RAF1
Rheumatoid arthritis
ATP6V0A2; CCL2; CXCL1; IL23; TGFB1; TNFSF13; ATP6V0D2; CCL3L3; TNFSF13B; ATP6V0E1

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CCL21B; CCL27; CXCL3; CXCL11; CCL22; CCL34A.3; CCL25B; PF4; CXCL12; CXCL5
Function interleukin-8 receptor binding
Related Protein MADD; IL-8; YARS
Function protein binding
Related Protein PCBD2; TP73; HPRT1; INS; GUCY1B3; DYRK4; ARID3A; FBXL5; PCNP; FBXO45

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3