il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL27B; IL23R; KITLG; GM13304; IL29; CXCL6; IL10RA; Il6ra; CCR8; IL11
Chemokine signaling pathway
CXCL14; CCL6; CCL11; CXCL13; CCL4L2; CCR5; CXCR4; GNAI2; STAT3; SHC1
NF-kappa B signaling pathway
TRAF2; BCL2; PRKCQ; CCL4; IRAK4; BIRC2; TRAF5; CARD11; PIAS4; NFKB2
Phospholipase D signaling pathway
GRM6; MAPK3; PIP5K1B; AVPR2; AGTR1B; FCER1A; AGPAT5; PDGFB; PDGFA; PPAP2A
Toll-like receptor signaling pathway
TNF; MAPK1; FOS; MAPK12A; IL-8; TLR1; IL6; MAPK12B; TRAF6; RIPK1
NOD-like receptor signaling pathway
MAPK14B; NAIP7; TAB2; CXCL2; CCL2; HSP90AA1; PSTPIP1A; MAPK8B; CARD8; IL8L2
RIG-I-like receptor signaling pathway
SIKE1; MAPK12; IL12BA; MAPK13; MAPK14B; ATG12; NT5C3; IL12B; TRADD; IL8L1
Non-alcoholic fatty liver disease (NAFLD)
NDUFB5; PKLR; SDHA; PIK3CA; MAPK9; PRKAA1; PIK3CB; BAX; SDHB; CEBPA
Epithelial cell signaling in Helicobacter pylori infection
IKBKB; ATP6V1D; CDC42; PTPN11; MAPK9; ATP6V0D2; MAPK8; ATP6V0D1; RELA; PLCG1
Shigellosis
FBXW11; RELA; ROCK2; WASL; ELMO1; IKBKB; PFN2; IL-8; MAPK10; RAC1
Salmonella infection
MAPK8B; IFNG; MAPK13; PKN1; PLEKHM2; ARPC5LA; NLRC4; FLNB; NFKB1; CCL3L1
Pertussis
MAPK12; IRF1; TLR4; MAPK13; CD14; NLRP3; CXCL5; IL1B; ITGB2L; IL6
Legionellosis
ITGB2L; CR1; RAB1B; Casp3; NAIP1; HBS1L; CASP9; CYCS; NAIP7; EEF1A1
Chagas disease (American trypanosomiasis)
PIK3CG; IL6; PPP2R2B; GNAO1; CD3D; IKBKG; MAPK11; FAS; CCL3; TLR2
Malaria
MYD88; THBS2; TGFB1; ITGB2; TGFB2; ITGAL; ICAM1; GYPC; SDC1; IL18
Amoebiasis
PIK3R5; LAMC1; PLCB1; ACTN2; PRKACA; SERPINB3C; LAMA5; ITGAM; LAMB2; CSF2
Hepatitis C
IFNA7; TYK2; CLDN9; OAS1A; PPP2R1A; TRP53; PIK3R5; PIK3CD; ARAF; RNASEL
Hepatitis B
CREB3L1; PTK2B; AKT2; MAPK1; TGFB3; MAPK8; IRF3; FOS; PRKCB; IFN-a
Influenza A
IFNAR2; EIF2AK4; HLA-DQA2; TLR3; PIK3R2; DNAJB1; IL18; HLA-DRB5; IFNG; HLA-DQB1
Pathways in cancer
FGFR2; FGF7; EGLN3; LAMC2; BRAF; RARA; CXCL12; PML; ERBB2; RASSF5
Transcriptional misregulation in cancer
MDM2; MMP3; DEFA3; ZEB1; HIST2H3A; PLAU; PROM1; HIST1H3I; IGF1; WNT16
Bladder cancer
CDH1; DAPK2; ERBB2; KRAS; MAP2K1; E2F2; CDKN2A; UPK3A; E2F3; MMP1A
Rheumatoid arthritis
HLA-DRB4; FLT1; Ccl12; HLA-DRB3; LTB; ATP6V0A4; ATP6V1G1; ATP6V0D1; ITGB2L; H2-AB1

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CCL18; CCL34B.4; IL8L2; CCL3L3; CCL34B.1; CXCL2; CXCL11.8; CXCL1; CXCL14; CCL39.1
Function interleukin-8 receptor binding
Related Protein MADD; YARS; IL-8
Function protein binding
Related Protein TNP1; POU5F1; CA1; PIPOX; FCRL4; EHMT1; ASMTL; PBX1; NMUR2; PPARD

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3