il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CSF1R; CCL5; CCL4L1; TNFRSF10D; CCL27B; IFNA2; IFNA16; IL15; IL12B; CD70
Chemokine signaling pathway
CDC42; RASGRP2; CCL4L2; PRKCB; GM2506; GRB2; CCL22; SHC1; GNG5; CCR8
NF-kappa B signaling pathway
CD14; CCL4L2; CXCL12; MAP3K14; TNFSF11; CD40; TNFRSF1A; ICAM1; MYD88; IRAK4
Phospholipase D signaling pathway
PIK3R1; LPAR2; AVPR1B; DGKZ; PRKCA; AKT1; KITLG; RRAS; PIK3CD; KIT
Toll-like receptor signaling pathway
MAPK8; TAB2; IFNA16; MAPK13; IFNB1; IFNA17; RIPK1; MAPK3; TLR9; IFNA1
NOD-like receptor signaling pathway
CASP8; TNFAIP3; PSTPIP1A; IL8L1; NLRP3; MAPK10; MAPK12B; MAPK9; CCL5; MAPK12
RIG-I-like receptor signaling pathway
TBKBP1; IFNPHI3; MAPK8A; IFNA6; IFNA1; IFNA3; OTUD5A; RELA; IFNA7; IFNA14
Non-alcoholic fatty liver disease (NAFLD)
NDUFA6; PIK3CA; NDUFB5; COX8C; PIK3R3; NDUFB8; PIK3CG; PIK3CD; NDUFB7; NDUFS8
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1B1; TJP1; ATP6V1C2; MET; ADAM17; IKBKB; NOD1; JAM3; MAPK9; MAPK13
Shigellosis
RELA; DIAPH1; RAC1; MAPK10; PFN2; BTRC; WAS; PFN3; VCL; MAPK8
Salmonella infection
WASLB; MYH10; RAB7; CDC42L; PKN3; MAPK8B; TLR5B; DYNC2H1; CXCL8B.3; CASPA
Pertussis
MAPK12; PYCARD; IRF3; Il23a; Il12b; IRF1; CALM3; C4BP; IRAK4; C4BPA; NLRP3
Legionellosis
IL12A; HSPA1B; NAIP6; RELA; RAB1B; IL1B; TNF; CD14; IL6; NLRC4
Chagas disease (American trypanosomiasis)
IRAK1; FAS; PIK3R2; IL1B2; C1QB; LOC100033925; CCL5; PIK3CB; MAPK11; IKBKG
Malaria
ITGB2; VCAM1; GYPA; IL18; THBS1; ITGAL; Ccl12; IL12A; COMP; THBS3
Amoebiasis
SERPINB1B; COL1A2; IL6; COL5A1; GNA14; CD1d1; HSPB1; COL1A1; SERPINB13; RAB7
Hepatitis C
IFNA7; TNFRSF1A; NFKBIA; SCARB1; IFIT1; PPP2R2A; IFNAR1; MAVS; IFN-a; SOS1
Hepatitis B
TGFB3; ELK1; PTEN; CREB5; IFNA7; IFNB1; PIK3R2; SRC; TBK1; Casp3
Influenza A
KPNA2; PIK3CG; TLR7; EIF2AK4; ACTB; RAE1; CCL5; MAPK9; TNFRSF10C; TMPRSS13
Pathways in cancer
AKT2; BAD; GSTP1; FGF7; BIRC7; LPAR5; BDKRB1; GNG3; NKX3; TRAF5
Transcriptional misregulation in cancer
HDAC1; NCOR1; TAF15; ATM; PRCC; REL; TFE3; FLT3; KLF3; CD86
Bladder cancer
KRAS; MMP1A; CCND1; MMP2; MAP2K1; MYC; TYMP; MAPK3; THBS1; E2F2
Rheumatoid arthritis
IL1A; ACP5; IL6; ITGB2L; TNFRSF11A; TEK; CCL5; TNF; TNFSF13; CXCL6

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CXCL14; CCL38A.4; CCL21; CCL21B; CCL14; CCL20B; CCL19; CCL19B; CCL33.2; CXCL11
Function interleukin-8 receptor binding
Related Protein IL-8; MADD; YARS
Function protein binding
Related Protein RPS27; FXYD7; SFN; KRAS; KLF6; TRIM33; ANXA2; PIK3CA; OCA2; GLA

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3