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ILF3

  • Official Full Name

    interleukin enhancer binding factor 3, 90kDa

  • Overview

    This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms

    ILF3; interleukin enhancer binding factor 3, 90kDa; interleukin enhancer binding factor 3, 90kD; interleukin enhancer-binding factor 3; DRBP76; M phase phosphoprotein 4; MPHOSPH4; MPP4; NF90; NFAR 1; M-phase phosphoprotein 4; translational control protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ILF3-29491TH Recombinant Human ILF3, His-tagged E.coli His
Human ILF3-1271H Recombinant Human ILF3, GST-tagged E.coli GST 8-343aa
Human ILF3-2710H Recombinant Human ILF3 protein, His & T7-tagged E.coli His/T7 Tyr672~Tyr891 (Accession # Q12906)
Human ILF3-5221HCL Recombinant Human ILF3 293 Cell Lysate HEK293 N/A
Human ILF3-5794HF Recombinant Full Length Human ILF3 Protein, GST-tagged In Vitro Cell Free System GST 158 amino acids
Human ILF3-1129HFL Recombinant Full Length Human ILF3 Protein, C-Flag-tagged Mammalian cells Flag
Human ILF3-1182H Recombinant Human ILF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ILF3-5160H Recombinant Human ILF3 Protein, GST-tagged Wheat Germ GST
Human ILF3-1182H-B Recombinant Human ILF3 Protein Pre-coupled Magnetic Beads HEK293
Human ILF3-3010H Recombinant Human ILF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ILF3-2767H Recombinant Human ILF3 Protein (Tyr672-Tyr891), N-His tagged E.coli N-His Tyr672-Tyr891
Mouse ILF3-8186M Recombinant Mouse ILF3 Protein Mammalian Cell His
Mouse ILF3-4524M-B Recombinant Mouse ILF3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ILF3-4524M Recombinant Mouse ILF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ilf3-1248M Recombinant Mouse Ilf3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ILF3-3051R Recombinant Rat ILF3 Protein Mammalian Cell His
Rat ILF3-2707R Recombinant Rat ILF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ILF3-2707R-B Recombinant Rat ILF3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ILF3 involved in several pathways and played different roles in them. We selected most pathways ILF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ILF3 has several biochemical functions, for example, DNA binding, RNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILF3 itself. We selected most functions ILF3 had, and list some proteins which have the same functions with ILF3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingOTX1B;HIST1H3H;THAP11;HELZ2;FOXD5;STAT5B;TOP3B;DMRT2B;FAM60AL
RNA bindingTRIM21;SRP68;ZNF385D;TRNAU1APB;PTBP1;CSTF2;RNMTL1B;THOC6;THOC7
double-stranded RNA bindingRNASEN;DICER1;APTX;OAS1;ELAVL1;SUPV3L1;CLTC;RFTN1;TLR3
poly(A) RNA bindingFAM32A;NOC4L;RBM38;UBFD1;ZNFX1;HIST1H1E;MAZ;POLRMT;LYAR
protein bindingSORT1;HIST2H3C2;DICER1;NLGN4X;LACE1;SDC4;MATR3;KIAA0247;OXR1

ILF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ILF3.

YBX1; ILF2; VP35; PRMT1; VCAM1

  • Q&As
  • Reviews

Q&As (6)

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Which tumors are associated with ILF3? What role does it play in tumor development? 12/07/2019

This is associated with a variety of tumors, including breast cancer, lung cancer, and colon cancer. In tumor development, ILF3 may promote cell proliferation, apoptosis inhibition, and metastasis.

What progress has been made in the exploration of new methods and new drugs for ILF3 treatment of tumors? 11/04/2019

At present for ILF3 new treatment for cancer and new drug exploration is still in its infancy, but some ILF3 related drugs and treatment strategies are in development and evaluation, bring new hope for patients.

Is ILF3 associated with tumor microenvironment and immune escape? 10/29/2019

This peotein may be associated with tumor microenvironment and immune escape, and can regulate the interaction between tumor cells and immune cells, further deepening our understanding of the mechanism of immune escape.

Is there a relationship between LF3 and tumor prognosis and treatment response? 06/29/2019

The association between ILF3 and tumor prognosis and treatment response needs to be further studied, but according to the current study, high expression of ILF3 may be associated with poor prognosis and drug resistance in cancer patients.

What are the functions and mechanisms of ILF3 in infectious diseases? 04/23/2019

ILF3 may play an important immunomodulatory function in infectious diseases and may be involved in the immune response and inflammatory response caused by viral or bacterial infection.

What is ILF3 role in autoimmune diseases? What autoimmune diseases might it be involved in? 01/14/2019

It may play an important role in autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (sle), may be involved in these diseases by means of immune regulation of occurrence and development.

Customer Reviews (3)

Write a review
Reviews
07/17/2022

    The impurities are not obvious, clear and transparent, and the purity is high.

    07/13/2022

      It can meet the needs of daily experiments, and the expression effect is good.

      02/27/2021

        ILF3 has performed well in experiments and is a reliable choice.

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