| Cat.No. : |
ILF3-5160H |
| Product Overview : |
Human ILF3 full-length ORF ( AAH03086, 1 a.a. - 158 a.a.) recombinant protein with GST-tag at N-terminal. |
| Description : |
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
43.12 kDa |
| AA Sequence : |
MCSCPISSPG HIKGLGQEET PVRSADLVFK ERMPACNTHG EGHFLAPPAK YLQTLGRRLH SQHRTSLNSF RISDHHHVQV SECRPTTRDG FHPPALLQIH AAQQARAWRE QLLSTAPLEP SPRSRSSPVL MMPSCCWPET VSQLQQDDTG FRNMWLSP |
| Applications : |
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Quality Control Testing : |
12.5% SDS-PAGE Stained with Coomassie Blue
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