traf1
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  • Official Full Name
  • TNF receptor-associated factor 1
  • Background
  • TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the
  • Synonyms
  • TRAF1; TNF receptor-associated factor 1; EBI6; Epstein-Bar virus-induced protein 6; MGC:10353
Cat.#:TRAF1-389HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF1 Protein, His/GST-tagged
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Cat.#:Traf1-390MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Traf1 Protein, His-tagged
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Cat.#:TRAF1-2478HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNF Receptor-associated Factor 1, His-tagged
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Cat.#:TRAF1-29978THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF1, His-tagged
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Cat.#:TRAF1-31600THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF1, His-tagged
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Cat.#:TRAF1-17283MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF1 Protein
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Cat.#:TRAF1-4930RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRAF1 Protein, His-tagged
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Cat.#:TRAF1-6882ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRAF1
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Cat.#:TRAF1-825HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF1 293 Cell Lysate
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Involved Pathway

TRAF1 involved in several pathways and played different roles in them. We selected most pathways TRAF1 participated on our site, such as NF-kappa B signaling pathway, TNF signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
LAT; ERC1; IKBKB; NFKBIA; BIRC3; LTBR; TNFSF11; CCL13; CFLAR; RELA
TNF signaling pathway
MAP3K7IP3; MAP3K5; MAP2K7; MAP3K7; ITCH; MAP2K6; MAPK10; MMP9; BAG4; DNM1L
Herpes simplex infection
TRAF2; HLA-E; MHC2DAB; SOCS3B; HLA-DQB1; TAB2; TBPL1; SRSF6A; PVRL1; CUL1B
Epstein-Barr virus infection
YWHAH; PIK3CA; PSMD2; HSPA1A; MAP2K4; IRF3; HLA-DRB3; POLR3GL; EIF2AK4; PIK3R3
Pathways in cancer
FASLG; PLCB2; PRKCA; TGFB3; PLD1; MAPK8; DAPK3; IGF1R; NRAS; LAMA5
Transcriptional misregulation in cancer
TSPAN7; RARA; ERG; PTK2; ZBTB17; HIST1H3D; DEFA3; FLT1; NR4A3; ITGAM
Viral carcinogenesis
BAX; STAT5A; EIF2AK2; NFKB1; GRB2; HDAC10; PKM2; H2-Q10; HIST1H2BA; IKBKG
Small cell lung cancer
MAX; LAMB4; ITGB1; PIK3R5; LAMA3; TRAF5; PIK3R2; TP53; PTEN; PIK3CD

Protein Function

TRAF1 has several biochemical functions, for example, protein binding, thioesterase binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF1 itself. We selected most functions TRAF1 had, and list some proteins which have the same functions with TRAF1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein KEL; BAG1; PPIG; NEDD4; MS4A12; PTBP1; DUSP9; NUCB1; RTKN; DSG1A
Function thioesterase binding
Related Protein HAUS7; TRAF4; TRAF6; TRAF1; RAC1; CDC42; TRAF3; CALM3; TRAF5; CALM2
Function tumor necrosis factor receptor binding
Related Protein TNFSF13; CD70; TRAF1; TRAF6; EDA; TNFSF11; BRE; TRAP1; TNFSF13B; TRIM37
Function ubiquitin protein ligase binding
Related Protein MAGEA2; CUL2; WASH1; GLMN; PACRG; DLG3; UBXN1; UBE2T; RNF20; TPI1
Function zinc ion binding
Related Protein ACE; FTR14; GM757; NR1H2; RNF17; MSRB3; RNF44; IFIH1; RBM4; DEF8

Interacting Protein

TRAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF1.
TRAF6; RIPK1; TRAF2

TRAF1 Related Articles

Lassen, UN; Meulendijks, D; et al. APhase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers. CLINICAL CANCER RESEARCH 21:258-266(2015).
Settin, A; Salama, A; et al. Signal transducer and activator of transcription 4 (STAT4) G > T gene polymorphism in Egyptian cases with rheumatoid arthritis. HUMAN IMMUNOLOGY 75:863-866(2014).