ago1
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  • Official Full Name
  • argonaute RISC catalytic component 1
  • Background
  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4. [provided by RefSeq, Jul 2008]
  • Synonyms
  • AGO1; argonaute RISC catalytic component 1; Q99; EIF2C; EIF2C1; GERP95; protein argonaute-1; hAgo1; eIF2C 1; eIF-2C 1; argonaute1; argonaute 1; putative RNA-binding protein Q99; Golgi Endoplasmic Reticulum protein 95 kDa; eukaryotic translation initiation factor 2C, 1;
Cat.#:AGO1-3161HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGO1 Protein, GST-tagged
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Cat.#:AGO1-1393HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGO1 protein, His & T7-tagged
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Cat.#:AGO1-693HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AGO1 cell lysate
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Involved Pathway

AGO1 involved in several pathways and played different roles in them. We selected most pathways AGO1 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
RAPGEF4; KIF3B; LRRC41; UFL1; CTSE; PTBP3; KLRB1B; PPIAL4A; ASB13; IGHM
Beta-catenin independent WNT signaling
AGO2; MOV10; CLTC; AGO3; CTNNB2; ROR2; AGO1; AP2M1; CLTB; DVL2
Ca2+ pathway
AGO2; AGO1; GNB5; MOV10; AGO3
Cellular Senescence
CDKN2D; HIST1H1A; HIST1H1E; Txn1; HIRA; RAD50; PHC1; ERF; CBX6; ACD
Cellular responses to stress
GABARAP; CABIN1; DYNLL2A; POT1; CDK6; ERF; EPAS1B; ATG7; KIAA1967; HIST1H1B
DAP12 interactions
PEBP1; CNKSR1; DUSP10; KBTBD7; FRS2; FGF10B; DUSP2; PEA15A; CSF2RA; DUSP5
DAP12 signaling
KLB; SPTBN1; NRG3; JAK3; DUSP6; CSF2RB; THEM4; FGF20A; GRAP2A; SPRED2
Downstream signal transduction
FRS3; KBTBD7; JAK1; CRKL; WDR83; PEA15; AGO3; FGF20A; SPTA1; PEBP1

Protein Function

AGO1 has several biochemical functions, for example, RNA binding, RNA polymerase II core binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO1 itself. We selected most functions AGO1 had, and list some proteins which have the same functions with AGO1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein MCTS2; CELF6; DKC1; PTBP1A; CPSF1; KHSRP; CSTF3; QKIA; HNRNPR; ZRANB2
Function RNA polymerase II core binding
Related Protein CTR9; KIAA1530; PAF1; RECQL5; KIAA1967; SMYD3; RPRD1B; ZNF326; PCF11; SMYD2A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TLX1; ELF3; TCF7L2; TXK; CC2D1A; ELF4; PPARA; FOXA2; HIST2H3A; NR2C1
Function core promoter binding
Related Protein INSM1B; RB1; SPI1; HDAC6; NONO; NKX3-1; SAFB; XBP1; MTA1; KDM3A
Function double-stranded RNA binding
Related Protein OAS1; TUBA1B; AGO1; MYH4; ZNF346; ILF3; TARBP2; MBNL1; OASL; TUBB4B
Function NOT endoribonuclease activity
Related Protein AGO1
Function miRNA binding
Related Protein EIF2C3; RBM4; DICER1; AGO2; AGO3; MEF2C; AGO4; TARBP2; SOX2; POU5F1
Function poly(A) RNA binding
Related Protein PUF60; RPS26; SART1; MTERF; RPS6; SRP54; TUFM; MRPS9; PPIL4; ELAC2
Function protein binding
Related Protein DES; FUT11; TLE3; CRMP1; CTU2; PIM2; TCHP; GNB5; HUWE1; C5orf30
Function single-stranded RNA binding
Related Protein AGO1; HMGB1; EIF2C3; NXF1; POLR2GL; STRBP; ANXA1; RBMX; LONP1; PIWIL1

Interacting Protein

AGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO1.
DICER1; TNRC6A; HSP90AB1; PABPC1; TARBP2; IPO8

AGO1 Related Articles

Laneve, P; Delaporte, C; et al. The Gcm/Glide molecular and cellular pathway: New actors and new lineages. DEVELOPMENTAL BIOLOGY 375:65-78(2013).
Dallas, A; Ilves, H; et al. Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. NUCLEIC ACIDS RESEARCH 40:9255-9271(2012).