Recombinant Human AGO1 Protein, GST-tagged
Cat.No. : | AGO1-3161H |
Product Overview : | Human EIF2C1 full-length ORF ( NP_036331.1, 1 a.a. - 857 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 123.6 kDa |
AA Sequence : | MEAGPSGAAAGAYLPPLQQVFQAPR RPGIGTVGKPIKLLANYFEVDIPKI DVYHYEVDIKPDKCPRRVNREVVEY MVQHFKPQIFGDRKPVYDGKKNIYT VTALPIGNERVDFEVTIPGEGKDRI FKVSIKWLAIVSWRMLHEALVSGQI PVPLESVQALDVAMRHLASMRYTPV GRSFFSPPEGYYHPLGGGREVWFGF HQSVRPAMWKMMLNIDVSATAFYKA QPVIEFMCEVLDIRNIDEQPKPLTD SQRVRFTKEIKGLKVEVTHCGQMKR KYRVCNVTRRPASHQTFPLQLESGQ TVECTVAQYFKQKYNLQLKYPHLPC LQVGQEQKHTYLPLEVCNIVAGQRC IKKLTDNQTSTMIKATARSAPDRQE EISRLMKNASYNLDPYIQEFGIKVK DDMTEVTGRVLPAPILQYGGRNRAI ATPNQGVWDMRGKQFYNGIEIKVWA IACFAPQKQCREEVLKNFTDQLRKI SKDAGMPIQGQPCFCKYAQGADSVE PMFRHLKNTYSGLQLIIVILPGKTP VYAEVKRVGDTLLGMATQCVQVKNV VKTSPQTLSNLCLKINVKLGGINNI LVPHQRSAVFQQPVIFLGADVTHPP AGDGKKPSITAVVGSMDAHPSRYCA TVRVQRPRQEIIEDLSYMVRELLIQ FYKSTRFKPTRIIFYRDGVPEGQLP QILHYELLAIRDACIKLEKDYQPGI TYIVVQKRHHTRLFCADKNERIGKS GNIPAGTTVDTNITHPFEFDFYLCS HAGIQGTSRPSHYYVLWDDNRFTAD ELQILTYQLCHTYVRCTRSVSIPAP AYYARLVAFRARYHLVDKEHDSGEG SHISGQSNGRDPQALAKAVQVHQDT LRTMYFA |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGO1 argonaute 1, RISC catalytic component [ Homo sapiens (human) ] |
Official Symbol : | AGO1 |
Synonyms : | AGO1; argonaute 1, RISC catalytic component; EIF2C1; eukaryotic translation initiation factor 2C, 1; protein argonaute-1; AGO1; argonaute 1; hAgo1; eIF2C 1; eIF-2C 1; argonaute1; putative RNA-binding protein Q99; Golgi Endoplasmic Reticulum protein 95 kDa; Q99; EIF2C; GERP95; DKFZp686M13167; |
Gene ID : | 26523 |
mRNA Refseq : | NM_012199 |
Protein Refseq : | NP_036331 |
MIM : | 606228 |
UniProt ID : | Q9UL18 |
Products Types
◆ Recombinant Protein | ||
AGO1-1393H | Recombinant Human AGO1 protein, His & T7-tagged | +Inquiry |
AGO1-1240H | Recombinant Human AGO1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
AGO1-693HCL | Recombinant Human AGO1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (21)
Ask a questionAGO1’s activity impacts neuronal development and synaptic plasticity.
AGO1 helps control gene expression by degrading or inhibiting mRNA translation.
AGO1 dysfunction is linked to disorders involving impaired gene regulation.
Research explores AGO1’s role in guiding small RNAs to their target sequences.
Yes, AGO1’s activity leads to the suppression or degradation of target mRNAs.
Yes, AGO1’s function is linked to post-transcriptional regulation of circadian genes.
Yes, AGO1 is part of the antiviral RNA interference pathway.
Yes, AGO1’s function is important for maintaining stem cell populations.
Yes, AGO1 is involved in suppressing transposable element activity.
AGO1 participates in RNA quality control mechanisms, preventing aberrant RNA transcripts.
Research explores AGO1’s contribution to targeting RNAs for exosome-mediated decay.
Research explores how AGO1 guides small RNAs to complementary target mRNA sequences.
Yes, AGO1 is involved in regulating immune responses through gene silencing.
Yes, AGO1’s activity can influence heterochromatin formation and genome stability.
Research investigates AGO1’s connection to chromatin remodeling complexes.
Yes, AGO1’s role extends to epigenetic regulation through RNA-directed DNA methylation.
AGO1’s activity leads to translational repression through mRNA cleavage or inhibition.
Yes, AGO1’s activity can be regulated in response to cellular stress.
Yes, AGO1 is essential for normal development and cellular processes.
Yes, AGO1’s role in gene regulation is relevant in cancer studies.
Research investigates AGO1’s role in regulating germline development and fertility.
Customer Reviews (5)
Write a reviewThe protein product consistently yielded the expected outcomes, bolstering our experimental results.
Notable improvements in cell proliferation were attributed to the protein product’s efficacy.
Minimal background noise in our assays indicated the protein product’s quality.
We observed a significant enhancement in enzyme activity using the protein product.
Reliable protein-protein interaction studies were enabled by the protein product’s pure composition.
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