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Recombinant Human AGO1 Protein, GST-tagged

Cat.No. : AGO1-3161H
Product Overview : Human EIF2C1 full-length ORF ( NP_036331.1, 1 a.a. - 857 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 123.6 kDa
AA Sequence : MEAGPSGAAAGAYLPPLQQVFQAPR RPGIGTVGKPIKLLANYFEVDIPKI DVYHYEVDIKPDKCPRRVNREVVEY MVQHFKPQIFGDRKPVYDGKKNIYT VTALPIGNERVDFEVTIPGEGKDRI FKVSIKWLAIVSWRMLHEALVSGQI PVPLESVQALDVAMRHLASMRYTPV GRSFFSPPEGYYHPLGGGREVWFGF HQSVRPAMWKMMLNIDVSATAFYKA QPVIEFMCEVLDIRNIDEQPKPLTD SQRVRFTKEIKGLKVEVTHCGQMKR KYRVCNVTRRPASHQTFPLQLESGQ TVECTVAQYFKQKYNLQLKYPHLPC LQVGQEQKHTYLPLEVCNIVAGQRC IKKLTDNQTSTMIKATARSAPDRQE EISRLMKNASYNLDPYIQEFGIKVK DDMTEVTGRVLPAPILQYGGRNRAI ATPNQGVWDMRGKQFYNGIEIKVWA IACFAPQKQCREEVLKNFTDQLRKI SKDAGMPIQGQPCFCKYAQGADSVE PMFRHLKNTYSGLQLIIVILPGKTP VYAEVKRVGDTLLGMATQCVQVKNV VKTSPQTLSNLCLKINVKLGGINNI LVPHQRSAVFQQPVIFLGADVTHPP AGDGKKPSITAVVGSMDAHPSRYCA TVRVQRPRQEIIEDLSYMVRELLIQ FYKSTRFKPTRIIFYRDGVPEGQLP QILHYELLAIRDACIKLEKDYQPGI TYIVVQKRHHTRLFCADKNERIGKS GNIPAGTTVDTNITHPFEFDFYLCS HAGIQGTSRPSHYYVLWDDNRFTAD ELQILTYQLCHTYVRCTRSVSIPAP AYYARLVAFRARYHLVDKEHDSGEG SHISGQSNGRDPQALAKAVQVHQDT LRTMYFA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AGO1 argonaute 1, RISC catalytic component [ Homo sapiens (human) ]
Official Symbol : AGO1
Synonyms : AGO1; argonaute 1, RISC catalytic component; EIF2C1; eukaryotic translation initiation factor 2C, 1; protein argonaute-1; AGO1; argonaute 1; hAgo1; eIF2C 1; eIF-2C 1; argonaute1; putative RNA-binding protein Q99; Golgi Endoplasmic Reticulum protein 95 kDa; Q99; EIF2C; GERP95; DKFZp686M13167;
Gene ID : 26523
mRNA Refseq : NM_012199
Protein Refseq : NP_036331
MIM : 606228
UniProt ID : Q9UL18

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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How does AGO1’s role relate to neuronal function 04/02/2022

AGO1’s activity impacts neuronal development and synaptic plasticity.

How does AGO1’s role relate to post-transcriptional regulation 11/13/2021

AGO1 helps control gene expression by degrading or inhibiting mRNA translation.

How does AGO1’s dysfunction relate to diseases 08/31/2021

AGO1 dysfunction is linked to disorders involving impaired gene regulation.

How is AGO1’s function studied in RNA silencing 03/22/2021

Research explores AGO1’s role in guiding small RNAs to their target sequences.

Can AGO1 influence gene expression 12/15/2020

Yes, AGO1’s activity leads to the suppression or degradation of target mRNAs.

Can AGO1’s activity affect circadian rhythm regulation 10/03/2020

Yes, AGO1’s function is linked to post-transcriptional regulation of circadian genes.

Can AGO1’s activity be involved in antiviral defense 02/11/2020

Yes, AGO1 is part of the antiviral RNA interference pathway.

Can AGO1 influence stem cell maintenance 11/07/2019

Yes, AGO1’s function is important for maintaining stem cell populations.

Can AGO1 impact transposable element silencing 05/23/2018

Yes, AGO1 is involved in suppressing transposable element activity.

How does AGO1’s role connect to RNA quality control 04/09/2018

AGO1 participates in RNA quality control mechanisms, preventing aberrant RNA transcripts.

How is AGO1’s role in exosome-mediated RNA decay studied 11/20/2017

Research explores AGO1’s contribution to targeting RNAs for exosome-mediated decay.

How is AGO1’s interaction with target mRNAs studied 11/09/2017

Research explores how AGO1 guides small RNAs to complementary target mRNA sequences.

Can AGO1’s activity regulate immune responses 08/21/2017

Yes, AGO1 is involved in regulating immune responses through gene silencing.

Can AGO1’s function impact heterochromatin formation 04/06/2017

Yes, AGO1’s activity can influence heterochromatin formation and genome stability.

How is AGO1’s involvement in chromatin remodeling studied 03/07/2017

Research investigates AGO1’s connection to chromatin remodeling complexes.

Can AGO1 be involved in epigenetic regulation 02/12/2017

Yes, AGO1’s role extends to epigenetic regulation through RNA-directed DNA methylation.

How does AGO1’s role in translation repression work 11/09/2016

AGO1’s activity leads to translational repression through mRNA cleavage or inhibition.

Is AGO1’s activity modulated during stress responses 09/21/2016

Yes, AGO1’s activity can be regulated in response to cellular stress.

Is AGO1 essential for normal development 03/13/2016

Yes, AGO1 is essential for normal development and cellular processes.

Can AGO1’s function be studied in cancer research 02/01/2016

Yes, AGO1’s role in gene regulation is relevant in cancer studies.

How is AGO1’s involvement in germline development studied 01/29/2016

Research investigates AGO1’s role in regulating germline development and fertility.

Customer Reviews (5)

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Reviews
10/14/2021

    The protein product consistently yielded the expected outcomes, bolstering our experimental results.

    02/01/2021

       Notable improvements in cell proliferation were attributed to the protein product’s efficacy.

      01/04/2021

         Minimal background noise in our assays indicated the protein product’s quality.

        07/03/2019

           We observed a significant enhancement in enzyme activity using the protein product.

          09/11/2017

             Reliable protein-protein interaction studies were enabled by the protein product’s pure composition.

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