IGFBP2
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Official Full Name
insulin-like growth factor binding protein 2, 36kDa
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Overview
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. -
Synonyms
IGFBP2; insulin-like growth factor binding protein 2, 36kDa; IBP2; IGF-BP53; insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Bovine
- Cattle
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Insect Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- yeast
- C
- hFc
- Flag
- FLAG
- His
- His (Fc)
- Avi
- His(C
- ter)
- His|GST
- His|S
- His|T7
- Met
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- IGFBP2 Related Articles
- IGFBP2 Related Research Area
IGFBP2 involved in several pathways and played different roles in them. We selected most pathways IGFBP2 participated on our site, such as Metabolism of proteins, Myometrial Relaxation and Contraction Pathways, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism of proteins | PAPPAB;GRP;LMCD1;FKBP14;ANKRD28;TIMM10;DMBT1;SPON1B;SMC5 |
Myometrial Relaxation and Contraction Pathways | RAMP1;RGS4;MAFF;PKIB;ATF5;RGS17;IGFBP5;RGS11;GABPB1 |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | PAPPAB;IGFBP6;KLK13;PAPPA;IGFBP1B;IGFBP6A;IGFBP4;IGFBP2A;PAPPA2 |
IGFBP2 has several biochemical functions, for example, insulin-like growth factor I binding, insulin-like growth factor II binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP2 itself. We selected most functions IGFBP2 had, and list some proteins which have the same functions with IGFBP2. You can find most of the proteins on our site.
Function | Related Protein |
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insulin-like growth factor I binding | IGFBP2A;IGFBP3;IGFBP2;IGFBP1B;IGFBP5A;IGFBP1A;IGFBP6A;IGFBP6B;IGFBP6 |
insulin-like growth factor II binding | IGFBP5B;IGFBP4;IGFBP1A;IGFBP1B;INSR;IGFBP5;IGFBP2A;IGFBP2B;IGFBP6B |
protein binding | DYRK1A;CPSF2;KRT20;TDRD7;TMEM115;TFAM;Tnfrsf22;ELN;CRYAA |
IGFBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP2.
INO80B; aroP; GSDMB
- Q&As
- Reviews
Q&As (5)
Ask a questionIGFBP2 levels can be measured using various laboratory techniques, including ELISA (Enzyme-Linked Immunosorbent Assay) and Western blotting.
Yes, IGFBP2 has been implicated in neurological disorders and metabolic diseases, making it a potential target for therapeutic interventions in these conditions.
Genetic variations in the IGFBP2 gene have been identified and may contribute to individual differences in disease susceptibility and treatment responses.
IGFBP2 binds to insulin-like growth factors, regulating their bioavailability and modulating their effects on cell growth and survival.
Research suggests that elevated levels of IGFBP2 may serve as a diagnostic marker for early cancer detection, but more studies are needed to validate its clinical utility.
Customer Reviews (3)
Write a reviewWhether it's protein quantification, structural analysis, or Western Blotting, the IGFBP2 protein has consistently delivered exceptional results, earning my highest recommendation.
The IGFBP2 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.
Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.
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