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IGFBP2

  • Official Full Name

    insulin-like growth factor binding protein 2, 36kDa

  • Overview

    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Synonyms

    IGFBP2; insulin-like growth factor binding protein 2, 36kDa; IBP2; IGF-BP53; insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • yeast
  • C
  • hFc
  • Flag
  • FLAG
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • His|S
  • His|T7
  • Met
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGFBP2-29545TH Active Recombinant Human IGFBP2 protein Insect Cell N/A
Human IGFBP2-11H Active Recombinant Human IGFBP2 yeast N/A
Human IGFBP2-477H Active Recombinant Human IGFBP2, Met-tagged Mammalian cells Met
Human IGFBP2-5049H Active Recombinant Human Insulin-Like Growth Factor Binding Protein 2, 36kDa Human N/A
Human IGFBP2-824H Recombinant Human IGFBP2 protein, His & T7-tagged E.coli His/T7 Asp148~Gln325
Human IGFBP2-1388H Recombinant Human IGFBP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IGFBP2-02H Recombinant Human IGFBP2 Protein, His-tagged E. coli His 36-325
Human IGFBP2-5679H Recombinant Human IGFBP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IGFBP2-25H Recombinant Human IGFBP2 protein, FLAG-tagged Mammalian cell FLAG
Human IGFBP2-132H Recombinant Human IGFBP2 Protein, His-tagged(C-ter) HEK293 His(C-ter) Glu40-Gln328
Human IGFBP2-32H Recombinant Human IGFBP2 Protein, His-tagged E. coli His Asp148~Gln325
Human IGFBP2-1157H-B Recombinant Human IGFBP2 Protein Pre-coupled Magnetic Beads HEK293
Human IGFBP2-31H Recombinant Human IGFBP2 Protein, His-tagged E. coli His 76-328 aa
Human IGFBP2-991H Recombinant Human IGFBP2 Protein, His-tagged HEK293F N-His Asp148-Gln325
Human IGFBP2-185I Active Recombinant Human IGFBP2 Protein, His-tagged HEK293 His
Human IGFBP2-1059HFL Recombinant Full Length Human IGFBP2 Protein, C-Flag-tagged Mammalian cells Flag
Human IGFBP2-1236H Active Recombinant Human IGFBP2 protein, His-tagged HEK293 His Glu40-Gln328
Human IGFBP2-1157H Recombinant Human IGFBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Igfbp2-1749M Recombinant Mouse Insulin-like Growth Factor Binding Protein 2 Mammalian cells N/A
Mouse Igfbp2-825M Recombinant Mouse Igfbp2 protein, His & GST-tagged E.coli His/GST Ala34~Gln305 (Accession # P47877)
Mouse IGFBP2-8072M Recombinant Mouse IGFBP2 Protein Mammalian Cell His
Mouse Igfbp2-969M Active Recombinant Mouse Igfbp2 protein(Met1-Gln305), hFc-tagged HEK293 C-hFc Met1-Gln305
Mouse Igfbp2-970M Recombinant Mouse Igfbp2 Protein, His-tagged HEK293 His
Mouse Igfbp2-990M Recombinant Mouse Igfbp2 Protein, His-tagged HEK293F N-His Ala34-Gln305
Mouse Igfbp2-10569M Recombinant Mouse Igfbp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Igfbp2-1227M Recombinant Mouse Igfbp2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Igfbp2-10569M-B Recombinant Mouse Igfbp2 Protein Pre-coupled Magnetic Beads HEK293
Rat IGFBP2-3008R Recombinant Rat IGFBP2 Protein Mammalian Cell His
Rat Igfbp2-826R Recombinant Rat Igfbp2 protein, His & S-tagged E.coli His/S Glu35~Gln304 (Accession # P12843)
Rat IGFBP2-2664R Recombinant Rat IGFBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IGFBP2-2664R-B Recombinant Rat IGFBP2 Protein Pre-coupled Magnetic Beads HEK293
Bovine IGFBP2-1414B Recombinant Bovine Insulin-Like Growth Factor Binding Protein 2, 36kDa CHO N/A
Cattle IGFBP2-993C Recombinant Cattle IGFBP2 Protein, His-tagged E.coli N-His Glu34-Gln317
Cynomolgus Monkey IGFBP2-1457CCL Recombinant Cynomolgus IGFBP2 cell lysate Human Cell N/A
Rhesus Macaque IGFBP2-1188R Active Recombinant Rhesus IGFBP2 Protein, His-tagged HEK293 His
Pig IGFBP2-992P Recombinant Pig IGFBP2 Protein, His-tagged E.coli N-His Glu30-Gln316
Chicken IGFBP2-6911C Recombinant Chicken IGFBP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGFBP2 Related Articles
  • IGFBP2 Related Research Area

IGFBP2 involved in several pathways and played different roles in them. We selected most pathways IGFBP2 participated on our site, such as Metabolism of proteins, Myometrial Relaxation and Contraction Pathways, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsPAPPAB;GRP;LMCD1;FKBP14;ANKRD28;TIMM10;DMBT1;SPON1B;SMC5
Myometrial Relaxation and Contraction PathwaysRAMP1;RGS4;MAFF;PKIB;ATF5;RGS17;IGFBP5;RGS11;GABPB1
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PAPPAB;IGFBP6;KLK13;PAPPA;IGFBP1B;IGFBP6A;IGFBP4;IGFBP2A;PAPPA2

IGFBP2 has several biochemical functions, for example, insulin-like growth factor I binding, insulin-like growth factor II binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP2 itself. We selected most functions IGFBP2 had, and list some proteins which have the same functions with IGFBP2. You can find most of the proteins on our site.

Function Related Protein
insulin-like growth factor I bindingIGFBP2A;IGFBP3;IGFBP2;IGFBP1B;IGFBP5A;IGFBP1A;IGFBP6A;IGFBP6B;IGFBP6
insulin-like growth factor II bindingIGFBP5B;IGFBP4;IGFBP1A;IGFBP1B;INSR;IGFBP5;IGFBP2A;IGFBP2B;IGFBP6B
protein bindingDYRK1A;CPSF2;KRT20;TDRD7;TMEM115;TFAM;Tnfrsf22;ELN;CRYAA

IGFBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP2.

INO80B; aroP; GSDMB

Kang, Z; Yu, Y; et al. Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. ONCOGENE 33:5697-5705(2014).
Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How can IGFBP2 levels be measured in clinical settings? 08/15/2022

IGFBP2 levels can be measured using various laboratory techniques, including ELISA (Enzyme-Linked Immunosorbent Assay) and Western blotting.

Are there other diseases where IGFBP2 plays a significant role? 04/09/2022

Yes, IGFBP2 has been implicated in neurological disorders and metabolic diseases, making it a potential target for therapeutic interventions in these conditions.

Are there genetic variations in IGFBP2 that influence its clinical significance? 08/25/2020

Genetic variations in the IGFBP2 gene have been identified and may contribute to individual differences in disease susceptibility and treatment responses.

How does IGFBP2 interact with insulin-like growth factors? 12/30/2018

IGFBP2 binds to insulin-like growth factors, regulating their bioavailability and modulating their effects on cell growth and survival.

Can IGFBP2 be used as a diagnostic marker for early cancer detection? 03/13/2016

Research suggests that elevated levels of IGFBP2 may serve as a diagnostic marker for early cancer detection, but more studies are needed to validate its clinical utility.

Customer Reviews (3)

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Reviews
01/02/2023

    Whether it's protein quantification, structural analysis, or Western Blotting, the IGFBP2 protein has consistently delivered exceptional results, earning my highest recommendation.

    06/29/2016

      The IGFBP2 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

      04/07/2016

        Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.

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