Active Recombinant Human Insulin-Like Growth Factor Binding Protein 2, 36kDa

• Cat.No.: IGFBP2-5049H
• Product Overview: Recombinant Human IGFBP2 was expressed in Hi-5 Insect cells and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of IGF BP2 protein corresponding to amino acids EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KL
• Molecular Mass: 31.5 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IGFBP2 insulin-like growth factor binding protein 2, 36kDa [ Homo sapiens ]
• Official Symbol: IGFBP2
• Synonyms: insulin-like growth factor binding protein 2, 36kDa; IBP2; IGF-BP53; IGFBP2; BP2; IBP-2; IGFBP-2; IGF-binding protein 2; insulin-like growth factor binding protein 2 (36kD); OTTHUMP00000207751; OTTHUMP00000207753
• Gene ID: 3485
• mRNA Refseq: NM_000597
• Protein Refseq: NP_000588
• MIM: 146731
• UniProt ID: P18065
• Chromosome Location: 2q33-q34
• Pathway: Diabetes pathways; Myometrial Relaxation and Contraction Pathways; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
• Function: insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding