Active Recombinant Human IGFBP2 protein

• Cat.No.: IGFBP2-29545TH
• Product Overview: Recombinant Human IGFBP2 was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.
• Form: Sterile filtered through a 0.2 micron filter. Lypholizied fron 1 x PBS, pH 7.2.
• Bio-activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
• AA Sequence: EVLFRCPPC TPERLAACG PPPVAPPAA VAAVAGGAR MPCAELVRE PGCGCCSVC ARLEGEACQ VYTPRCGQG LRCYPHPGS ELPLQALVM GEGTCEKRR DAEYGASPE QVADNGDDH SEGGLVENH VDSTMNMLG GGGSAGRKP LKSGMKELA VFREKVTEQ HRQMGKGGK HHLGLEEPK KLRPPPART PCQQELDQV LERISTMRL PDERGPLEH LYSLHIPNC DKHGLYNLK QCKMSLNGQ RGECWCVNP NTGKLIQGA PTIRGDPEC HLFYNEQQE ARGVHTQRM Q
• Endotoxin: < 1 EU/ug
• Purity: Above 98% as determined by SDS-PAGE Analysis.
• Storage: Store at -20 centigrade.
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Store at 2 centigrade to 8 centigrade for 1 week, or prepare for extended storage. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein(example 0.1& BSA) and store in working aliquots at -20 centigrade to -80 centigrade. Avoid repeated freeze-thaw cycles.
• Publications:
  Effects Of IGFs On Beta-Cell Proliferation In Ovine Models Exposed To Intrauterine Growth Restriction (2019)

Gene Information

• Gene Name: IGFBP2 insulin-like growth factor binding protein 2, 36kDa [ Homo sapiens ]
• Official Symbol: IGFBP2
• Synonyms: IGFBP2; insulin-like growth factor binding protein 2, 36kDa; IBP2, insulin like growth factor binding protein 2 (36kD); insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2; IBP2; IGF-BP53
• Gene ID: 3485
• mRNA Refseq: NM_000597
• Protein Refseq: NP_000588
• MIM: 146731
• UniProt ID: P18065