Recombinant Mouse Igfbp2 Protein, Full Length, C-His tagged
Cat.No. : | Igfbp2-01MFL |
Product Overview : | Recombinant mouse IGFBP-2 (Full length), fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | IGFBP-2, also known as insulin-like growth factor binding protein 2, is a member of IGFBP superfamily. IGFBPs modulate the biological activities of IGF proteins and have a high affinity for IGFs. IGFBPs are not merely carrier proteins for IGFs, but hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues.This protein binds preferentially to IGF-2, exhibiting a 2 - 10 fold higher affinity for IGF-2 than for IGF-1. Also, it is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. |
Source : | HEK293 |
Species : | Mouse |
Tag : | C-His |
Protein length : | Full Length |
Form : | Liquid |
Bio-activity : | Measured by its ability to inhibit proliferation using MCF-7 human breast cancer cells in the presence of Mouse IGF-2. The ED50 range ≤ 0.7 μg/mL. |
Molecular Mass : | 30.3 kDa (277aa) |
AA Sequence : | EVLFRCPPCTPERLAACGPPPDAPC AELVREPGCGCCSVCARQEGEACGV YIPRCAQTLRCYPNPGSELPLKALV TGAGTCEKRRVGTTPQQVADSDDDH SEGGLVENHVDGTMNMLGGGSSAGR KPLKSGMKELAVFREKVNEQHRQMG KGAKHLSLEEPKKLRPPPARTPCQQ ELDQVLERISTMRLPDDRGPLEHLY SLHIPNCDKHGRYNLKQCKMSLNGQ RGECWCVNPNTGKPIQGAPTIRGDP ECHLFYNEQQETGGAHAQSVQ |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 85% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Notes : | For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/mL (determined by Absorbance at 280nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
References : | 1. Yoshiyuki H., et al, (1994) Cellular Physiology. 158:444-450. 2. Agarwal N., et al, (1991) Exp Eye Res. 52:549-561. |
Gene Name : | Igfbp2 insulin-like growth factor binding protein 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Igfbp2 |
Synonyms : | IGFBP2; insulin-like growth factor binding protein 2; insulin-like growth factor-binding protein 2; IGF-binding protein 2; IBP-2; Igfbp-2; AI255832; mIGFBP-2; |
Gene ID : | 16008 |
mRNA Refseq : | NM_008342 |
Protein Refseq : | NP_032368 |
UniProt ID : | P47877 |
Products Types
◆ Recombinant Protein | ||
IGFBP2-992P | Recombinant Pig IGFBP2 Protein, His-tagged | +Inquiry |
Igfbp2-990M | Recombinant Mouse Igfbp2 Protein, His-tagged | +Inquiry |
Igfbp2-969M | Active Recombinant Mouse Igfbp2 protein(Met1-Gln305), hFc-tagged | +Inquiry |
IGFBP2-132H | Recombinant Human IGFBP2 Protein, His-tagged(C-ter) | +Inquiry |
IGFBP2-1157H | Recombinant Human IGFBP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IGFBP2-1457CCL | Recombinant Cynomolgus IGFBP2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket