Prlr
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Official Full Name
prolactin receptor
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Overview
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] -
Synonyms
PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; PRL-R; hPRL receptor; secreted prolactin binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Oryctolagus cuniculus (Rabbit)
- Ovine
- Ovis aries (Sheep)
- Rabbit
- Rainbow Trout
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- Human Cell
- In Vitro Cell Free System
- In vitro E. coli expression system
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Fc
- His
- Flag
- GST
- His (Fc)
- Avi
- hFc
- Myc
- human|IgG1|Fc
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Prlr Related Articles
- Prlr Related Research Area
Prlr involved in several pathways and played different roles in them. We selected most pathways Prlr participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prlr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | XCL1;CXCR1;IFNA2;CCR6;OSMR;TNFRSF6B;PRLR;VEGFAB;GH1 |
Neuroactive ligand-receptor interaction | P2RX4A;HRH4;GRIN2BB;PTGER1A;GNRHR2;NR3C1;PRLR;PTGER4B;CNR1 |
PIK-Akt signaling pathway | HGF;TCL1B4;COL6A6;ITGA10;PCK1;MDM2;ANGPT2;PRKCA;TNXB |
Jak-STAT signaling pathway | MTOR;IFNGR1;FHL1A;NT5C3;STAT1A;SOCS7;STAT4;IFNK;GH1 |
Prolactin signaling pathway | TNFSF11;STAT5A;INS;SHC2;MAPK1;MAPK13;INS2;ESR2;PIK3CB |
Prlr has several biochemical functions, for example, metal ion binding, ornithine decarboxylase activator activity, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prlr itself. We selected most functions Prlr had, and list some proteins which have the same functions with Prlr. You can find most of the proteins on our site.
Function | Related Protein |
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metal ion binding | PIKFYVE;DNAJA3A;ZNF831;KCNIP3A;COL9A1;ENPP4;LNX2A;OTUD7A;ANKMY2 |
ornithine decarboxylase activator activity | AZIN1;AZIN1A;PRLR;AZIN2;AZIN1B |
peptide hormone binding | GALR1;AGTR2;GIPR;CRHR2;AGTR1B;MC3R;GHR;ACVR1;GHRHR |
prolactin receptor activity | |
protein binding | RBM6;CSTF2T;LDLR;SRGAP3;CENPL;ARFGAP1;CHDH;INTS3;MT1F |
protein homodimerization activity | PYCARD;ASNS;ENPP1;BIRC5;S100B;TARBP2;HM13;SLC11A1;TRIM8 |
Prlr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prlr here. Most of them are supplied by our site. Hope this information will be useful for your research of Prlr.
GH1; NEK3; VAV2; YWHAZ
- Q&As
- Reviews
Q&As (5)
Ask a questionPRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.
Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.
The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).
PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.
Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.
Customer Reviews (3)
Write a reviewConsistent quality shines through—this protein has become indispensable.
This protein streamlines our experiments.
Fast shipping made this purchase convenient for our lab operations.
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