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Prlr

  • Official Full Name

    prolactin receptor

  • Overview

    This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
  • Synonyms

    PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; PRL-R; hPRL receptor; secreted prolactin binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Oryctolagus cuniculus (Rabbit)
  • Ovine
  • Ovis aries (Sheep)
  • Rabbit
  • Rainbow Trout
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • hFc
  • Myc
  • human|IgG1|Fc
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRLR-4144H Active Recombinant Human Prolactin Receptor Human N/A
Human PRLR-76H Recombinant Human Prolactin Receptor, chiMAX Fc Fusion Protein Insect Cell N/A
Human PRLR-2723HCL Recombinant Human PRLR HEK293T cell lysate HEK293T Myc/DDK
Human PRLR-59H Recombinant Human PRLR protein, GST-tagged Wheat Germ GST 1 a.a. - 622 a.a.
Human PRLR-177H Recombinant Human PRLR protein, His-tagged HEK293 His Met1-Asp234
Human PRLR-1677H Recombinant Human Prolactin Receptor, Fc-tagged Mammalian cells Fc
Human PRLR-58H Recombinant Human Prolactin Receptor, GST-tagged E.coli GST
Human PRLP-3704H Recombinant Human PRLP, GST-tagged E.coli GST
Human PRLR-2722HCL Recombinant Human PRLR cell lysate Human Cell N/A
Human PRLR-720H Recombinant Human PRLR Protein, His-tagged E.coli His Gln25~Asp234
Human PRLR-9071HFL Recombinant Full Length Human PRLR, Flag-tagged Mamanlian cells Flag
Human PRLR-2391H Recombinant Human PRLR Full Length Transmembrane protein, His&Myc-tagged In vitro E. coli expression system His&Myc 25-622aa
Human PRLR-2060H Recombinant Human PRLR protein, His-tagged HEK293 His Gln25-Asp234
Human PRLR-135H-B Recombinant Human PRLR Protein Pre-coupled Magnetic Beads HEK293
Human PRLR-386H Recombinant Human PRLR protein, Fc-tagged HEK293 human/IgG1/Fc 210
Human PRLR-605HF Recombinant Full Length Human PRLR Protein, GST-tagged In Vitro Cell Free System GST 622 amino acids
Human PRLR-135H Recombinant Human PRLR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRLR-2659H Active Recombinant Human PRLR protein, His-tagged HEK293 His Gln25-Asp234
Human PRLR-0638H Active Recombinant Human PRLR protein, Fc-tagged HEK293 Fc Gln25-Asp234
Mouse Prlr-7395M Recombinant Mouse Prlr, His tagged Human Cell His
Mouse Prlr-213M Recombinant Mouse Prlr protein, His&hFc-tagged HEK293 His&hFc Met1-Asp229
Mouse PRLR-1451MCL Recombinant Mouse PRLR cell lysate Human Cell N/A
Mouse PRLR-1247M Recombinant Mouse PRLR protein(Met1-Asp229), His-tagged HEK293 C-His Met1-Asp229
Mouse Prlr-5732M Recombinant Mouse Prlr Protein (Gln20-Asp229), C-Fc tagged Mammalian cells C-Fc Gln20-Asp229
Rat PRLR-4701R Recombinant Rat PRLR Protein Mammalian Cell His
Rat Prlr-7003R Recombinant Rat Prlr protein(Met1-Asp229), His-tagged HEK293 C-His Met1-Asp229
Rat Prlr-1797R Recombinant Rat Prolactin Receptor Mammalian cells N/A
Rat Prlr-62R Recombinant Rat Prolactin Receptor E.coli N/A
Rat Prlr -100R Recombinant Rat Prolactin Receptor, chiMAX Fc Fusion Protein Insect Cell N/A
Rat PRLR-1740RCL Recombinant Rat PRLR cell lysate Human Cell N/A
Rat Prlr-6389R-B Recombinant Rat Prlr Protein Pre-coupled Magnetic Beads HEK293
Rat Prlr-6389R Recombinant Rat Prlr Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Prlr-721R Recombinant Rat Prlr Protein, His-tagged E.coli His Gln20~Asp229
Rat PRLR-4360R-B Recombinant Rat PRLR Protein Pre-coupled Magnetic Beads HEK293
Rat PRLR-4360R Recombinant Rat PRLR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit PRLR-1837R Recombinant Rabbit Prolactin Soluble Receptor E.coli N/A
Bovine PRLR-53B Recombinant Bovine Prolactin Receptor E.coli N/A
Bovine PRLR-719B Recombinant Bovine PRLR Protein, His-tagged E.coli His Gln25~Asp234
Homo sapiens (Human) RFL18690HF Recombinant Full Length Human Prolactin Receptor(Prlr) Protein, His&Myc-Tagged E.coli expression system His&Myc Full Length of Mature Protein (25-622aa)
Oryctolagus cuniculus (Rabbit) RFL5507OF Recombinant Full Length Rabbit Prolactin Receptor(Prlr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-616)
Ovine PRLR-55O Recombinant Ovine Prolactin Receptor E.coli N/A
Ovis aries (Sheep) RFL24610OF Recombinant Full Length Sheep Prolactin Receptor(Prlr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-581)
Rainbow Trout prlr-61R Recombinant Rainbow Trout Prolactin Receptor E.coli N/A
Rattus norvegicus (Rat) RFL11347RF Recombinant Full Length Rat Prolactin Receptor(Prlr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-610)
Chicken PRLR-6417C Recombinant Chicken PRLR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Prlr Related Articles
  • Prlr Related Research Area

Prlr involved in several pathways and played different roles in them. We selected most pathways Prlr participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prlr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionXCL1;CXCR1;IFNA2;CCR6;OSMR;TNFRSF6B;PRLR;VEGFAB;GH1
Neuroactive ligand-receptor interactionP2RX4A;HRH4;GRIN2BB;PTGER1A;GNRHR2;NR3C1;PRLR;PTGER4B;CNR1
PIK-Akt signaling pathwayHGF;TCL1B4;COL6A6;ITGA10;PCK1;MDM2;ANGPT2;PRKCA;TNXB
Jak-STAT signaling pathwayMTOR;IFNGR1;FHL1A;NT5C3;STAT1A;SOCS7;STAT4;IFNK;GH1
Prolactin signaling pathwayTNFSF11;STAT5A;INS;SHC2;MAPK1;MAPK13;INS2;ESR2;PIK3CB

Prlr has several biochemical functions, for example, metal ion binding, ornithine decarboxylase activator activity, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prlr itself. We selected most functions Prlr had, and list some proteins which have the same functions with Prlr. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingPIKFYVE;DNAJA3A;ZNF831;KCNIP3A;COL9A1;ENPP4;LNX2A;OTUD7A;ANKMY2
ornithine decarboxylase activator activityAZIN1;AZIN1A;PRLR;AZIN2;AZIN1B
peptide hormone bindingGALR1;AGTR2;GIPR;CRHR2;AGTR1B;MC3R;GHR;ACVR1;GHRHR
prolactin receptor activity
protein bindingRBM6;CSTF2T;LDLR;SRGAP3;CENPL;ARFGAP1;CHDH;INTS3;MT1F
protein homodimerization activityPYCARD;ASNS;ENPP1;BIRC5;S100B;TARBP2;HM13;SLC11A1;TRIM8

Prlr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prlr here. Most of them are supplied by our site. Hope this information will be useful for your research of Prlr.

GH1; NEK3; VAV2; YWHAZ

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Sackmann-Sala, L; Goffin, V; et al. Prolactin-Induced Prostate Tumorigenesis. RECENT ADVANCES IN PROLACTIN RESEARCH 846:221-242(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does PRLR contribute to the development of breast cancer at the molecular level? 04/17/2022

PRLR overexpression or dysregulation has been associated with breast cancer. It can promote cell proliferation and survival through aberrant signaling pathways.

How does PRLR signaling vary in different tissues? 05/09/2021

Tissue-specific factors and the presence of co-receptors contribute to the diversity of PRLR signaling outcomes in different tissues and cell types.

What are the key signaling pathways activated by the PRLR protein? 02/22/2020

The JAK-STAT signaling pathway is a primary pathway activated by PRLR. It involves the activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STATs).

Explain the process of endocytosis and intracellular trafficking of PRLR. 01/01/2020

PRLR undergoes endocytosis upon ligand binding, and the internalized receptor-ligand complex is trafficked through intracellular compartments, influencing downstream signaling and receptor recycling.

Discuss the post-translational modifications involved in regulating PRLR activity. 11/28/2018

Phosphorylation is a crucial post-translational modification of PRLR, affecting its activation and downstream signaling. Other modifications, such as glycosylation, also play roles.

Customer Reviews (3)

Write a review
Reviews
04/03/2022

    Consistent quality shines through—this protein has become indispensable.

    02/24/2021

      This protein streamlines our experiments.

      12/22/2018

        Fast shipping made this purchase convenient for our lab operations.

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