rnps1
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  • Official Full Name
  • RNA binding protein S1, serine-rich domain
  • Background
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
  • Synonyms
  • RNPS1; RNA binding protein S1, serine-rich domain; E5.1; RNA-binding protein with serine-rich domain 1; SR protein; SR-related protein LDC2; RNA-binding protein S1, serine-rich domain;
Cat.#:RNPS1-179HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RNPS1 protein, T7-tagged
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Cat.#:RNPS1-2354HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RNPS1, GST-tagged
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Cat.#:RNPS1-14365MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNPS1 Protein
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Cat.#:RNPS1-5091RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RNPS1 Protein
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Cat.#:RNPS1-10150ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RNPS1
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Cat.#:RNPS1-2258HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNPS1 293 Cell Lysate
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Cat.#:RNPS1-2259HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNPS1 293 Cell Lysate
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Involved Pathway

RNPS1 involved in several pathways and played different roles in them. We selected most pathways RNPS1 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), which may be useful for your reference. Also, other proteins which involved in the same pathway with RNPS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region
CSTF1; U2AF2; NUDT21; LSM10; RNPS1; CSTF3; SRSF11; PAPOLA; CSTF2; ZFP473
Gene Expression
TSNAX; TET3; ZFP28; ZNF599; DGCR8; ZNF530; ZNF114; PTRF; MTA3; EIF2S1
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SMG8; SMG9; RNPS1
Nonsense-Mediated Decay (NMD)
RNPS1; SMG9; SMG8
Processing of Capped Intron-Containing Pre-mRNA
HNRNPA0A; SLBP; HNRNPA2B1; U2AF2; NUDT21; HNRPL; HNRNPH1L; CCAR1; HNRNPL2; PCBP2
RNA Polymerase II Transcription
GM3258; LSM11; SLBP; ZFP473; LSM10; PAPOLA; CSTF1; CCNT2B; U2AF2; ZNF473
RNA Polymerase II Transcription Termination
THOC4; CSTF3; CLP1; CSTF2; LSM10; ZFP473; LSM11; NUDT21; PAPOLA; SRSF11
RNA transport
NUP133; EIF3E; RPP14; EIF2B1; RPP25; NUP85; POM121L2; PHAX; NXF1; EEF1A2

Protein Function

RNPS1 has several biochemical functions, for example, NOT RNA binding, mRNA 3-UTR binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNPS1 itself. We selected most functions RNPS1 had, and list some proteins which have the same functions with RNPS1. You can find most of the proteins on our site.
Function
Related Protein
Function NOT RNA binding
Related Protein NCBP2; RNPS1
Function mRNA 3-UTR binding
Related Protein KHSRP; CPEB4; ELAVL4; ELAVL1; RIMS2; RNPS1; CPEB1A; CRYZ; RNF20; SERBP1
Function nucleotide binding
Related Protein AKT3A; SRSF7A; DAPK2A; PABPN1L; ZFML; RBM18; RAB35B; NXF2; TYMS; ABCB6
Function poly(A) RNA binding
Related Protein ZCCHC6; DDX55; RBM15B; RRP12; GANAB; MRPL4; CDK11B; HIST2H4A; HSP90AB1; SRSF7
Function protein binding
Related Protein NKG7; RNF180; PSMA5; MS4A12; CDC42EP2; FAM120B; ZNF148; SEC24D; ISYNA1; BCR

Interacting Protein

RNPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNPS1.
SRPK1; UPF3B; SART3; YWHAG; THRAP3; SRPK2; U2AF1; SRSF1