ST6GAL1
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Official Full Name
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
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Overview
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. -
Synonyms
ST6GAL1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; sialyltransferase 1 (beta galactoside alpha 2,6 sialytransferase) , SIAT1; beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1; B-cell antigen CD75; Alpha2,6-(N)-Sialyltransferase; Alpha2,6-NST; 2,6-Sialyltransferase; α2, 6-sialyltransferase (C); alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- His (Fc)
- Avi
- N/A
- N
- 6×His, GFP
- Involved Pathway
- Protein Function
- Interacting Protein
- ST6GAL1 Related Research Area
ST6GAL1 involved in several pathways and played different roles in them. We selected most pathways ST6GAL1 participated on our site, such as N-Glycan biosynthesis, Other types of O-glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ST6GAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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N-Glycan biosynthesis | ALG12;ALG5;MGAT5B;MGAT4C;ALG10;B4GALT1;MGAT5;DPM2;ALG9 |
Other types of O-glycan biosynthesis | LFNG;B3GALTLA;EOGT;RFNG;B4GALT2;ST6GAL2A;POMGNT1;ST6GAL1;MFNG |
Metabolic pathways | AADAT;UOX;NDUFB9;AGPAT3;NMRK2;HSD3B4;BHMT;TPI1;TDO2B |
ST6GAL1 has several biochemical functions, for example, beta-galactoside alpha-2,6-sialyltransferase activity, protein binding, sialyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST6GAL1 itself. We selected most functions ST6GAL1 had, and list some proteins which have the same functions with ST6GAL1. You can find most of the proteins on our site.
Function | Related Protein |
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beta-galactoside alpha-2,6-sialyltransferase activity | ST6GAL2B;ST6GAL2A;ST6GAL2;ST6GAL1 |
protein binding | SMAD3A;CTNNB2;SWSAP1;TMEM88;TDRD1;MITF;RNF170;F10;RNH1 |
sialyltransferase activity | ST6GALNAC1.2;ST6GAL2B;ST6GALNAC5B;ST6GALNAC1;ST6GALNAC5;ST3GAL2L;ST6GALNAC4;ST6GAL2A;ST6GAL1 |
ST6GAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST6GAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST6GAL1.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThis proteins regulate cell signaling by interacting with a variety of protein receptors, and the specific mechanism needs to be further studied.
The expression of ST6GAL1 proteins is affected by many factors, including cell differentiation, inflammation, viral infection, etc.
Involved in the insulin signaling pathway in diabetes, studies have shown that it can influence insulin signaling, which in turn affects blood sugar levels.
Plays an important role in a variety of biological processes, such as cell differentiation, glycoprotein modification, cell-cell interactions, etc.
ST6GAL1 plays an increasingly important role in cancer processes, regulating the invasion and metastasis of cancer cells, and studies have found that it is involved in many cancer processes.
ST6GAL1 proteins participate in the regulation of various cell signaling pathways, such as inflammatory signaling pathways, insulin signaling pathways, stem cell signaling pathways, etc.
Customer Reviews (3)
Write a reviewThis reproducibility of ST6GAL1 is very good, and it can maintain a high degree of consistent performance regardless of the conditions, making it ideal for experiments or applications that require a high degree of reproducibility.
Production process of ST6GAL1 focuses on resource recycling, reusing waste and reducing the consumption of natural resources.
The catalytic activity of this protein is very strong, it can perform excellent catalysis even under extremely harsh conditions, and its stability is impressive.
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