ascl1
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  • Official Full Name
  • achaete-scute family bHLH transcription factor 1
  • Background
  • This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ASCL1; achaete-scute family bHLH transcription factor 1; ASH1; HASH1; MASH1; bHLHa46; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46;
Cat.#:ASCL1-131HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ASCL1 protein, Arginine-tagged
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Cat.#:ASCL1-22HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human ASCL1 protein, His-tagged
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Cat.#:ASCL1-28522THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ASCL1
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Cat.#:ASCL1-901HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ASCL1 protein, GST-tagged
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Cat.#:ASCL1-2025MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ASCL1 Protein
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Cat.#:Ascl1-3064RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ascl1, His-tagged
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Cat.#:ASCL1-818RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ASCL1 Protein
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Cat.#:ASCL1-5982CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ASCL1
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Cat.#:ASCL1-8654HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ASCL1 293 Cell Lysate
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Involved Pathway

ASCL1 involved in several pathways and played different roles in them. We selected most pathways ASCL1 participated on our site, such as Delta-Notch Signaling Pathway, Neural Crest Differentiation, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Delta-Notch Signaling Pathway
SMAD3B; TCF3B; HEY2; ASCL1A; YY1; ZFPM1; HIVEP3; JAG1; YY1A; JAG2
Neural Crest Differentiation
CTBP2; PRTG; HEY2; OLIG1; TXLNB; ZIC1; LHX1; HOXA1; PHOX2B; OLIG2
Notch-mediated HES/HEY network
HES6; BGLAP; YY1; MYOD1; TLE1; ASCL1; GATA6; MYB; RCAN1; HEY1
SIDS Susceptibility Pathways
SNTA1; PHOX2A; DLX2; MECP2; FOXM1; CC2D1A; MAP2; KCNH2; POU2F2; MAZ

Protein Function

ASCL1 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL1 itself. We selected most functions ASCL1 had, and list some proteins which have the same functions with ASCL1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HMGXB4; STAT3; CREB1B; POU4F1; JUNBB; SMARCC1; NR4A2; SIX9; HMG20A; MGAA
Function E-box binding
Related Protein NEUROD2; BHLHE40; AHR; GATA3; TCF21; MYC; CLOCK; ASCL1; TAL1; ARNTL2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein FOXD1; ETV6; RBPJL; NR5A2; ONECUT2; ZNF100; HAND1; MYOG; ELK3; KDM6A
Function bHLH transcription factor binding
Related Protein ISL1; SOX9; USF2; FOXH1; RUNX2; LMO2; TCF3; TWIST1; IKZF4; EP300
Function chromatin binding
Related Protein MKRN1; CDCA5; CDC45; NOC2L; NSBP1; UBE2T; ORC1L; NFIA; ANKRD17; SMAD6
Function protein binding
Related Protein SLX1B; SID4; ADH1A; DNMBP; KLHL12; ZBTB49; FABP5; SETMAR; ST8SIA5; TRIM32
Function protein homodimerization activity
Related Protein GRPEL2; SLC14A2; DAPK3; CHMP4C; CADM3; XBP1; HMOX1; MID2; CRYBB2; TENM3
Function transcription factor activity, sequence-specific DNA binding
Related Protein SOX11B; SIX4; REST; ZNF571; CRX; HOXD4A; ZNF668; RXRAA; TBX1; ZNF493
Function transcription factor activity, transcription factor binding
Related Protein PER1; HIF1A; NEUROG1; LDB1B; LDB2B; TP63; LDB1A; PER2; ASCL1A; TRP63
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SP3; PROX1A; DLX4; HOXA2; TFAP2C; BACH1; ZKSCAN3; ZFPM1; PROX2; PROX1

Interacting Protein

ASCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL1.
TCF4; TCF3; dna-1

ASCL1 Related Articles

Karow, M; Schichor, C; et al. Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons. Jove-Journal of Visualized Experiments :-(2014).
Teicher, BA; et al. Targets in small cell lung cancer. BIOCHEMICAL PHARMACOLOGY 87:211-219(2014).