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Recombinant Human ASCL1 protein, His-tagged

Cat.No. : ASCL1-22H
Product Overview : Recombinant Human ASCL1, fused with N-His, was expressed in E. coli.
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Description : Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5"-CANNTG-3").
Source : E.coli
Species : Human
Tag : His
Form : 20mM Tris.Cl, 100mM NaCl, 50% Glycerol, pH8.0.
Molecular Mass : 27.4kDa(including fusion tag)
Protein length : 251aa(including fusion tag)
Applications : WB, ELISA, IP, antibody production, protein array
Storage : Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name : ASCL1 achaete-scute complex homolog 1 (Drosophila) [ Homo sapiens ]
Official Symbol : ASCL1
Synonyms : ASCL1; ASH1; bHLHa46; HASH1; ASH-1; MASH1;
Gene ID : 429
mRNA Refseq : NM_004316
Protein Refseq : NP_004307
MIM : 100790
UniProt ID : P50553
Chromosome Location : Delta-Notch Signaling Pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; SIDS Susceptibility Pathways, organism-specific biosystem;
Pathway : DNA binding; E-box binding; bHLH transcription factor binding; double-stranded DNA binding; protein binding; protein homodimerization activity; sequence-specific DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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Is ASCL1 associated with any human diseases? 07/21/2020

Yes, ASCL1 is associated with several human diseases, including neuroblastoma and small cell lung cancer, where it is often overexpressed and contributes to tumor development.

Is ASCL1 involved in neurogenesis? 12/13/2019

Yes, ASCL1 is a key regulator of neurogenesis. It acts as a transcription factor that directs the differentiation of neural stem cells into neurons during development.

Can ASCL1 promote cellular reprogramming? 07/24/2019

Yes, ASCL1, in combination with other transcription factors, can induce the reprogramming of somatic cells into neurons in vitro, demonstrating its ability to change cell fate.

Is ASCL1 important for the formation of specific neuronal subtypes? 05/22/2018

Yes, ASCL1 is critical for the formation of several neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.

Does ASCL1 have any role in non-neuronal tissues? 11/24/2017

Although ASCL1 is primarily associated with neural development, it is also expressed in specific regions of the developing lung, where it influences lung neuroendocrine cell differentiation.

Can ASCL1 be targeted for therapeutic interventions or drug discovery? 04/01/2017

ASCL1 is actively being researched as a potential therapeutic target in neuroblastoma and small cell lung cancer. Developing drugs that inhibit ASCL1 may help treat these diseases.

Does ASCL1 have a role in adult neurogenesis? 10/01/2016

While ASCL1's role in adult neurogenesis is not fully understood, studies suggest that it may play a role in the generation of newborn neurons in certain brain regions, such as the olfactory bulb.

What are the known interacting partners of ASCL1? 06/09/2016

ASCL1 interacts with various proteins involved in neural development and transcriptional regulation, including NEUROD1, TCF3, TLE1, and HDAC1.

Customer Reviews (3)

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Reviews
08/14/2022

    Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

    10/15/2019

      the manufacturer's support is crucial for researchers using ASCL1 protein in trials.

      02/22/2019

        They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ASCL1 protein in their studies.

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