cda
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  • Official Full Name
  • cytidine deaminase
  • Background
  • This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
  • Synonyms
  • CDA; cytidine deaminase; CDD; Cytidine aminohydrolase; EC 3.5.4.5; small cytidine deaminase; cytosine nucleoside deaminase
Cat.#:CDA-0894HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDA Protein, GST-Tagged
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Cat.#:CDA-598HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDA Protein, His-tagged
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Cat.#:CDA-206HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDA protein, T7/His-tagged
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Cat.#:CDA-26955THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDA, His-tagged
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Cat.#:CDA-317HCLTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human CDA Over-expression Lysate
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Cat.#:CDA-796HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cytidine Deaminase, His-tagged
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Cat.#:CDA-3925CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDA
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Cat.#:CDA-11703ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDA
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Involved Pathway

CDA involved in several pathways and played different roles in them. We selected most pathways CDA participated on our site, such as Pyrimidine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pyrimidine metabolism
POLR3A; UPRT; POLR3B; DCK; POLR2J2; AK9; POLE4; POLR2EB; ENTPD4; NT5E
Drug metabolism - other enzymes
CES1D; GUSB; UGT1A7; UGT1A2; Ces2e; CDA; ITPA; TK1; UGT1A6B; UGT1A4
Metabolic pathways
HYAL1; GALNT7; PLD3; CYP2P8; PLA2G12B; ST6GAL1; DLAT; HPSE2; PTDSS1A; MAN1A1

Protein Function

CDA has several biochemical functions, for example, cytidine deaminase activity, nucleoside binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDA itself. We selected most functions CDA had, and list some proteins which have the same functions with CDA. You can find most of the proteins on our site.
Function
Related Protein
Function cytidine deaminase activity
Related Protein APOBEC3G; APOBEC2; APOBEC3H; WBP2NL; AICDA; APOBEC3F; APOBEC1; CDA
Function nucleoside binding
Related Protein CDA; POLA1; PNP; AASS; ACTN4
Function protein binding
Related Protein PSMB1; RPS16; CCDC42; GFI1B; CPNE1; SH3BP1; PPP1R16A; SIAH2; PTEN; HAX1
Function protein homodimerization activity
Related Protein TIMM10; TRIM37; GYS2; PFKM; NR6A1; PYGB; NR0B1; ANG; ASNS; KCNH2
Function zinc ion binding
Related Protein PDLIM5B; DNLZ; KPNB1; RAI1; CA15C; RNF126; LHX2B; TRIM2; MICALL1; KAT7A

Interacting Protein

CDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDA here. Most of them are supplied by our site. Hope this information will be useful for your research of CDA.
SDCBP; ZBTB24; PSMA1; PTGER3; LNX1; PLEKHB2; WDYHV1

CDA Related Articles

Jansen, MA; Tromp, IIM; et al. Infant feeding and anti-tissue transglutaminase antibody concentrations in the Generation R Study. AMERICAN JOURNAL OF CLINICAL NUTRITION 100:1095-1101(2014).
Topp, ZZ; Saven, A; et al. Hairy cell leukemia: a 'hair-raising' update. EXPERT REVIEW OF HEMATOLOGY 7:659-669(2014).