guk1
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  • Official Full Name
  • guanylate kinase 1
  • Background
  • The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • GUK1; guanylate kinase 1; guanylate kinase; GMK; GMP kinase; KGUA_HUMAN; OTTHUMP00000037504; OTTHUMP00000037738; OTTHUMP00000037739; OTTHUMP00000037741; OTTHUMP00000037742; OTTHUMP00000037743; OTTHUMP00000037745; OTTHUMP00000037746; OTTHUMP00000037747; OTTHUMP00000037748; OTTHUMP00000037750; OTTHUMP00000037751
Cat.#:GUK1-4495HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GUK1 Protein, GST-tagged
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Cat.#:GUK1-13623HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUK1, GST-tagged
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Cat.#:GUK1-185HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUK1 protein, His-tagged
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Cat.#:GUK1-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUK1 protein, His-tagged (Bioactivity Validated)
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Cat.#:GUK1-2785HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Guanylate Kinase 1, His-tagged
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Cat.#:GUK1-29176THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GUK1, His-tagged
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Cat.#:GUK1-2020RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GUK1 Protein, His-tagged
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Cat.#:GUK1-5674HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GUK1 293 Cell Lysate
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Involved Pathway

GUK1 involved in several pathways and played different roles in them. We selected most pathways GUK1 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
NT5C2B; NTPCR; PRPS1; PDE4C; NT5C3A; AMPD3B; GUK1A; PNP; NT5M; PKMA
Metabolic pathways
G6PCA.2; UQCRC2A; PFKL; GALNT18; PYCR2; PLA2G10; CELL; ALG14; FUT6; GPIA

Protein Function

GUK1 has several biochemical functions, for example, ATP binding, guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUK1 itself. We selected most functions GUK1 had, and list some proteins which have the same functions with GUK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein JAK2; DDX58; UBE2L3B; MERTK; LRGUK; RPS6KB1; TK2; PRKY; PINK1; MYHC4
Function guanylate kinase activity
Related Protein GUK1A; DLG4; TJP2; CASK; GUK1B; MPP3; MPP2; MPP1; DLG2; DLG4B

Interacting Protein

GUK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUK1.
UBE2Z; IQCB1

GUK1 Related Articles

Wang-Rosenke, Y; Khadzhynov, D; et al. Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat. BMC NEPHROLOGY 14:-(2013).
Ito, H; Morishita, R; et al. Biochemical and morphological characterization of MAGI-1 in neuronal tissue. JOURNAL OF NEUROSCIENCE RESEARCH 90:1776-1781(2012).