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GUK1

  • Official Full Name

    guanylate kinase 1

  • Overview

    The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GUK1; guanylate kinase 1; guanylate kinase; GMK; GMP kinase; KGUA_HUMAN; OTTHUMP00000037504; OTTHUMP00000037738; OTTHUMP00000037739; OTTHUMP00000037741; OTTHUMP00000037742; OTTHUMP00000037743; OTTHUMP00000037745; OTTHUMP00000037746; OTTHUMP00000037747; OTTHUMP00000037748; OTTHUMP00000037750; OTTHUMP00000037751;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GUK1-19H Active Recombinant Human GUK1 protein, His-tagged (Bioactivity Validated) E.coli His
Human GUK1-185H Active Recombinant Human GUK1 protein, His-tagged E.coli His
Human GUK1-2785H Recombinant Human Guanylate Kinase 1, His-tagged E.coli His
Human GUK1-13623H Recombinant Human GUK1, GST-tagged E.coli GST 1-197a.a.
Human GUK1-4495H Recombinant Human GUK1 Protein, GST-tagged Wheat Germ GST
Human GUK1-29176TH Recombinant Human GUK1, His-tagged E.coli His 197 amino acids
Human GUK1-5674HCL Recombinant Human GUK1 293 Cell Lysate HEK293 N/A
Human GUK1-4406H Recombinant Human GUK1 protein, His-SUMO-tagged E.coli His-SUMO 2-197aa
Human GUK1-3952H Recombinant Human GUK1 protein, His-tagged E.coli His 1-197 aa
Human GUK1-5223H Recombinant Human GUK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GUK1-31H Recombinant Human GUK1 Protein (AA 1-198), N-His-Tagged HEK293 N-His AA 1-198
Human GUK1-3348HF Recombinant Full Length Human GUK1 Protein, GST-tagged In Vitro Cell Free System GST 197 amino acids
Mouse Guk1-1080M Recombinant Mouse Guk1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque GUK1-2020R Recombinant Rhesus monkey GUK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GUK1-1841R-B Recombinant Rhesus Macaque GUK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GUK1-1841R Recombinant Rhesus Macaque GUK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GUK1 Related Articles

GUK1 involved in several pathways and played different roles in them. We selected most pathways GUK1 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismADSS;ENPP3;POLR3GL;ADKA;PRUNE;POLR3E;GDA;ADK;POLR2J
Metabolic pathwaysNDUFA10;COX15;SDSL;GALC;FAH;NDUFS8;CYP17A1;PAPSS2;MTHFR

GUK1 has several biochemical functions, for example, ATP binding, guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUK1 itself. We selected most functions GUK1 had, and list some proteins which have the same functions with GUK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP1A3A;MOV10B.1;P2RX8;MYO7A;HLCS;MAPK3;CLK4;FUK;SGK2A
guanylate kinase activityGUK1A;TJP2;CASK;DLG1L;MPP2;DLG3;GUK1;CARD11;MPP3

GUK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUK1.

UBE2Z; IQCB1

Wang-Rosenke, Y; Khadzhynov, D; et al. Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat. BMC NEPHROLOGY 14:-(2013).
Ito, H; Morishita, R; et al. Biochemical and morphological characterization of MAGI-1 in neuronal tissue. JOURNAL OF NEUROSCIENCE RESEARCH 90:1776-1781(2012).
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