JUP
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Official Full Name
junction plakoglobin
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Overview
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. -
Synonyms
JUP; junction plakoglobin; catenin (cadherin associated protein), gamma 80kDa , CTNNG; DP3; DPIII; PDGB; PKGB; catenin gamma; desmoplakin-3; gamma-catenin; desmoplakin III; catenin (cadherin-associated protein), gamma 80kDa; catenin (cadherin-associated p;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
JUP involved in several pathways and played different roles in them. We selected most pathways JUP participated on our site, such as Acute myeloid leukemia, Adherens junctions interactions, Arf6 trafficking events, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | TCF7;RARA;FLT3;ARAF;RPS6KB2;PIK3R3;IKBKG;KRAS;PIK3CB |
| Adherens junctions interactions | CADM2;PVRL2L;CTNNB1;CDH10A;CDH18A;CDH6;CDH17;PVRL1A;JUPA |
| Arf6 trafficking events | EXOC5;CTNNA1;EXOC6;CTNND1;DNM2;CLTC;PTBP3;CPE;JUP |
| Arrhythmogenic right ventricular cardiomyopathy | CDH2;CACNG2;CTNNA2;JUP;CACNG3;DSC2;CTNNA1;DMD;DSP |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTB;ITGA5;TCF7L2;GJA1;AASS;DMD;CTNNA1;ITGA7;CTNNA2 |
| Cell junction organization | COL17A1;PLEC;DST;INADL;CDH18A;CLDN4;CDH5;CDH4;CDH6 |
| Cell-Cell communication | PVRL2L;CDH12A;SPTBN1;TESK1;CADM2B;CDH10A;CLDN23;CLDN3;KIRRELB |
| Cell-cell junction organization | CLDN20;ANG;CLDN7;CLDN3;CDH8;CADM2A;CDH9;CDH7;CDH17 |
JUP has several biochemical functions, for example, alpha-catenin binding, cadherin binding, cell adhesion molecule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUP itself. We selected most functions JUP had, and list some proteins which have the same functions with JUP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-catenin binding | VCL;JUPA;CTNNB1;CDH24;CDH2;PKP2;NUMB;PKP3;AJUBA |
| cadherin binding | FER;CTNNA3;GNA13A;FXYD5;NUMB;TRPC4;CTNNAL1;OLFM4;Fert2 |
| cell adhesion molecule binding | CADM1B;CD1d1;CAML;ITGB2;PVR;CADM2A;ITGB3;NLGN4X;FGFR1 |
| cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | DSP;PKP2;DSC2;DSG2;JUP;CTNNA3 |
| NOT nuclear hormone receptor binding | JUP;JUPA |
| protein binding | MED30;GATSL3;MTM1;PRICKLE1A;CHPF;ABCG1;KRTAP13-3;C11orf68;TBC1D20 |
| protein homodimerization activity | CCL5;ADRB3;CDH13;TRPM8;RABEP1;EEA1;SDS;PAFAH1B1;SETMAR |
| protein phosphatase binding | DRD1;AP3B1;TRAF2;ROS1;TRP53;CDH2;DRD1A;VCP;PPP1R3G |
| signal transducer activity | PLCH2;GNG7;ERG;PTK2AB;PLCD4;TAAR14J;RHOL;GNG11;GNG4 |
| structural constituent of cell wall | JUP;RTN4B |
| structural molecule activity | CYT1;KRT6A;CLDN11A;CLDN9;KRT81;NGS;MAP7D2A;CLDNH;KRT73 |
| transcription coactivator activity | TAF11;TUBB3;MED31;TRIM24;LPIN2;CREBBP;TAF12;MMS19;PARK7 |
JUP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUP here. Most of them are supplied by our site. Hope this information will be useful for your research of JUP.
APC; PSEN1; WDYHV1; PECAM1; TCF7L2
Research Area
Related articles
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in JUP can lead to skin and heart diseases due to compromised cell adhesion.
Altered JUP expression is linked to cancer, affecting cell adhesion and migration.
Therapeutic strategies may involve modulating JUP function to restore normal cell adhesion.
JUP is crucial for maintaining cell-cell adhesion and tissue integrity.
JUP is predominantly expressed in epithelial and cardiac tissues.
It maintains epithelial integrity, ensuring proper tissue function and barrier formation.
It anchors intermediate filaments to desmosomes, stabilizing cell adhesion.
Customer Reviews (3)
Write a reviewGreat for protein analysis.
Worked well, satisfied customer.
Speedy delivery, product intact.
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