Recombinant Human JUP protein, GST-tagged

• Cat.No.: JUP-301494H
• Product Overview: Recombinant Human JUP (669-745 aa) protein, fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization.
• Protein length: Thr669-Ala745
• AA Sequence: TNSLFKHDPAAWEAAQSMIPINEPY GDDMDATYRPMYSSDVPLDPLEMHM DMDGDYPIDTYSDGLRPPYPTADHM LA
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Stability: Store for up to 12 months at -20°C to -80°C as lyophilized powder.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.

Gene Information

• Gene Name: JUP junction plakoglobin [ Homo sapiens ]
• Official Symbol: JUP
• Synonyms: JUP; junction plakoglobin; catenin (cadherin associated protein), gamma 80kDa , CTNNG; DP3; DPIII; PDGB; PKGB; catenin gamma; desmoplakin-3; gamma-catenin; desmoplakin III; catenin (cadherin-associated protein), gamma 80kDa; catenin (cadherin-associated protein), gamma (80kD); CTNNG; ARVD12
• Gene ID: 3728
• mRNA Refseq: NM_002230
• Protein Refseq: NP_002221
• MIM: 173325
• UniProt ID: P14923

Reviews

07/27/2022

Great for protein analysis.

09/10/2021

Worked well, satisfied customer.

01/12/2021

Speedy delivery, product intact.

Q&As

What are the genetic implications of mutations in the JUP gene?

Mutations in JUP can lead to skin and heart diseases due to compromised cell adhesion.

How is JUP implicated in cancer development and progression?

Altered JUP expression is linked to cancer, affecting cell adhesion and migration.

Are there potential therapeutic strategies targeting JUP?

Therapeutic strategies may involve modulating JUP function to restore normal cell adhesion.

What is the primary biological function of JUP?

JUP is crucial for maintaining cell-cell adhesion and tissue integrity.

In which tissues is JUP predominantly expressed?

JUP is predominantly expressed in epithelial and cardiac tissues.

What role does JUP play in maintaining epithelial integrity?

It maintains epithelial integrity, ensuring proper tissue function and barrier formation.

How does JUP contribute to cell-cell adhesion?

It anchors intermediate filaments to desmosomes, stabilizing cell adhesion.