Recombinant Human JUP Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: JUP-1438H
• Product Overview: JUP MS Standard C13 and N15-labeled recombinant protein (NP_002221) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 81.7 kDa
• AA Sequence: MEVMNLMEQPIKVTEWQQTYTYDSG IHSGANTCVPSVSSKGIMEEDEACG RQYTLKKTTTYTQGVPPSQGDLEYQ MSTTARAKRVREAMCPGVSGEDSSL LLATQVEGQATNLQRLAEPSQLLKS AIVHLINYQDDAELATRALPELTKL LNDEDPVVVTKAAMIVNQLSKKEAS RRALMGSPQLVAAVVRTMQNTSDLD TARCTTSILHNLSHHREGLLAIFKS GGIPALVRMLSSPVESVLFYAITTL HNLLLYQEGAKMAVRLADGLQKMVP LLNKNNPKFLAITTDCLQLLAYGNQ ESKLIILANGGPQALVQIMRNYSYE KLLWTTSRVLKVLSVCPSNKPAIVE AGGMQALGKHLTSNSPRLVQNCLWT LRNLSDVATKQEGLESVLKILVNQL SVDDVNVLTCATGTLSNLTCNNSKN KTLVTQNSGVEALIHAILRAGDKDD ITEPAVCALRHLTSRHPEAEMAQNS VRLNYGIPAIVKLLNQPNQWPLVKA TIGLIRNLALCPANHAPLQEAAVIP RLVQLLVKAHQDAQRHVAAGTQQPY TDGVRMEEIVEGCTGALHILARDPM NRMEIFRLNTIPLFVQLLYSSVENI QRVAAGVLCELAQDKEAADAIDAEG ASAPLMELLHSRNEGTATYAAAVLF RISEDKNPDYRKRVSVELTNSLFKH DPAAWEAAQSMIPINEPYGDDLDAT YRPMYSSDVPLDPLEMHMDMDGDYP IDTYSDGLRPPYPTADHMLATRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: JUP junction plakoglobin [ Homo sapiens (human) ]
• Official Symbol: JUP
• Synonyms: JUP; junction plakoglobin; catenin (cadherin associated protein), gamma 80kDa, CTNNG; DP3; DPIII; PDGB; PKGB; catenin gamma; desmoplakin-3; gamma-catenin; desmoplakin III; catenin (cadherin-associated protein), gamma 80kDa; catenin (cadherin-associated protein), gamma (80kD); CTNNG; ARVD12
• Gene ID: 3728
• mRNA Refseq: NM_002230
• Protein Refseq: NP_002221
• MIM: 173325
• UniProt ID: P14923

Reviews

07/27/2022

Great for protein analysis.

09/10/2021

Worked well, satisfied customer.

01/12/2021

Speedy delivery, product intact.

Q&As

What are the genetic implications of mutations in the JUP gene?

Mutations in JUP can lead to skin and heart diseases due to compromised cell adhesion.

How is JUP implicated in cancer development and progression?

Altered JUP expression is linked to cancer, affecting cell adhesion and migration.

Are there potential therapeutic strategies targeting JUP?

Therapeutic strategies may involve modulating JUP function to restore normal cell adhesion.

What is the primary biological function of JUP?

JUP is crucial for maintaining cell-cell adhesion and tissue integrity.

In which tissues is JUP predominantly expressed?

JUP is predominantly expressed in epithelial and cardiac tissues.

What role does JUP play in maintaining epithelial integrity?

It maintains epithelial integrity, ensuring proper tissue function and barrier formation.

How does JUP contribute to cell-cell adhesion?

It anchors intermediate filaments to desmosomes, stabilizing cell adhesion.