Active Recombinant Full Length Human JUP Protein, C-Flag-tagged

• Cat.No.: JUP-295HFL
• Product Overview: Recombinant Full Length Human JUP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Surface Plasmon Ressonance (SPR)
• Molecular Mass: 81.6 kDa
• AA Sequence: MEVMNLMEQPIKVTEWQQTYTYDSG IHSGANTCVPSVSSKGIMEEDEACG RQYTLKKTTTYTQGVPPSQG DLEYQMSTTARAKRVREAMCPGVSG EDSSLLLATQVEGQATNLQRLAEPS QLLKSAIVHLINYQDDAELA TRALPELTKLLNDEDPVVVTKAAMI VNQLSKKEASRRALMGSPQLVAAVV RTMQNTSDLDTARCTTSILH NLSHHREGLLAIFKSGGIPALVRML SSPVESVLFYAITTLHNLLLYQEGA KMAVRLADGLQKMVPLLNKN NPKFLAITTDCLQLLAYGNQESKLI ILANGGPQALVQIMRNYSYEKLLWT TSRVLKVLSVCPSNKPAIVE AGGMQALGKHLTSNSPRLVQNCLWT LRNLSDVATKQEGLESVLKILVNQL SVDDVNVLTCATGTLSNLTC NNSKNKTLVTQNSGVEALIHAILRA GDKDDITEPAVCALRHLTSRHPEAE MAQNSVRLNYGIPAIVKLLN QPNQWPLVKATIGLIRNLALCPANH APLQEAAVIPRLVQLLVKAHQDAQR HVAAGTQQPYTDGVRMEEIV EGCTGALHILARDPMNRMEIFRLNT IPLFVQLLYSSVENIQRVAAGVLCE LAQDKEAADAIDAEGASAPL MELLHSRNEGTATYAAAVLFRISED KNPDYRKRVSVELTNSLFKHDPAAW EAAQSMIPINEPYGDDLDAT
  YRPMYSSDVPLDPLEMHMDMDGDYP IDTYSDGLRPPYPTADHMLATRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

Gene Information

• Gene Name: JUP junction plakoglobin [ Homo sapiens (human) ]
• Official Symbol: JUP
• Synonyms: PG; DP3; PDGB; PKGB; CTNNG; DPIII
• Gene ID: 3728
• mRNA Refseq: NM_002230.4
• Protein Refseq: NP_002221.1
• MIM: 173325
• UniProt ID: P14923

Reviews

07/27/2022

Great for protein analysis.

09/10/2021

Worked well, satisfied customer.

01/12/2021

Speedy delivery, product intact.

Q&As

What are the genetic implications of mutations in the JUP gene?

Mutations in JUP can lead to skin and heart diseases due to compromised cell adhesion.

How is JUP implicated in cancer development and progression?

Altered JUP expression is linked to cancer, affecting cell adhesion and migration.

Are there potential therapeutic strategies targeting JUP?

Therapeutic strategies may involve modulating JUP function to restore normal cell adhesion.

What is the primary biological function of JUP?

JUP is crucial for maintaining cell-cell adhesion and tissue integrity.

In which tissues is JUP predominantly expressed?

JUP is predominantly expressed in epithelial and cardiac tissues.

What role does JUP play in maintaining epithelial integrity?

It maintains epithelial integrity, ensuring proper tissue function and barrier formation.

How does JUP contribute to cell-cell adhesion?

It anchors intermediate filaments to desmosomes, stabilizing cell adhesion.