yars
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  • Official Full Name
  • tyrosyl-tRNA synthetase
  • Background
  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
  • Synonyms
  • YARS; tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; tyrosine tRNA ligase 1; cytoplasmic; tyrRS; YRS; YTS; CMTDIC; SYYC_HUMAN; Tyrosyl tRNA synthetase; Tyrosyl--tRNA ligase; OTTHUMP00000004027; tyrosine tRNA ligase 1, cytoplasmic
Cat.#:YARS-207HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS protein, T7/His-tagged
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Cat.#:YARS-230HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS protein, T7/His-tagged
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Cat.#:YARS-31445THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS, His-tagged
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Cat.#:YARS-31446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS, His-tagged
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Cat.#:YARS-8216HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS protein, His & T7-tagged
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Cat.#:YARS-991HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YARS protein, His-tagged
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Cat.#:YARS-18649MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YARS Protein
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Cat.#:YARS-6623RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YARS Protein
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Cat.#:YARS-1459CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YARS
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Cat.#:YARS-11463ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish YARS
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Cat.#:YARS-249HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YARS 293 Cell Lysate
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Involved Pathway

YARS involved in several pathways and played different roles in them. We selected most pathways YARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with YARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
GATC; EPRS; VARS; GATB; PET112L; MARS; HARS; SARS2; DARS2; WARS

Protein Function

YARS has several biochemical functions, for example, ATP binding, interleukin-8 receptor binding, NOT isoleucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by YARS itself. We selected most functions YARS had, and list some proteins which have the same functions with YARS. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein P2RX7; FANCM; DHX30; DGUOK; JAK2B; UBA2; UBE2L3; RPS6KC1; MYH9; UBE2G1A
Function interleukin-8 receptor binding
Related Protein YARS; IL-8; MADD
Function NOT isoleucine-tRNA ligase activity
Related Protein YARS; MADD
Function poly(A) RNA binding
Related Protein SNIP1; NCBP1; TBL2; ACTN4; ILF3; APOBEC3F; MTERF; S100A4; CDK5R2; PRPF40A
Function signal transducer activity
Related Protein OLFR1440; LSP1; STAT6; OLFR151; PLCD1; NEK6; LITAF; GNAO1; TAAR8C; TNK1
Function tRNA binding
Related Protein MARS; CTU1; TRMT1L; DARS2; IFIT5; YARS2; MADD; ALKBH8; PTCD1; NSUN2
Function tyrosine-tRNA ligase activity
Related Protein YARS2; MADD; YARS

Interacting Protein

YARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YARS here. Most of them are supplied by our site. Hope this information will be useful for your research of YARS.
SAP18; EIF1B; EIF6; GABARAPL2; ARF6; IKBKE; FTSJ1; TRAF6; VCAM1; Wdr5; PPP2R2A; Map3k12; Mib1; Sidt2; Pxdc1; SORT1