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HARS

  • Official Full Name

    histidyl-tRNA synthetase

  • Overview

    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
  • Synonyms

    HARS; histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic; histidine tRNA ligase 1; cytoplasmic; EC 6.1.1.21; FLJ20491; HisRS; histidine translase; Histidine tRNA ligase; Histidyl tRNA synthetase; HRS; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; OTTHUMP00000159884; OTTHUMP00000223659; OTTHUMP00000223661; OTTHUMP00000223662; OTTHUMP00000223663; OTTHUMP00000223664; OTTHUMP00000224325; histidine-tRNA ligase; histidine--tRNA ligase; histidine tRN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • Baculovirus-Insect Cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HARS-46H Recombinant Human Histidyl-tRNA synthetase E.coli N/A
Human HARS-13669H Recombinant Human HARS, GST-tagged E.coli GST 1-282a.a.
Human HARS-793H Recombinant Human Histidyl-tRNA Synthetase, His-tagged E.coli His
Human HARS-29181TH Recombinant Human HARS, His-tagged E.coli His 509 amino acids
Human HARS-8209H Recombinant Human HARS protein, His-tagged E.coli His Met1~Gln294
Human HARS-369H Recombinant Human Histidyl-tRNA Synthetase, His-tagged Sf9 Insect Cell His
Human HARS-4580H Recombinant Human HARS Protein, GST-tagged Wheat Germ GST
Human HARS-770HCL Recombinant Human HARS cell lysate N/A
Human HARS-370H Recombinant Human HARS protein (Ala2-Cys509), His-tagged Baculovirus-Insect Cells His
Human HARS-2229H Recombinant Human HARS protein, His-tagged Insect Cell His 2-504aa
Human HARS-3449H Recombinant Human HARS protein, His-tagged E.coli His 1-282 aa
Human HARS-2231H Recombinant Human HARS protein, His-tagged Insect Cells His Ala2-Cys509
Human HARS-3412HF Recombinant Full Length Human HARS Protein, GST-tagged In Vitro Cell Free System GST 509 amino acids
Mouse HARS-7483M Recombinant Mouse HARS Protein Mammalian Cell His
Mouse HARS-4058M-B Recombinant Mouse HARS Protein Pre-coupled Magnetic Beads HEK293
Mouse HARS-4058M Recombinant Mouse HARS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HARS-8500Z Recombinant Zebrafish HARS Mammalian Cell His
Chicken HARS-1296C Recombinant Chicken HARS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HARS involved in several pathways and played different roles in them. We selected most pathways HARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisPSTK;RARS;PARS2;NARS;YARS;KARS;NARS2;MARS2;AARS

HARS has several biochemical functions, for example, ATP binding, histidine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HARS itself. We selected most functions HARS had, and list some proteins which have the same functions with HARS. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCKMT1B;SRPK1B;FYN;INSRA;EP400;HELLS;FYNA;GTF2F2A;TSSK4
histidine-tRNA ligase activityHARS2;HARS

HARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HARS here. Most of them are supplied by our site. Hope this information will be useful for your research of HARS.

TRAF6; TNIK; 15-deoxy-delta(12,14; ssrna_ug; NEDD8

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