hars
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  • Official Full Name
  • histidyl-tRNA synthetase
  • Background
  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
  • Synonyms
  • HARS; histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic; histidine tRNA ligase 1; cytoplasmic; EC 6.1.1.21; FLJ20491; HisRS; histidine translase; Histidine tRNA ligase; Histidyl tRNA synthetase; HRS; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; OTTHUMP00000159884; OTTHUMP00000223659; OTTHUMP00000223661; OTTHUMP00000223662; OTTHUMP00000223663; OTTHUMP00000223664; OTTHUMP00000224325; histidine-tRNA ligase; histidine--tRNA ligase; histidine tRN
Cat.#:HARS-4580HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HARS Protein, GST-tagged
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Cat.#:HARS-369HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Histidyl-tRNA Synthetase, His-tagged
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Cat.#:HARS-46HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histidyl-tRNA synthetase
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Cat.#:HARS-13669HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HARS, GST-tagged
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Cat.#:HARS-29181THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HARS, His-tagged
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Cat.#:HARS-793HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Histidyl-tRNA Synthetase, His-tagged
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Cat.#:HARS-8209HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HARS protein, His-tagged
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Cat.#:HARS-8327HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HARS, His tagged
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Cat.#:HARS-7483MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HARS Protein
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Cat.#:HARS-1296CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HARS
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Cat.#:HARS-8500ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HARS
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Cat.#:HARS-770HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HARS cell lysate
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Involved Pathway

HARS involved in several pathways and played different roles in them. We selected most pathways HARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
HARS2; WARS; HARS; SARS; EPRS; PSTK; GATC; QRSL1; YARS2; SEPSECS

Protein Function

HARS has several biochemical functions, for example, ATP binding, histidine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HARS itself. We selected most functions HARS had, and list some proteins which have the same functions with HARS. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein GSK3A; STK32B; PAK2B; DYNC2H1; PIK3C2G; SMYHC3; MAPKAPK2; MYO1G; ACTR1B; MYO1H
Function histidine-tRNA ligase activity
Related Protein HARS2; HARS

Interacting Protein

HARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HARS here. Most of them are supplied by our site. Hope this information will be useful for your research of HARS.
TRAF6; TNIK; 15-deoxy-delta(12,14; ssrna_ug; NEDD8