inpp5a
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  • Official Full Name
  • inositol polyphosphate-5-phosphatase, 40kDa
  • Background
  • The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
  • Synonyms
  • INPP5A; inositol polyphosphate-5-phosphatase, 40kDa; inositol polyphosphate 5 phosphatase, 40kD; type I inositol-1,4,5-trisphosphate 5-phosphatase; 5PTASE; 43 kDa inositol polyphosphate 5 phophatase; CTCL tumor antigen HD CL 02; inositol polyphosphate 5 phophatase; 40kDa; InsP3 5 phosphatase; type I inositol 1; 4; 5 trisphosphate 5 phosphatase; 43 kDa inositol polyphosphate 5-phophatase; 5-trisphosphate 5-phosphatase; CTCL tumor antigen HD-CL-02; DKFZp434A1721; I5P1; I5P1_HUMAN; Inositol polyphosphate 5 phosphatase; inositol polyphosphate-5-phosphatase A; inositol trisphosphate-5-phosphatase; INPP5A inositol polyphosphate-5-phosphatase; InsP3 5-phosphatase; MGC116947; MGC116949; Type I inositol-1; type I inositol-1,4,5-trisphosphate 5-phophatase; OTTHUMP00000020775; OTTHUMP00000020776; OTTHUMP00000020777; inositol trisphosphate-5-phosphatase, 40kD; type I inosito
Cat.#:INPP5A-1012HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INPP5A Protein (1-409 aa), His-SUMO-tagged
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Cat.#:INPP5A-5108HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INPP5A Protein, GST-tagged
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Cat.#:INPP5A-27622THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human INPP5A
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Cat.#:INPP5A-5199HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP5A 293 Cell Lysate
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Involved Pathway

INPP5A involved in several pathways and played different roles in them. We selected most pathways INPP5A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
ITPK1A; PIP4K2C; PIK3C2B; INPP5KA; PI4KA; SYNJ2; MINPP1B; ISYNA1; MIOX; PLCG1
Metabolic pathways
MAN1A2; Aldh1a7; POLR2I; PLCG2; POLR2J3; NT5C2A; P4HA2; B3GNT6; G6PD; ADKB
Phosphatidylinositol signaling system
PIKFYVE; MTM1; PIK3CG; INPP4AB; IMPA1; PIK3CA; PIP4K2A; INPP5K; PIK3R3A; IMPA2

Protein Function

INPP5A has several biochemical functions, for example, PH domain binding, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5A itself. We selected most functions INPP5A had, and list some proteins which have the same functions with INPP5A. You can find most of the proteins on our site.
Function
Related Protein
Function PH domain binding
Related Protein EPHA4; INPP5A; EPB41L2
Function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Related Protein INPP5K; INPP5J; INPP5A
Function inositol-1,4,5-trisphosphate 5-phosphatase activity
Related Protein INPP5J; INPP5K; INPP5A; INPP5B
Function inositol-polyphosphate 5-phosphatase activity
Related Protein INPP5K; INPP5D; INPP5A; INPP5J; INPPL1; INPP5E
Function protein binding
Related Protein CAND1; PRRC1; MKNK1; SYT11; CCDC137; EXOC8; MRPS6; TOMM70A; UHRF1; TUBB2A

Interacting Protein

INPP5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5A here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5A.
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INPP5A Related Articles

Milinkovic, V; Bankovic, J; et al. Identification of Novel Genetic Alterations in Samples of Malignant Glioma Patients. PLOS ONE 8:-(2013).
Kasumu, AW; Liang, X; et al. Chronic Suppression of Inositol 1,4,5-Triphosphate Receptor-Mediated Calcium Signaling in Cerebellar Purkinje Cells Alleviates Pathological Phenotype in Spinocerebellar Ataxia 2 Mice. JOURNAL OF NEUROSCIENCE 32:12786-12796(2012).