Recombinant Human INPP5A Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: INPP5A-3623H
• Product Overview: INPP5A MS Standard C13 and N15-labeled recombinant protein (NP_005530) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 47.8 kDa
• AA Sequence: MAGKAAAPGTAVLLVTANVGSLFDD PENLQKNWLREFYQVVHTHKPHFMA LHCQEFGGKNYEASMSHVDKFVKEL LSSDAMKEYNRARVYLDENYKSQEH FTALGSFYFLHESLKNIYQFDFKAK KYRKVAGKEIYSDTLESTPMLEKEK FPQDYFPECKWSRKGFIRTRWCIAD CAFDLVNIHLFHDASNLVAWETSPS VYSGIRHKALGYVLDRIIDQRFEKV SYFVFGDFNFRLDSKSVVETLCTKA TMQTVRAADTNEVVKLIFRESDNDR KVMLQLEKKLFDYFNQEVFRDNNGT ALLEFDKELSVFKDRLYELDISFPP SYPYSEDARQGEQYMNTRCPAWCDR ILMSPSAKELVLRSESEEKVVTYDH IGPNVCMGDHKPVFLAFRIMPGAGK PHAHVHKCCVVQTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: INPP5A inositol polyphosphate-5-phosphatase A [ Homo sapiens (human) ]
• Official Symbol: INPP5A
• Synonyms: INPP5A; inositol polyphosphate-5-phosphatase, 40kDa; inositol polyphosphate 5 phosphatase, 40kD; type I inositol 1,4,5-trisphosphate 5-phosphatase; 5PTASE; 43 kDa inositol polyphosphate 5 phophatase; CTCL tumor antigen HD CL 02; inositol polyphosphate 5 phophatase; 40kDa; InsP3 5 phosphatase; type I inositol 1; 4; 5 trisphosphate 5 phosphatase; InsP3 5-phosphatase; CTCL tumor antigen HD-CL-02; 43 kDa inositol polyphosphate 5-phophatase; inositol trisphosphate-5-phosphatase, 40kD; type I inositol-1,4,5-trisphosphate 5-phophatase; type I inositol-1,4,5-trisphosphate 5-phosphatase; MGC116947; MGC116949; DKFZp434A1721
• Gene ID: 3632
• mRNA Refseq: NM_005539
• Protein Refseq: NP_005530
• MIM: 600106
• UniProt ID: Q14642

Reviews

11/27/2021

The product's rapid action in triggering cellular responses significantly expedited our experiments.

08/30/2020

The user-friendly design of the product made it accessible to researchers with varying levels of expertise.

01/11/2019

The availability of technical experts for consultations greatly aided in optimizing our experiments.

Q&As

What is the gene summary of INPP5A according to Entrez?

According to Entrez, the protein encoded by INPP5A is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.

In what cellular process does INPP5A play a crucial role?

INPP5A plays a crucial role in the survival of cerebellar Purkinje cells.

What type of inositol phosphate does INPP5A hydrolyze?

INPP5A specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

What is the main function of INPP5A?

INPP5A is a phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

Can you provide information on the molecular structure of INPP5A?

INPP5A has a specific catalytic domain that is responsible for its phosphatase activity. The structural details of INPP5A are important for understanding its function in inositol phosphate metabolism.

What is the molecular function of INPP5A?

INPP5A functions as a hydrolase.

What is the role of INPP5A in cellular signaling?

INPP5A regulates cellular signaling by controlling the levels of inositol phosphates, which are important secondary messengers in many cellular pathways.