Recombinant Human INPP5A Protein (1-409 aa), His-SUMO-tagged

• Cat.No.: INPP5A-1012H
• Product Overview: Recombinant Human INPP5A Protein (1-409 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.

Specification

• Description: Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 63.5 kDa
• Protein length: 1-409 aa
• AA Sequence: MAGKAAAPGTAVLLVTANVGSLFDD PENLQKNWLREFYQVVHTHKPHFMA LHCQEFGGKNYEASMSHVDKFVKEL LSSDAMKEYNRARVYLDENYKSQEH FTALGSFYFLHESLKNIYQFDFKAK KYRKVAGKEIYSDTLESTPMLEKEK FPQDYFPECKWSRKGFIRTRWCIAD CAFDLVNIHLFHDASNLVAWETSPS VYSGIRHKALGYVLDRIIDQRFEKV SYFVFGDFNFRLDSKSVVETLCTKA TMQTVRAADTNEVVKLIFRESDNDR KVMLQLEKKLFDYFNQEVFRDNNGT ALLEFDKELSVFKDRLYELDISFPP SYPYSEDARQGEQYMNTRCPAWCDR ILMSPSAKELVLRSESEEKVVTYDH IGPNVCMGDHKPVFLAFRIMPGAGK PHAHVHKCC
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: INPP5A inositol polyphosphate-5-phosphatase, 40kDa [ Homo sapiens ]
• Official Symbol: INPP5A
• Synonyms: INPP5A; 5PTASE; MGC116947; MGC116949; DKFZp434A1721
• Gene ID: 3632
• mRNA Refseq: NM_005539
• Protein Refseq: NP_005530
• MIM: 600106
• UniProt ID: Q14642

Reviews

11/27/2021

The product's rapid action in triggering cellular responses significantly expedited our experiments.

08/30/2020

The user-friendly design of the product made it accessible to researchers with varying levels of expertise.

01/11/2019

The availability of technical experts for consultations greatly aided in optimizing our experiments.

Q&As

What is the gene summary of INPP5A according to Entrez?

According to Entrez, the protein encoded by INPP5A is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.

In what cellular process does INPP5A play a crucial role?

INPP5A plays a crucial role in the survival of cerebellar Purkinje cells.

What type of inositol phosphate does INPP5A hydrolyze?

INPP5A specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

What is the main function of INPP5A?

INPP5A is a phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.

Can you provide information on the molecular structure of INPP5A?

INPP5A has a specific catalytic domain that is responsible for its phosphatase activity. The structural details of INPP5A are important for understanding its function in inositol phosphate metabolism.

What is the molecular function of INPP5A?

INPP5A functions as a hydrolase.

What is the role of INPP5A in cellular signaling?

INPP5A regulates cellular signaling by controlling the levels of inositol phosphates, which are important secondary messengers in many cellular pathways.