itk
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  • Official Full Name
  • IL2-inducible T-cell kinase
  • Background
  • This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
  • Synonyms
  • ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-
Cat.#:ITK-1049HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ITK Protein (Arg352-Leu620), GST-tagged, Actived By LCK
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Cat.#:ITK-2640HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITK Protein, MYC/DDK-tagged
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Cat.#:ITK-4960HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITK Protein, GST-tagged
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Cat.#:ITK-4961HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ITK Protein
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Cat.#:ITK-5438HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IL2-Inducible T-Cell Kinase, GST-tagged
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Cat.#:ITK-29869THTag:
Source (Host):Species:Human
Product nameRecombinant Human ITK
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Cat.#:ITK-335HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IL2-inducible T-cell Kinase, GST-tagged, Active
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Cat.#:ITK-55HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ITK protein, Flag-tagged, Biotinylated
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Cat.#:ITK-576HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human ITK, GST-tagged
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Cat.#:Itk-1564MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itk protein, His & GST-tagged
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Cat.#:Itk-861MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Itk Protein, GST & His-tagged
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Cat.#:ITK-2318RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ITK Protein, His-tagged
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Cat.#:ITK-8728ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITK
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Cat.#:ITK-1419HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ITK (Active), GST-tagged
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Cat.#:ITK-418MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse ITK cell lysate
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Involved Pathway

ITK involved in several pathways and played different roles in them. We selected most pathways ITK participated on our site, such as Adaptive Immune System, B Cell Receptor Signaling Pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SIGLEC11; TREML2; UBE2E3; DYNC1LI2; PTBP3; PJA2; SPSB2; FAM49BA; MKRN1; KIF5B
B Cell Receptor Signaling Pathway
ARPC1B; LYN; PIK3CA; MAPK4; NRAS; DOK3; CDK2; VAV3; PTPN6; ACTR3
Chemokine signaling pathway
CCL26; Ccl12; GNB1; XCL2; PIK3CB; Ccl21c; SHC4; SRC; CCR3; GNAI2
Class I PI3K signaling events
PLEKHA1; BLK; ITK; ARF1; ADAP1
FCERI mediated Ca+2 mobilization
IGLC2; GRAP2B; IGKV1-5; LCP2A; IGKC; GRAP2A; ITK
Fc epsilon receptor (FCERI) signaling
LAT2; GRAP2B; TAB1; GRAP2A; ITK; RASGRP2; LCP2A
Fc-epsilon receptor I signaling in mast cells
DOK1; PTPN13; LAT2; S1PR1; ITK
Generation of second messenger molecules
HLA-DQB2; GRAP2A; EVL; ITK; GRAP2B

Protein Function

ITK has several biochemical functions, for example, ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITK itself. We selected most functions ITK had, and list some proteins which have the same functions with ITK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX49; ABCD3B; CMPK2; MYO6B; ACSL3; RECQL5; PRKACG; NPR1A; PRKAG2; RUVBL1
Function metal ion binding
Related Protein ZFP410; JMJD1C; ANKMY2A; MMP14A; CADPS; PDZRN3B; ZFP687; ZFPL1; NKD2A; RAG1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein TNK2; YES1; RIPK2; TXK; Fert2; STYK1; JAK2B; TNK1; FYNA; PKDCC
Function protein binding
Related Protein CCDC47; CLPX; HNF4A; RAD51L3; NOP56; STAMBP; SCNN1G; LAMA4; LOC780933; PYDC1
Function NOT receptor binding
Related Protein TEC; TXK; STYK1; LGI1; BTK; BMX; ITK

Interacting Protein

ITK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITK here. Most of them are supplied by our site. Hope this information will be useful for your research of ITK.
LCP2; FASLG; ERBB2; MET; ERBB3; SPRR2A; GAB1; ABI1; IKBKG; HSP90AB1; WAS; G3BP1; EGFR; npm_alk

ITK Related Articles

Sagiv-Barfi, I; Kohrt, HEK; et al. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E966-E972(2015).
Bansal, Y; Silakari, O; et al. 2-Aminobenzimidazole conjugates of NSAIDS: novel compounds with immunomodulatory, anti-inflammatory and antioxidant actions. MEDICINAL CHEMISTRY RESEARCH 24:1170-1179(2015).