Active Recombinant Human ITK, GST-tagged
Cat.No. : | ITK-1419H |
Product Overview : | Recombinant human ITK (352-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor.ITK require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation and shares major substrates with both Lck and Zap-70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 58 nmol/min/mg |
Molecular Mass : | ~53 kDa |
Protein length : | 352 aa-end |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | ITK IL2-inducible T-cell kinase [ Homo sapiens ] |
Official Symbol : | ITK |
Synonyms : | ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; MGC126257; MGC126258; |
Gene ID : | 3702 |
mRNA Refseq : | NM_005546 |
Protein Refseq : | NP_005537 |
MIM : | 186973 |
UniProt ID : | Q08881 |
Chromosome Location : | 5q31-q32 |
Pathway : | Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
ITK-4961H | Active Recombinant Human ITK Protein | +Inquiry |
ITK-1311H | Recombinant Human ITK Protein (M1-L620), Tag Free | +Inquiry |
ITK-1312H | Recombinant Human ITK Protein (M1-L620), GST tagged | +Inquiry |
ITK-4960H | Recombinant Human ITK Protein, GST-tagged | +Inquiry |
ITK-1049H | Recombinant Human ITK Protein (Arg352-Leu620), GST-tagged, Actived By LCK | +Inquiry |
◆ Lysates | ||
ITK-418MCL | Recombinant Mouse ITK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket