mrc1
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  • Official Full Name
  • mannose receptor, C type 1
  • Background
  • The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]
  • Synonyms
  • MRC1; mannose receptor, C type 1; MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1;
Cat.#:MRC1-1462HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MRC1 Protein (655-1213 aa), His-tagged
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Cat.#:MRC1-663HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MRC1 Protein (655-1213 aa), His-SUMO-tagged
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Cat.#:MRC1-5534HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MRC1 Protein, GST-tagged
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Cat.#:MRC1-32HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MRC1 protein, His-tagged
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Cat.#:Mrc1-12MTag:
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Mrc1
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Cat.#:Mrc1-7099MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mrc1 protein, His & T7-tagged
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Cat.#:Mrc1-677RTag:His
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Mrc1, His-tagged
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Cat.#:MRC1-4212HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MRC1 293 Cell Lysate
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Involved Pathway

MRC1 involved in several pathways and played different roles in them. We selected most pathways MRC1 participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
TLR4BB; Cd209g; C3A.1; ITGB1; TUBA1L2; THBS3A; RAB7B; PIKFYVE; TUBB5; TUBA1C
Tuberculosis
LAMP2; HLA-DRB3; IFNB1; CAMK2B; TLR1; IL1B; CAMK2G; IFNG; ATP6V1H; MAPK8

Protein Function

MRC1 has several biochemical functions, for example, mannose binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MRC1 itself. We selected most functions MRC1 had, and list some proteins which have the same functions with MRC1. You can find most of the proteins on our site.
Function
Related Protein
Function mannose binding
Related Protein MBL1; COLEC10; CLEC4M; CLN5; MBL2; CD209A; BSG; CD209B; MANBA; M6PR
Function protein binding
Related Protein PTH2R; KLF13; DNA2; KCNIP2; CUL4B; PSMD4; DIEXF; MEGF6; NADK; BCL2A1A
Function receptor activity
Related Protein PAQR5B; MED16; MED24; PAQR3B; F2RL1; MED14; ITGB1B.2; CRTAM; AMFR; VMN1R40
Function transmembrane signaling receptor activity
Related Protein BAI2; LILRA1; LGR4; TLR18; GHRHRL; CD3D; OR4C12; GP6; TLR2-2; OR12D2
Function virus receptor activity
Related Protein HAVCR1; EFNB2; ITGAV; CD46; CR2; TFRC; CLDN1; F11R; ITGB6; PVRL2

Interacting Protein

MRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRC1.
rpoB; flhA

MRC1 Related Articles

Cheng, L; Xing, H; et al. Lipocalin-2 Promotes M1 Macrophages Polarization in a Mouse Cardiac Ischaemia-Reperfusion Injury Model. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:31-38(2015).
Staines, K; Hunt, LG; et al. Evolution of an Expanded Mannose Receptor Gene Family. PLOS ONE 9:-(2014).