Recombinant Human MRC1 Protein, GST-tagged
Cat.No. : | MRC1-5534H |
Product Overview : | Human MRC1 partial ORF ( NP_002429, 22 a.a. - 130 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 37.73 kDa |
AA Sequence : | TRQFLIYNEDHKRCVDAVSPSAVQT AACNQDAESQKFRWVSESQIMSVAF KLCLGVPSKTDWVAITLYACDSKSE FQKWECKNDTLLGIKGEDLFFNYGN RQEKNIMLY |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MRC1 mannose receptor, C type 1 [ Homo sapiens ] |
Official Symbol : | MRC1 |
Synonyms : | MRC1; mannose receptor, C type 1; mannose receptor, C type 1 like 1 , MRC1L1; macrophage mannose receptor 1; bA541I19.1; CD206; CLEC13D; CLEC13DL; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1; MMR; MRC1L1; MGC181940; |
Gene ID : | 4360 |
mRNA Refseq : | NM_002438 |
Protein Refseq : | NP_002429 |
MIM : | 153618 |
UniProt ID : | P22897 |
Products Types
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Mrc1-10597M | Recombinant Mouse Mrc1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MRC1-1462H | Recombinant Human MRC1 Protein (655-1213 aa), His-tagged | +Inquiry |
Mrc1-3405R | Recombinant Rat Mrc1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MRC1-2454H | Recombinant Human MRC1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MRC1-4212HCL | Recombinant Human MRC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe primary function of MRC1 in the immune system is to recognize and bind mannose on the cell walls of bacteria and fungi, thereby limiting the growth and spread of these pathogens. It is also involved in regulating the activation and phagocytosis of macrophages.
Studies have shown that the expression level of MRC1 is associated with certain infectious diseases, inflammatory diseases, and autoimmune diseases. The high expression of MRC1 may enhance the phagocytosis and killing ability of macrophages and help control infection. However, low expression of MRC1 may affect the activation and function of macrophages, leading to disease progression.
The structure of MRC1 determines its ability to recognize and bind mannose, and where and how it interacts with proteins such as TLR2 and TLR4. The study of its structure can help us understand its function and mechanism of action.
In lung infections, MRC1 may control the progression of lung infections by recognizing and binding to inhaled mannose, triggering an inflammatory response and activation of macrophages. It could be a potential target for the treatment of lung infections.
MRC1 can interact with a variety of other proteins, including TLR2, TLR4, etc. These interactions allow it to recognize and bind to mannose and trigger an inflammatory response and activation of macrophages.
Therapeutic strategies for MRC1 can include regulating its expression level, enhancing its ability to recognize and bind mannose, and promoting macrophage activation and phagocytosis. These methods may have potential applications in the treatment of infectious diseases, inflammatory diseases and autoimmune diseases.
Customer Reviews (3)
Write a reviewWith MRC1, the reproducibility of Western blot was significantly improved.
It can enhance the effectiveness of the body's immune response.
It has high biological activity and stability.
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