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Recombinant Human MRC1 Protein, GST-tagged

Cat.No. : MRC1-5534H
Product Overview : Human MRC1 partial ORF ( NP_002429, 22 a.a. - 130 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 37.73 kDa
AA Sequence : TRQFLIYNEDHKRCVDAVSPSAVQT AACNQDAESQKFRWVSESQIMSVAF KLCLGVPSKTDWVAITLYACDSKSE FQKWECKNDTLLGIKGEDLFFNYGN RQEKNIMLY
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : MRC1 mannose receptor, C type 1 [ Homo sapiens ]
Official Symbol : MRC1
Synonyms : MRC1; mannose receptor, C type 1; mannose receptor, C type 1 like 1 , MRC1L1; macrophage mannose receptor 1; bA541I19.1; CD206; CLEC13D; CLEC13DL; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1; MMR; MRC1L1; MGC181940;
Gene ID : 4360
mRNA Refseq : NM_002438
Protein Refseq : NP_002429
MIM : 153618
UniProt ID : P22897

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the main functions of MRC1 in the immune system? 09/27/2021

The primary function of MRC1 in the immune system is to recognize and bind mannose on the cell walls of bacteria and fungi, thereby limiting the growth and spread of these pathogens. It is also involved in regulating the activation and phagocytosis of macrophages.

Is there a correlation between MRC1 expression level and disease? 07/26/2021

Studies have shown that the expression level of MRC1 is associated with certain infectious diseases, inflammatory diseases, and autoimmune diseases. The high expression of MRC1 may enhance the phagocytosis and killing ability of macrophages and help control infection. However, low expression of MRC1 may affect the activation and function of macrophages, leading to disease progression.

Is there a relationship between the structure and function of MRC1? 07/02/2021

The structure of MRC1 determines its ability to recognize and bind mannose, and where and how it interacts with proteins such as TLR2 and TLR4. The study of its structure can help us understand its function and mechanism of action.

Does MRC1 play a role in lung infections? 09/18/2020

In lung infections, MRC1 may control the progression of lung infections by recognizing and binding to inhaled mannose, triggering an inflammatory response and activation of macrophages. It could be a potential target for the treatment of lung infections.

Does MRC1 interact with other proteins? 09/03/2020

MRC1 can interact with a variety of other proteins, including TLR2, TLR4, etc. These interactions allow it to recognize and bind to mannose and trigger an inflammatory response and activation of macrophages.

What are the treatment strategies for MRC1? 02/15/2020

Therapeutic strategies for MRC1 can include regulating its expression level, enhancing its ability to recognize and bind mannose, and promoting macrophage activation and phagocytosis. These methods may have potential applications in the treatment of infectious diseases, inflammatory diseases and autoimmune diseases.

Customer Reviews (3)

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Reviews
08/30/2023

    With MRC1, the reproducibility of Western blot was significantly improved.

    12/02/2022

      It can enhance the effectiveness of the body's immune response.

      01/12/2021

        It has high biological activity and stability.

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