Recombinant Human MRC1 protein, His-tagged
Cat.No. : | MRC1-30H |
Product Overview : | Recombinant Human MRC1 protein()(Leu19-Ala1389) was fused to His-tagged and expressed in HEK293 |
- Specification
- Gene Information
- Related Products
Description : | Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Molecular Mass : | The protein has a calculated MW of 158.6 kDa. The protein migrates as 150-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Leu19-Ala1389 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | MRC1 |
Official Symbol : | MRC1 |
Synonyms : | MMR, CD206, hMR, MRC1, CLEC13D, CLEC13DL, MRC1L1 |
Gene ID : | 4360 |
mRNA Refseq : | NM_002438.4 |
Protein Refseq : | NP_002429.1 |
MIM : | 153618 |
UniProt ID : | P22897 |
Products Types
◆ Recombinant Protein | ||
Mrc1-10597M | Recombinant Mouse Mrc1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MRC1-3503H | Recombinant Human MRC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MRC1-1462H | Recombinant Human MRC1 Protein (655-1213 aa), His-tagged | +Inquiry |
MRC1-2454H | Recombinant Human MRC1 Protein, His-tagged | +Inquiry |
MRC1-5534H | Recombinant Human MRC1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
MRC1-4212HCL | Recombinant Human MRC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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