thbs1
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  • Official Full Name
  • thrombospondin 1
  • Background
  • The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • THBS1; thrombospondin 1; TSP; THBS; TSP1; TSP-1; THBS-1; thrombospondin-1; thrombospondin-1p180
Cat.#:THBS1-355HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human THBS1 Protein, His-tagged
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Cat.#:THBS1-894HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human THBS1 Protein, MYC/DDK-tagged
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Cat.#:THBS1-185HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Thrombospondin 1
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Cat.#:THBS1-2657HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS1 protein, His-tagged
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Cat.#:THBS1-31513THTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human THBS1 protein, glycosylated
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Cat.#:THBS1-31516THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS1
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Cat.#:Thbs1-2658MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-2659MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-2660MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-659MTag:
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Thbs1
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Cat.#:Thbs1-2661RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2662RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2663RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2664RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:THBS1-4319CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken THBS1
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Cat.#:THBS1-2656CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle THBS1 protein, His & T7-tagged
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Cat.#:THBS1-31514THTag:
Source (Host):Species:Human
Product nameNative Human THBS1
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Cat.#:THBS1-31515THTag:
Source (Host):Species:Human
Product nameNative Human THBS1
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Cat.#:THBS1-4946HTag:N/A
Source (Host):Human PlateletSpecies:Human
Product nameNative Human Thrombospondin protein
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Cat.#:THBS1-5524HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNatve Human Thrombospondin
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Cat.#:THBS1-1101HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human THBS1 293 Cell Lysate
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Cat.#:CDA101Tag:
Source (Host):Species:
Product nameThrombospondin-1 Peptide Antigen
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Involved Pathway

THBS1 involved in several pathways and played different roles in them. We selected most pathways THBS1 participated on our site, such as Rap signaling pathway, p signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
DOCK4; PARD6A; PRKCA; APBB1IP; RAC2; PIK3R2; TLN1; MAPK12; RASGRP3; PDGFRA
p signaling pathway
PIDD1; SESN1; PMAIP1; PPM1DA; CCNB3; BAX; GTSE1; PTEN; CCNG2; CYCSB
Phagosome
ATP6V1D; CD36; TUBA3D; THBS4A; STX12; CLEC4M; TAP1; CANX; HLA-DOA; HBL4
PIK-Akt signaling pathway
EIF4E1B; CCND2; COL6A6; MAPK3; YWHAE; MLST8; IL4; IL2RG; INS2; PRKAA1
TGF-beta signaling pathway
RBL1; NOG2; TGFBR1; ID4; INHBE; AMHR2; BMP7; MAPK1; PPP2CB; TGFBR2
Focal adhesion
RHOAA; PRKCG; RAPGEF1; LAMC3; ERBB2; ITGA2B; FYNA; PDGFRB; Pdgfa&Pdgfb; HGF
ECM-receptor interaction
VTNB; HMMR; SV2C; COL11A1A; HSPG2; COL4A6; ITGB3; LAMB2; COL24A1; CD36
Malaria
ICAM1; CD40; Ccl12; IFNG; KLRK1; ITGB2; TLR2; TLR9; HBA-A2; SDC2
Proteoglycans in cancer
MMP9; ITGB5; SDC4; RDX; CAV1; PTCH1; HOXD10; HPSE2; MAPK3; HIF1A
MicroRNAs in cancer
DICER1; ABCB1A; TNC; RAF1; EP300; SLC45A3; PDCD4; NFKB1; PLCG1; EZH2
Bladder cancer
E2F2; MAPK3; E2F3; FGFR3; CCND1; KRAS; MMP2; HBEGF; EGF; IL-8

Protein Function

THBS1 has several biochemical functions, for example, calcium ion binding, collagen V binding, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS1 itself. We selected most functions THBS1 had, and list some proteins which have the same functions with THBS1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDH2AB10; SLC24A4A; PEF1; OCM; GUCA1B; CDH12; F2; SYT5; PROS1; AIF1L
Function collagen V binding
Related Protein THBS1; ECM2
Function fibrinogen binding
Related Protein THBS1; MFAP2; ITGA2B; FBLN1
Function fibroblast growth factor binding
Related Protein FGFRL1; HSPA9; FGFR2; GLG1; CEP57; FGFR1; SCN5A; PTPRZ1; FGFBP1; GLG1B
Function fibronectin binding
Related Protein IGFBP5; SDC4; IGFBP3; ITGA3; ITGAV; MMP13; LACRT; CCDC80; IGFBP5A; CTSK
Function glycoprotein binding
Related Protein CALR; ACE2; SHB; RGMA; IDE; CSNK1D; CDH1; DNAJA2; APOH; CNTN1
Function heparin binding
Related Protein NRP1A; RSPO1; FGF14; CCL8; LPA; RPL29; FGFR1; FN1; FGF1; BSPH1
Function identical protein binding
Related Protein IGF1R; VPS4B; SKP2; AMELX; KHDRBS1; ZNF3; GRB7; BAIAP2; FXR2; RAF1
Function integrin binding
Related Protein TIMP2; LYN; ITGA5; ILK; ESM1; SFRP2; MFGE8; ADAMTS8; FN1; TGFBI
Function laminin binding
Related Protein NCL; LGALS2A; LRRC15; CTSS; ITGA7; ITGA9; ECM1; PLEKHA2; NID1; LYPD3
Function low-density lipoprotein particle binding
Related Protein THBS1; COLEC12; SCARB1; PCSK9; CRP; CDH13; SORL1; MSR1; SCARF1; LDLR
Function phosphatidylserine binding
Related Protein OSBPL10; GAP43; TRIM72; AXL; RASGRP1; RS1; OSBPL5; THBS1; FCHO2; PLCD1
Function protein binding
Related Protein SLC52A2; ITGAV; CENPK; PIH1D1; TAF2; MBIP; DOHH; RIN1; IRS2; MED15
Function proteoglycan binding
Related Protein FCN2; CTSL1; THBS1; CTSB; COL5A1; NID1; CTSK; SLIT2; CTSS; CECR1
Function transforming growth factor beta binding
Related Protein TGFBR3; ACVR1; THBS1; TGFBR1; LTBP4; LTBP1; VASN; HYAL2; ACVRL1; ENG

Interacting Protein

THBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS1.
PCOLCE; TGFB1; PLEK; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_i_human; collagen_xi_human; collagen_vi_human; FN1; APP; Col11a1; BGN; TGM2