thbs1
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  • Official Full Name
  • thrombospondin 1
  • Background
  • The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • THBS1; thrombospondin 1; TSP; THBS; TSP1; TSP-1; THBS-1; thrombospondin-1; thrombospondin-1p180
Cat.#:THBS1-355HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human THBS1 Protein, His-tagged
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Cat.#:THBS1-894HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human THBS1 Protein, MYC/DDK-tagged
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Cat.#:THBS1-185HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Thrombospondin 1
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Cat.#:THBS1-2657HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS1 protein, His-tagged
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Cat.#:THBS1-31513THTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human THBS1 protein, glycosylated
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Cat.#:THBS1-31516THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS1
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Cat.#:Thbs1-2658MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-2659MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-2660MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs1 protein, His-tagged
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Cat.#:Thbs1-659MTag:
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Thbs1
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Cat.#:Thbs1-2661RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2662RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2663RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:Thbs1-2664RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs1 protein, His-tagged
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Cat.#:THBS1-4319CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken THBS1
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Cat.#:THBS1-2656CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle THBS1 protein, His & T7-tagged
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Cat.#:THBS1-31514THTag:
Source (Host):Species:Human
Product nameNative Human THBS1
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Cat.#:THBS1-31515THTag:
Source (Host):Species:Human
Product nameNative Human THBS1
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Cat.#:THBS1-4946HTag:N/A
Source (Host):Human PlateletSpecies:Human
Product nameNative Human Thrombospondin protein
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Cat.#:THBS1-5524HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNatve Human Thrombospondin
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Cat.#:THBS1-1101HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human THBS1 293 Cell Lysate
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Cat.#:CDA101Tag:
Source (Host):Species:
Product nameThrombospondin-1 Peptide Antigen
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Involved Pathway

THBS1 involved in several pathways and played different roles in them. We selected most pathways THBS1 participated on our site, such as Rap signaling pathway, p signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
MAP2K6; FGFR3; SIPA1L2; TLN1; PDGFRB; PRKCA; CALM2; PARD3; GNAI1; ID1
p signaling pathway
TP73; GADD45BA; ZMAT3; EI24; PTENA; CASP9; CYCS; CCND2A; CYCSB; RCHY1
Phagosome
MHC2A; RILP; CD36; ATP6V0CB; RAC1A; TUBA1A; OLR1; TUBA4L; ATP6V1H; ATP6V0C
PIK-Akt signaling pathway
RPS6KB2; LPAR3; IKBKG; PPP2R5E; PPP2R2B; IFNA1; EPO; PIK3R3; NFKB1; IFNA8
TGF-beta signaling pathway
ACVR1C; TGIF2; TFDP1A; SMAD7B; RPS6KB1B; FST; SMAD3A; RBL1; LEFTY2; GDF5
Focal adhesion
COL1A1B; ROCK2; THBS3; SEPP1; PARVG; ITGA1; MYLPFA; ROCK2B; COL1A1; MYL12B
ECM-receptor interaction
ITGA9; THBS1; ITGA2B; COL6A3; ITGA3; ITGB1; FN1A; THBS4; ITGA7; COL5A2
Malaria
HBB-B2; HBB; HBB-B1; PECAM1; HBA2; IFNG; VCAM1; MYD88; TNF; THBS4
Proteoglycans in cancer
CAV2; ARAF; GRB2; GPC1; RRAS; PTPN11; FZD1; MTOR; PLAU; FASLG
MicroRNAs in cancer
NOTCH2; BRCA1; SHC4; TNC; IRS1; CCND2; RDX; ZFPM2; SERPINB5; MAP2K1
Bladder cancer
BRAF; TRP53; IL-8; MAPK3; MMP1A; CXCL8; MMP2; RAF1; NRAS; RPS6KA5

Protein Function

THBS1 has several biochemical functions, for example, calcium ion binding, collagen V binding, fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS1 itself. We selected most functions THBS1 had, and list some proteins which have the same functions with THBS1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PROC; ASPH; ADAMTS13; C1RA; DUOX2; PCDH2G8; MAN1A1; ANXA4; PCDHB5; PROCA
Function collagen V binding
Related Protein ECM2; THBS1
Function fibrinogen binding
Related Protein THBS1; ITGA2B; MFAP2; FBLN1
Function fibroblast growth factor binding
Related Protein KLB; HSPA9; RPS2; FIBP; FGFR3; GLG1; FGFR1A; FGFR1; FIBPA; FGFBP3
Function fibronectin binding
Related Protein LACRT; IGFBP5A; HSD17B12; MFAP2; FBLN1; ITGB3; CTSK; THBS1; VEGFA; IGFBP5B
Function glycoprotein binding
Related Protein BBC3; HSPA5; FOXRED2; CALR; BMPR1A; AZGP1; FBXO27; CDH1; ITGB2; BMPR1B
Function heparin binding
Related Protein CCDC80; APOH; FGF12; TENM1; NRP2; BMP4; WISP3; FGF7; FGFR2; COL5A1
Function identical protein binding
Related Protein WRNIP1; DPP4; PPPDE2; CLDN1; BLOC1S6; TRAF6; TRIM39; NUDT16; ETNPPL; CLDND
Function integrin binding
Related Protein CYR61; TSPAN4; ITGB1BP2; CYR61L1; LAMB1; COL16A1; AMICA1; S1PR3; VTN; P4HB
Function laminin binding
Related Protein PLEKHA2; ACHE; ITGA3; THBS1; LGALS1; LGALS3; ECM1; ADAM9; LRRC15; ITGA7
Function low-density lipoprotein particle binding
Related Protein LIPC; CRP; COLEC12; CDH13; MSR1; SCARF1; SCARB1; THBS1; LDLR; SORL1
Function phosphatidylserine binding
Related Protein RASGRP1; SYTL2; SDPR; AP1S2; ANXA13; OSBPL5; SYT4; SCARB1; CPNE1; THBS1
Function protein binding
Related Protein KCNRG; INTS10; NTN1; CISH; CTAG1A; ARFIP2; IFIT1; UPRT; LRRFIP1; PLAA
Function proteoglycan binding
Related Protein CECR1; CTSK; CTSS; UBE4A; CTSB; CECR1A; FCN2; CTSL1; THBS1; COL5A1
Function transforming growth factor beta binding
Related Protein HYAL2; CD109; ITGAV; TGFBR1; ENG; TGFBR2; TGFB3; ACVR1; VASN; THBS1

Interacting Protein

THBS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS1.
PCOLCE; TGFB1; PLEK; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_i_human; collagen_xi_human; collagen_vi_human; FN1; APP; Col11a1; BGN; TGM2