Recombinant Human THBS1 Protein, His-tagged
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|Product Overview :||Recombinant Human THBS1 fused with His tag at the C-terminus was produced in HEK293.|
|Description :||Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive, and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells(EC), and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).|
|Form :||Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.|
|Protein length :||Asn19-Pro1170|
|AA sequence :||NRIPESGGDN SVFDIFELTG AARKGSGRRL VKGPDPSSPA FRIEDANLIP PVPDDKFQDL VDAVRAEKGF LLLASLRQMK KTRGTLLALE RKDHSGQVFS VVSNGKAGTL DLSLTVQGKQ HVVSVEEALL ATGQWKSITL FVQEDRAQLY IDCEKMENAE LDVPIQSVFT RDLASIARLR IAKGGVNDNF QGVLQNVRFV FGTTPEDILR NKGCSSSTSV LLTLDNNVVN GSSPAIRTNY IGHKTKDLQA ICGISCDELS SMVLELRGLR TIVTTLQDSI RKVTEENKEL ANELRRPPLC YHNGVQYRNN EEWTVDSCTE CHCQNSVTIC KKVSCPIMPC SNATVPDGEC CPRCWPSDSA DDGWSPWSEW TSCSTSCGNG IQQRGRSCDS LNNRCEGSSV QTRTCHIQEC DKRFKQDGGW SHWSPWSSCS VTCGDGVITR IRLCNSPSPQ MNGKPCEGEA RETKACKKDA CPINGGWGPW SPWDICSVTC GGGVQKRSRL CNNPTPQFGG KDCVGDVTEN QICNKQDCPI DGCLSNPCFA GVKCTSYPDG SWKCGACPPG YSGNGIQCTD VDECKEVPDA CFNHNGEHRC ENTDPGYNCL PCPPRFTGSQ PFGQGVEHAT ANKQVCKPRN PCTDGTHDCN KNAKCNYLGH YSDPMYRCEC KPGYAGNGII CGEDTDLDGW PNENLVCVAN ATYHCKKDNC PNLPNSGQED YDKDGIGDAC DDDDDNDKIP DDRDNCPFHY NPAQYDYDRD DVGDRCDNCP YNHNPDQADT DNNGEGDACA ADIDGDGILN ERDNCQYVYN VDQRDTDMDG VGDQCDNCPL EHNPDQLDSD SDRIGDTCDN NQDIDEDGHQ NNLDNCPYVP NANQADHDKD GKGDACDHDD DNDGIPDDKD NCRLVPNPDQ KDSDGDGRGD ACKDDFDHDS VPDIDDICPE NVDISETDFR RFQMIPLDPK GTSQNDPNWV VRHQGKELVQ TVNCDPGLAV GYDEFNAVDF SGTFFINTER DDDYAGFVFG YQSSSRFYVV MWKQVTQSYW DTNPTRAQGY SGLSVKVVNS TTGPGEHLRN ALWHTGNTPG QVRTLWHDPR HIGWKDFTAY RWRLSHRPKT GFIRVVMYEG KKIMADSGPI YDKTYAGGRL GLFVFSQEMV FFSDLKYECR DPGGGGSHHH HHHHHHH|
|Endotoxin :||Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.|
|Purity :||Greater than 95% as determined by reducing SDS-PAGE.|
|Storage :||Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
|Reconstitution :||Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Shipping :||The product is shipped at ambient temperature.|
|Gene Name :||THBS1 thrombospondin 1 [ Homo sapiens ]|
|Official Symbol :||THBS1|
|Synonyms :||THBS1; thrombospondin 1; thrombospondin-1; THBS; THBS 1; thrombospondin 1p180; TSP; TSP 1; TSP1; thrombospondin-1p180; TSP-1; THBS-1;|
|Gene ID :||7057|
|mRNA Refseq :||NM_003246|
|Protein Refseq :||NP_003237|
|UniProt ID :||P07996|
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