Recombinant Human THBS1 protein, His-tagged

• Cat.No.: THBS1-3321H
• Product Overview: Recombinant Human THBS1 protein(25-250 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 25-250 aa
• AA Sequence: GGDNSVFDIFELTGAARKGSGRRLV KGPDPSSPAFRIEDANLIPPVPDDK FQDLVDAVRAEKGFLLLASLRQMKK TRGTLLALERKDHSGQVFSVVSNGK AGTLDLSLTVQGKQHVVSVEEALLA TGQWKSITLFVQEDRAQLYIDCEKM ENAELDVPIQSVFTRDLASIARLRI AKGGVNDNFQGVLQNVRFVFGTTPE DILRNKGCSSSTSVLLTLDNNVVNG S
• Purity: 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: THBS1 thrombospondin 1 [ Homo sapiens ]
• Official Symbol: THBS1
• Synonyms: THBS1; thrombospondin 1; thrombospondin-1; THBS; THBS 1; thrombospondin 1p180; TSP; TSP 1; TSP1; thrombospondin-1p180; TSP-1; THBS-1
• Gene ID: 7057
• mRNA Refseq: NM_003246
• Protein Refseq: NP_003237
• MIM: 188060
• UniProt ID: P07996

Reviews

05/14/2022

Quality exceeded my expectations.

09/08/2021

Satisfied customer, will return.

11/21/2020

Very pure, excellent results.

Q&As

In which tissues or cell types is THBS1 predominantly expressed?

THBS1 is widely expressed but is upregulated in response to injury or in certain disease states.

How is THBS1 implicated in cancer progression?

It can either promote or inhibit cancer progression, depending on the context.

How does THBS1 contribute to cell-matrix interactions?

It binds to extracellular matrix components, influencing cell attachment and signaling.

What role does THBS1 play in angiogenesis?

THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.

What therapeutic strategies are being explored targeting THBS1?

Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.

What is the primary function of THBS1 in cellular processes?

THBS1 modulates cell adhesion, proliferation, and migration.

Are there known genetic variations in THBS1 associated with specific diseases?

Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.