ulk1
Share
  • Official Full Name
  • unc-51-like kinase 1
  • Background
  • Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and cont
  • Synonyms
  • ULK1; unc-51-like kinase 1 (C. elegans); unc 51 (C. elegans) like kinase 1; serine/threonine-protein kinase ULK1; ATG1; ATG1 autophagy related 1 homolog (S. cerevisiae); ATG1A; ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; UNC51
Cat.#:ULK1-557HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ULK1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:ULK1-255HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active
+Inquiry
Cat.#:ULK1-31666THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human ULK1, FLAG-tagged
+Inquiry
Cat.#:ULK1-568HTag:Flag
Source (Host):FreeStyle 293-F cellsSpecies:Human
Product nameRecombinant Human ULK1 protein, FLAG-tagged
+Inquiry
Cat.#:ULK1-17831MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ULK1 Protein
+Inquiry
Cat.#:ULK1-1507HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ULK1 (Active), GST-tagged
+Inquiry
Cat.#:ULK1-505HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ULK1 293 Cell Lysate
+Inquiry

Involved Pathway

ULK1 involved in several pathways and played different roles in them. We selected most pathways ULK1 participated on our site, such as Regulation of autophagy, mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of autophagy
GABARAPL2; IFNA4; INS; ATG12; ULK2; IFNA8; IFNA3; PIK3R4; IFNA10; IFNA1
mTOR signaling pathway
RRN3; RPS6KA1; AKT2L; PIK3R3B; PRKCA; STRADA; EIF4E2; INSB; DDIT4; MAPK3
AMPK signaling pathway
PFKFB3; CREB3L4; EEF2; CCNA1; CAMKK2; PDPK1; FASN; CAMKK1; PPP2R2B; PIK3R3

Protein Function

ULK1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK1 itself. We selected most functions ULK1 had, and list some proteins which have the same functions with ULK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RPS6KA2; LIG4; CAMK2G; MELK; MKNK1; MAT2AB; TTLL13; KLHL8; CKMT2B; ATAD1A
Function Rab GTPase binding
Related Protein RAB11FIP4B; RIMS1; ANKRD27; SGSM3; RAB3GAP2; ERC1; STXBP5A; RAB11FIP1; MICALL2; ANKFY1
Function protein binding
Related Protein YWHAZ; DYNC1I2; ZC3H8; TMED2; TSGA10IP; C17orf59; KBTBD6; FH; HOXB6; CD247
Function protein complex binding
Related Protein Cel; PROS1; RPTOR; KRIT1; TULP3; PPP4C; ARRB2; NFYB; KRAS; RBM10
Function protein serine/threonine kinase activity
Related Protein BCR; MAPK12B; RPS6KA4; MAP4K4; SGK3; MAP2K6; PDK3; NUAK2; SLC14A2; ADCK2

Interacting Protein

ULK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK1.
RB1CC1; GABARAP; GABARAPL2; ATG13; MAP1LC3C; MAP1LC3B; GABARAPL1

ULK1 Related Articles

Osaka, M; Ito, D; et al. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1617-1629(2015).
Ribas, VT; Schnepf, B; et al. Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury. BRAIN PATHOLOGY 25:157-170(2015).