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TYR

  • Official Full Name

    tyrosine

  • Overview

    Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is found in numerous disease-affected tissues, such as the cornea in keratoconus. Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetes.
  • Synonyms

    H-3-NITRO-L-TYROSINE; Tyr(3'-NO2); 3-nitro-l-tyrosine; NO2-L.Tyrosine; H-TYR(3-NO2)-OH; H-M-NITRO-TYR-OH; L-Tyrosine, 3-nitro-;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryzias latipes (Japanese rice fish) (Japanese killifish)
  • Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata)
  • Pig
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TYR-222H Recombinant Human Tyrosinase (Oculocutaneous Albinism IA) E.coli N/A
Human TYR-220H Recombinant Human Tyrosinase, GST-tagged Wheat Germ GST
Human TYR-1869HCL Recombinant Human TYR cell lysate N/A
Human TYR-2965H Recombinant Human TYR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TYR-3641H Recombinant Human TYR protein, His-SUMO-tagged E.coli His-SUMO 19-377aa
Human TYR-1016HFL Recombinant Full Length Human TYR Protein, C-Flag-tagged Mammalian cells Flag
Human TYR-238H Recombinant Human TYR Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human TYR-1551H Recombinant Human TYR Protein (19-377 aa), His-tagged Yeast His 19-377 aa
Human TYR-2286H-B Recombinant Human TYR Protein Pre-coupled Magnetic Beads HEK293
Human TYR-2286H Recombinant Human TYR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TYR-17673M Recombinant Mouse TYR Protein Mammalian Cell His
Mouse TYR-9798M Recombinant Mouse TYR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TYR-9798M-B Recombinant Mouse TYR Protein Pre-coupled Magnetic Beads HEK293
Mouse Tyr-6757M Recombinant Mouse Tyr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tyr-9032M Recombinant Mouse Tyr Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 19-533aa
Rat Tyr-518R Recombinant Rat Tyr Protein, His-tagged E.coli N-His Ile233-Leu530
Canis lupus familiaris (Dog) (Canis familiaris) RFL13930CF Recombinant Full Length Dog Tyrosinase(Tyr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-530)
Gallus gallus (Chicken) RFL12883GF Recombinant Full Length Chicken Tyrosinase(Tyr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-529)
Mus musculus (Mouse) RFL12878MF Recombinant Full Length Mouse Tyrosinase(Tyr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-533)
Oryzias latipes (Japanese rice fish) (Japanese killifish) RFL5091OF Recombinant Full Length Oryzias Latipes Tyrosinase(Tyr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-540)
Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) RFL5511PF Recombinant Full Length Pelophylax Nigromaculatus Tyrosinase(Tyr) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-532)
Zebrafish TYR-8643Z Recombinant Zebrafish TYR Mammalian Cell His
Pig TYR-286P Recombinant Pig TYR Protein, His-tagged E.coli His Ala5~Asp245
Chicken TYR-5736C Recombinant Chicken TYR Mammalian Cell His
Kit-0836 Tyrosine Colorimetric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TYR Related Articles

TYR involved in several pathways and played different roles in them. We selected most pathways TYR participated on our site, such as Tyrosine metabolism, Riboflavin metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tyrosine metabolismGSTZ1;AOX4;TH;ALDH1A3;HPDB;ADH2-1;AOX3;DCT;MIF
Riboflavin metabolismBLVRB;RFK;FLAD1;P22;TYR
Metabolic pathwaysALDOA;LDHBB;PANK2;PIP5K1A;ATP6V1E2;STT3B;NME2A;GOT2B;SCLY
MelanogenesisPRKCA;WNT3A;CAMK2G;CAMK2B;MITFB;FZD8A;WNT3;FZD10;WNT5A

TYR has several biochemical functions, for example, copper ion binding, monooxygenase activity, monophenol monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYR itself. We selected most functions TYR had, and list some proteins which have the same functions with TYR. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingHEPHL1A;IL1A;PRNPA;ABHD1;PAM;TYRP1B;MT1;CCS;CCC2
monooxygenase activityCYP2AD3;CH25HL2;CYP51;CYP2X9;CYP2B6;CYP1B1;CYP2C37;CYP4A12A;CYP2X7
monophenol monooxygenase activity
protein bindingMYH7;PSMC5;CARTPT;DCTPP1;MAP2K4;YARS2;MESDC1;ZNF559-ZNF177;NGB
protein heterodimerization activityHIST1H4E;HIST1H2BO;GCA;XBP1;PDGFA;BCL2A;SMAD4;HIST1H3A;PPP2R1A
protein homodimerization activityGSTM1;RAB11FIP4B;IL17F;MFF;HPRT1;PDCD10;DST;PVALB;CLIC6

TYR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYR here. Most of them are supplied by our site. Hope this information will be useful for your research of TYR.

Chen, JL; Walton, KL; et al. Development of Novel Activin-Targeted Therapeutics. MOLECULAR THERAPY 23:434-444(2015).
Sato, A; Yamanaka, H; et al. Highly Stable, Fluorescence-Labeled Heptapeptides Substituted with a D-Amino Acid for the Specific Detection of Oxidized Low-Density Lipoprotein in Plasma. CHEMICAL BIOLOGY & DRUG DESIGN 85:348-355(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Can low levels of TYR protein be increased with medications? 10/05/2022

There are no drugs that directly increase TYR protein levels, but there are drugs that can treat diseases that cause low TYR protein levels.

Does TYR protein play a role in skin aging? 12/16/2021

This protein may play a role in skin aging because it is involved in the production and metabolism of melanin. However, skin aging is also related to other factors, such as genetics, environment, etc.

What is the relationship between TYR protein and whitening products? 06/21/2021

Some whitening products claim to inhibit the TYR protein, thereby reducing the production of melanin. However, the efficacy and safety of these products have yet to be proven.

How to increase the level of TYR protein through diet? 12/29/2020

It is difficult to directly increase the level of TYR protein through diet because TYR protein is mainly genetically determined. However, the presence of copper in the diet can promote the function of the TYR protein.

What does TYR protein have to do with tanning? 12/27/2020

TYR is not directly related to tanning. Tanning is a process by which skin cells produce melanin due to ultraviolet rays.

What is the relationship between TYR protein and skin cancer? 04/20/2020

TYR protein may be involved in the occurrence and progression of skin cancer because it is involved in the production and metabolism of melanin.

Customer Reviews (3)

Write a review
Reviews
04/09/2022

    Repeatability is good, the results of multiple experiments are highly consistent, and the repeatability is particularly good.

    03/31/2021

      High solubility, can be dissolved in various types of reagents, easy to operate.

      01/09/2021

        Not easy to inactivate, tried a variety of experimental conditions, still active.

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