TYR
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Official Full Name
tyrosine
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Overview
Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is found in numerous disease-affected tissues, such as the cornea in keratoconus. Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetes. -
Synonyms
H-3-NITRO-L-TYROSINE; Tyr(3'-NO2); 3-nitro-l-tyrosine; NO2-L.Tyrosine; H-TYR(3-NO2)-OH; H-M-NITRO-TYR-OH; L-Tyrosine, 3-nitro-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Gallus gallus (Chicken)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryzias latipes (Japanese rice fish) (Japanese killifish)
- Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata)
- Pig
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | TYR-222H | Recombinant Human Tyrosinase (Oculocutaneous Albinism IA) | E.coli | N/A | ||
Human | TYR-220H | Recombinant Human Tyrosinase, GST-tagged | Wheat Germ | GST | ||
Human | TYR-1869HCL | Recombinant Human TYR cell lysate | N/A | |||
Human | TYR-2965H | Recombinant Human TYR Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | TYR-3641H | Recombinant Human TYR protein, His-SUMO-tagged | E.coli | His-SUMO | 19-377aa | |
Human | TYR-1016HFL | Recombinant Full Length Human TYR Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | TYR-238H | Recombinant Human TYR Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Human | TYR-1551H | Recombinant Human TYR Protein (19-377 aa), His-tagged | Yeast | His | 19-377 aa | |
Human | TYR-2286H-B | Recombinant Human TYR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | TYR-2286H | Recombinant Human TYR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | TYR-17673M | Recombinant Mouse TYR Protein | Mammalian Cell | His | ||
Mouse | TYR-9798M | Recombinant Mouse TYR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | TYR-9798M-B | Recombinant Mouse TYR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Tyr-6757M | Recombinant Mouse Tyr Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | Tyr-9032M | Recombinant Mouse Tyr Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 19-533aa | |
Rat | Tyr-518R | Recombinant Rat Tyr Protein, His-tagged | E.coli | N-His | Ile233-Leu530 | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL13930CF | Recombinant Full Length Dog Tyrosinase(Tyr) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-530) | |
Gallus gallus (Chicken) | RFL12883GF | Recombinant Full Length Chicken Tyrosinase(Tyr) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-529) | |
Mus musculus (Mouse) | RFL12878MF | Recombinant Full Length Mouse Tyrosinase(Tyr) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (19-533) | |
Oryzias latipes (Japanese rice fish) (Japanese killifish) | RFL5091OF | Recombinant Full Length Oryzias Latipes Tyrosinase(Tyr) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (20-540) | |
Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata) | RFL5511PF | Recombinant Full Length Pelophylax Nigromaculatus Tyrosinase(Tyr) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (20-532) | |
Zebrafish | TYR-8643Z | Recombinant Zebrafish TYR | Mammalian Cell | His | ||
Pig | TYR-286P | Recombinant Pig TYR Protein, His-tagged | E.coli | His | Ala5~Asp245 | |
Chicken | TYR-5736C | Recombinant Chicken TYR | Mammalian Cell | His | ||
Kit-0836 | Tyrosine Colorimetric Assay Kit | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- TYR Related Articles
TYR involved in several pathways and played different roles in them. We selected most pathways TYR participated on our site, such as Tyrosine metabolism, Riboflavin metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Tyrosine metabolism | GSTZ1;AOX4;TH;ALDH1A3;HPDB;ADH2-1;AOX3;DCT;MIF |
Riboflavin metabolism | BLVRB;RFK;FLAD1;P22;TYR |
Metabolic pathways | ALDOA;LDHBB;PANK2;PIP5K1A;ATP6V1E2;STT3B;NME2A;GOT2B;SCLY |
Melanogenesis | PRKCA;WNT3A;CAMK2G;CAMK2B;MITFB;FZD8A;WNT3;FZD10;WNT5A |
TYR has several biochemical functions, for example, copper ion binding, monooxygenase activity, monophenol monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYR itself. We selected most functions TYR had, and list some proteins which have the same functions with TYR. You can find most of the proteins on our site.
Function | Related Protein |
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copper ion binding | HEPHL1A;IL1A;PRNPA;ABHD1;PAM;TYRP1B;MT1;CCS;CCC2 |
monooxygenase activity | CYP2AD3;CH25HL2;CYP51;CYP2X9;CYP2B6;CYP1B1;CYP2C37;CYP4A12A;CYP2X7 |
monophenol monooxygenase activity | |
protein binding | MYH7;PSMC5;CARTPT;DCTPP1;MAP2K4;YARS2;MESDC1;ZNF559-ZNF177;NGB |
protein heterodimerization activity | HIST1H4E;HIST1H2BO;GCA;XBP1;PDGFA;BCL2A;SMAD4;HIST1H3A;PPP2R1A |
protein homodimerization activity | GSTM1;RAB11FIP4B;IL17F;MFF;HPRT1;PDCD10;DST;PVALB;CLIC6 |
TYR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYR here. Most of them are supplied by our site. Hope this information will be useful for your research of TYR.
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are no drugs that directly increase TYR protein levels, but there are drugs that can treat diseases that cause low TYR protein levels.
This protein may play a role in skin aging because it is involved in the production and metabolism of melanin. However, skin aging is also related to other factors, such as genetics, environment, etc.
Some whitening products claim to inhibit the TYR protein, thereby reducing the production of melanin. However, the efficacy and safety of these products have yet to be proven.
It is difficult to directly increase the level of TYR protein through diet because TYR protein is mainly genetically determined. However, the presence of copper in the diet can promote the function of the TYR protein.
TYR is not directly related to tanning. Tanning is a process by which skin cells produce melanin due to ultraviolet rays.
TYR protein may be involved in the occurrence and progression of skin cancer because it is involved in the production and metabolism of melanin.
Customer Reviews (3)
Write a reviewRepeatability is good, the results of multiple experiments are highly consistent, and the repeatability is particularly good.
High solubility, can be dissolved in various types of reagents, easy to operate.
Not easy to inactivate, tried a variety of experimental conditions, still active.
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