rorc
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  • Official Full Name
  • RAR-related orphan receptor C
  • Background
  • The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RORC; RAR-related orphan receptor C; TOR; RORG; RZRG; NR1F3; RZR-GAMMA; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3;
Cat.#:RORC-02HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RORC Protein, GST-tagged
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Cat.#:RORC-114HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human RORC Protein, GST-tagged
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Cat.#:RORC-1357HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RORC Protein, His-SUMO-tagged
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Cat.#:RORC-1084HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RORC protein, His-tagged
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Cat.#:RORC-15HTag:His/Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RORC protein, His/Flag-tagged
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Cat.#:RORC-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RORC protein, MYC/DDK-tagged
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Cat.#:RORC-17HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RORC protein, GST-tagged
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Cat.#:RORC-18HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RORC protein, GST-tagged
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Cat.#:RORC-622HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RORC
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Cat.#:RORC-14381MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RORC Protein
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Cat.#:RORC-2244HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RORC 293 Cell Lysate
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Cat.#:RORC-2245HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RORC 293 Cell Lysate
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Involved Pathway

RORC involved in several pathways and played different roles in them. We selected most pathways RORC participated on our site, such as Circadian rhythm, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORC were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Circadian rhythm
NR1D1; PRKAG2; CUL1; RORC; PRKAG1; PRKAA1; CLOCK; ARNTL; RBX1; BHLHE40
Inflammatory bowel disease (IBD)
TLR4; TLR2; NFATC1; SMAD3; HLA-DRB4; TGFB2; TLR5; H2-AB1; IL2RG; TBX21

Protein Function

RORC has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, oxysterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORC itself. We selected most functions RORC had, and list some proteins which have the same functions with RORC. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF705A; ZNF781; HOXB10A; DHX36; DNAJC2; SSH1; SIX4; MCM9; PBRM1; PIF1
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RORB; RORCA; ESR2; NR2F6A; NR2F5; NR4A2A; RXRA; NR1H4; NR1H3; ESRRA
Function oxysterol binding
Related Protein OSBP; GPR183; RORC; RORA; OSBPL5
Function protein binding
Related Protein FLI1; BTC; PRC1; WTAP; ACE; UNC119; CLN6; ARL2BP; PPP1R11; PEX11A
Function sequence-specific DNA binding
Related Protein NKX3.3; NKX3; MAF; MSXD; ELF2; NR5A1A; LBX1B; PGBD1; WHSC1; DMBX1A
Function steroid hormone receptor activity
Related Protein GPR30; NR1D4B; OR51E2; NR2E3; RARGA; NR2F1; NR2F1B; NR5A2; THRB; NR5A1A
Function transcription factor activity, direct ligand regulated sequence-specific DNA binding
Related Protein RORC; RORA
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN4; EHF; ZBTB25; ATF4; FOXD1; GTF2H2; ZFP746; MNT; L3MBTL4; ASCL1
Function zinc ion binding
Related Protein AGBL3; CNBPA; MAN2B2; L3MBTL1; TRHDE; XRN2; VDRA; CBL; BPTF; CHORDC1

Interacting Protein

RORC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORC here. Most of them are supplied by our site. Hope this information will be useful for your research of RORC.
Clock; Arntl; NCOA1; CREBBP; PPARGC1A; 20-hydroxycholesterol; 25-hydroxycholestero; (22r)-22-hydroxycholesterol; BHLHE40; Per2; EVI2A; PPP2R1A; PPP2R1B; PPP1CC; PPP1CA; PPP1CB; PPP2CA

RORC Related Articles

Lubberts, E; et al. Role of T Lymphocytes in the Development of Rheumatoid Arthritis. Implications for Treatment. CURRENT PHARMACEUTICAL DESIGN 21:142-146(2015).
Balabko, L; Andreev, K; et al. Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror gamma T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. SCIENTIFIC REPORTS 4:-(2014).