Recombinant Human RORC Protein, GST-tagged

Cat.No. : RORC-02H
Product Overview : Recombinant Human RORC fused with GST tag was produced in Insect cells.
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Description : The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
Source : Insect cells
Species : Human
Tag : GST
Form : 50 mM Tris-HCl pH 8.0, 200 mM NaCl
Molecular Mass : ~55kDa as estimated by SDS-PAGE under reducing condition.
AA sequence : PYASLTEIEHLVQSVCKSYRETCQL RLEDLLRQRSNIFSREEVTGYQRKS MWE
MWERCAHHLTEAIQYVVEFAKRLSG FMELCQNDQIVLLKAGAMEVVLVRM CRAYNADN
RTVFFEGKYGGMELFRALGCSELIS SIFDFSHSLSALHFSEDEIALYTAL VLINAHRPGLQ
EKRKVEQLQYNLELAFHHHLCKTHR QSILAKLPPKGKLRSLCSQHVERLQ IFQHLHPIVV
QAAFPPLYKELFS
Purity : > 92% as determined by SDS-PAGE
Storage : Please prepare aliquots and store at -20 ~ -80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.25 mg/ml
Publication :
Discovery of 2‑(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity (2021)
SDS-PAGE:
Gene Name : RORC RAR-related orphan receptor C [ Homo sapiens ]
Official Symbol : RORC
Synonyms : RORC; RAR-related orphan receptor C; nuclear receptor ROR-gamma; NR1F3; RORG; RZRG; TOR; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3; RZR-GAMMA; MGC129539;
Gene ID : 6097
mRNA Refseq : NM_001001523
Protein Refseq : NP_001001523
MIM : 602943
UniProt ID : P51449

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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