Active Recombinant Full Length Human STK11, STRADA and CAB39 Complex Protein, N-His,N-GST,N-GST-tagged
| Cat.No. : | STK11-STRADA-CAB39-92HFL |
| Product Overview : | Complex of N-terminal 6His-tagged, recombinant, full length, human LKB1, N-terminal GSTtagged, recombinant, human, full length STRADα and Nterminal GST-tagged, recombinant, human, full length MO25α, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose followed by Ni2+/NTA agarose. |
- Specification
- Gene Information
- Related Products
| Description : | LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. |
| Source : | Sf21 |
| Species : | Human |
| Tag : | His,GST,GST |
| Protein length : | Full Length |
| Form : | 0.806mg/ml of enzyme in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Bio-activity : | 22U/mg, where one unit of LKB1/STRADα/MO25α activity is defined as 1nmol phosphate incorporated into 300μM (LSNLYHQGKFLQTFCGSPLYRRR) per minute at 30 centigrade with a final ATP concentration of 100μM. |
| Molecular Mass : | LKB1 MW = 52.1 kDa, STRADα MW =76.1 kDa, MO25α MW = 66.8 kDa |
| AA Sequence : | 1 MSYYHHHHHH DYDIPTTENL YFQGAMGSME VVDPQQLGMF TEGELMSVGM DTFIHRIDST 61 EVIYQPRRKR AKLIGKYLMG DLLGEGSYGK VKEVLDSETL CRRAVKILKK KKLRRIPNGE 121 ANVKKEIQLL RRLRHKNVIQ LVDVLYNEEK QKMYMVMEYC VCGMQEMLDS VPEKRFPVCQ 181 AHGYFCQLID GLEYLHSQGI VHKDIKPGNL LLTTGGTLKI SDLGVAEALH PFAADDTCRT 241 SQGSPAFQPP EIANGLDTFS GFKVDIWSAG VTLYNITTGL YPFEGDNIYK LFENIGKGSY 301 AIPGDCGPPL SDLLKGMLEY EPAKRFSIRQ IRQHSWFRKK HPPAEAPVPI PPSPDTKDRW 361 RSMTVVPYLE DLHGADEDED LFDIEDDIIY TQDFTVPGQV PEEEASHNGQ RRGLPKAVCM 421 NGTEAAQLST KSRAEGRAPN PARKACSASS KIRRLSACKQ Q |
| Purity : | Purity 99% by SDS-PAGE and Coomassie blue staining. |
| Applications : | Drug Discovery & Development |
| Storage : | 6 months at -70 centigrade. |
| Handling Advice : | Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade. |
| Use/Stability : | On receipt of material store at -70 centigrade. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap. |
| Gene Name : | STK11 serine/threonine kinase 11 [ Homo sapiens (human) ] and STRADA STE20 related adaptor alpha [ Homo sapiens (human) ] and CAB39 calcium binding protein 39 [ Homo sapiens (human) ] |
| Official Symbol : | STK11 and STRADA and CAB39 |
| Synonyms : | STK11 and STRADA and CAB39; serine/threonine kinase 11 and STE20 related adaptor alpha and calcium binding protein 39; PJS; LKB1; hLKB1 and LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha and MO25; CGI-66 |
| Gene ID : | 6794 and 92335 and 51719 |
| mRNA Refseq : | NM_000455.5 and NM_153335.6 and NM_016289.4 |
| Protein Refseq : | NP_000446.1 and NP_699166.2 and NP_057373.1 |
| MIM : | 602216 and 608626 and 612174 |
| UniProt ID : | Q15831 and Q7RTN6 and Q9Y376 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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