Active Recombinant Human CES1 Protein

Cat.No. : CES1-106H
Product Overview : Recombinant human CES1 protein without tag was expressed in E. coli.
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Description : This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Source : E. coli
Species : Human
Bio-activity : CES Activity Data(Unless otherwise stated, all assays are carried out at 30 centigrade in 50 mM potassium phosphate buffer (pH 7.4)/acetonitrile, 98/2 (v/v))
Substrate: 4-nitrophenyl butyrate
Linear with time up to: 10 min(Determined at 90 μM substrate, using a protein concentration of 15 μg/ml)
Linear with protein up to: 50 μg/ml(Determined at 90 μM substrate)
Vmax: 511 nmol/min/mg protein
Km: 152 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : Protein Concentration: 10 mg/ml
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Publication :
Gene Name : CES1 carboxylesterase 1 [ Homo sapiens (human) ]
Official Symbol : CES1
Synonyms : CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; acyl coenzyme A:cholesterol acyltransferase; brain carboxylesterase hBr1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); cholesteryl ester hydrolase; cocaine carboxylesterase; egasyn; human monocyte/macrophage serine esterase 1; methylumbelliferyl-acetate deacetylase 1; monocyte/macrophage serine esterase; retinyl ester hydrolase; serine esterase 1; triacylglycerol hydrolase
Gene ID : 1066
mRNA Refseq : NM_001025194
Protein Refseq : NP_001020365
MIM : 114835
UniProt ID : P23141

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the CES1 enzyme in the human body? 09/01/2022

CES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.

In which tissues or organs is CES1 most abundantly expressed? 07/10/2021

CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.

How does CES1 contribute to drug metabolism? 09/14/2020

It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.

What is the significance of CES1 in the metabolism of prodrugs? 05/04/2020

CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.

How can genetic variations in the CES1 gene affect drug response? 03/08/2020

Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.

Are there known inhibitors or activators of CES1, and how might they influence its activity? 04/06/2019

Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.

What role does CES1 play in lipid metabolism? 02/13/2018

It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.

Customer Reviews (3)

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Reviews
03/29/2022

    Reliable for lab work.

    09/16/2021

      Great value for quality.

      09/03/2020

        Good quality, great service.

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