Recombinant Human GNL3L Protein (1-582 aa), His-SUMO-tagged

Cat.No. : GNL3L-1121H
Product Overview : Recombinant Human GNL3L Protein (1-582 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length.
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Description : Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 81.6 kDa
Protein length : 1-582 aa
AA Sequence : MMKLRHKNKKPGEGSKGHKKISWPY PQPAKQNGKKATSKVPSAPHFVHPN DHANREAELKKKWVEEMREKQQAAR EQERQKRRTIESYCQDVLRRQEEFE HKEEVLQELNMFPQLDDEATRKAYY KEFRKVVEYSDVILEVLDARDPLGC RCFQMEEAVLRAQGNKKLVLVLNKI DLVPKEVVEKWLDYLRNELPTVAFK ASTQHQVKNLNRCSVPVDQASESLL KSKACFGAENLMRVLGNYCRLGEVR THIRVGVVGLPNVGKSSLINSLKRS RACSVGAVPGITKFMQEVYLDKFIR LLDAPGIVPGPNSEVGTILRNCVHV QKLADPVTPVETILQRCNLEEISNY YGVSGFQTTEHFLTAVAHRLGKKKK GGLYSQEQAAKAVLADWVSGKISFY IPPPATHTLPTHLSAEIVKEMTEVF DIEDTEQANEDTMECLATGESDELL GDTDPLEMEIKLLHSPMTKIADAIE NKTTVYKIGDLTGYCTNPNRHQMGW AKRNVDHRPKSNSMVDVCSVDRRSV LQRIMETDPLQQGQALASALKNKKK MQKRADKIASKLSDSMMSALDLSGN ADDGVGD
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
SDS-PAGE: (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Gene Name : GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like [ Homo sapiens ]
Official Symbol : GNL3L
Synonyms : GNL3L; FLJ10613; novel GTPase; RP11-353K22.1;
Gene ID : 54552
mRNA Refseq : NM_001184819
Protein Refseq : NP_001171748
UniProt ID : Q9NVN8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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