Recombinant Human EEF2K, GST-tagged, Active

• Cat.No.: EEF2K-296H
• Product Overview: Recombinant full-length human EEF2K was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=125 kDa.

Specification

• Cat. No.: EEF2K-296H
• Description: EEF2K is a highly conserved calmodulin-dependent protein kinase that links activation of cell surface receptors to cell division. EEF2K is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2), an abundant cytoplasmic protein that catalyzes the movement of the ribosome along mRNA during translation in eukaryotic cells, and inhibits the EEF2 function. EEF2K is highly expressed in heart and skeletal muscle, suggesting that EEF2 phosphorylation may be particularly important in muscle. EEF2K is highly expressed in patients with systemic lupus erythematosus as well as in many cancers.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: EEF2K eukaryotic elongation factor-2 kinase [ Homo sapiens ]
• Synonyms: EEF2K; eukaryotic elongation factor-2 kinase; eEF-2K; HSU93850; MGC45041; elongation factor-2 kinase; eEF-2 kinase; calmodulin-dependent protein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; EC 2.7.11.20
• Gene ID: 29904
• mRNA Refseq: NM_013302
• Protein Refseq: NP_037434
• MIM: 606968
• UniProt ID: O00418
• Chromosome Location: 16p12
• Pathway: Signaling by Insulin receptor
• Function: ATP binding; calcium ion binding; elongation factor-2 kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity; translation factor activity, nucleic acid binding